BRD-K02708799_GSK-1059615_SKBR3_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-K02708799_GSK-1059615_SKBR3_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACKR3 atypical chemokine receptor 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
APOD apolipoprotein D
BASP1 brain abundant, membrane attached signal protein 1
BCAS1 breast carcinoma amplified sequence 1
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COMT catechol-O-methyltransferase
CPD carboxypeptidase D
CST1 cystatin SN
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DEPTOR DEP domain containing MTOR-interacting protein
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DOCK9 dedicator of cytokinesis 9
DST dystonin
EAPP E2F-associated phosphoprotein
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
ERBB3 erb-b2 receptor tyrosine kinase 3
ERO1L ERO1-like (S. cerevisiae)
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FXYD3 FXYD domain containing ion transport regulator 3
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GLUL glutamate-ammonia ligase
GOLPH3L golgi phosphoprotein 3-like
GRB7 growth factor receptor-bound protein 7
IGF1 insulin-like growth factor 1 (somatomedin C)
INHBB inhibin, beta B
IRS2 insulin receptor substrate 2
KAT6B K(lysine) acetyltransferase 6B
KLHDC2 kelch domain containing 2
LAMB1 laminin, beta 1
LEPR leptin receptor
LITAF lipopolysaccharide-induced TNF factor
MARCKS myristoylated alanine-rich protein kinase C substrate
MEIS1 Meis homeobox 1
MLPH melanophilin
MTUS1 microtubule associated tumor suppressor 1
NDRG1 N-myc downstream regulated 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
OBSL1 obscurin-like 1
PCBP2 poly(rC) binding protein 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAP1GAP RAP1 GTPase activating protein
S100P S100 calcium binding protein P
SH3YL1 SH3 and SYLF domain containing 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SRGN serglycin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TM4SF1 transmembrane 4 L six family member 1
TRA2A transformer 2 alpha homolog (Drosophila)
UBXN7 UBX domain protein 7
UGCG UDP-glucose ceramide glucosyltransferase
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)

decreased expression

Symbol Name
AEBP1 AE binding protein 1
AURKA aurora kinase A
CASP10 caspase 10, apoptosis-related cysteine peptidase
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COL6A2 collagen, type VI, alpha 2
CORO1A coronin, actin binding protein, 1A
CXCL14 chemokine (C-X-C motif) ligand 14
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
EPHB6 EPH receptor B6
FAS Fas cell surface death receptor
FZD7 frizzled class receptor 7
GAL galanin/GMAP prepropeptide
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
HACD3 3-hydroxyacyl-CoA dehydratase 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
LMO3 LIM domain only 3 (rhombotin-like 2)
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAM1 neural cell adhesion molecule 1
NPTX2 neuronal pentraxin II
OLFM1 olfactomedin 1
PLK1 polo-like kinase 1
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
POSTN periostin, osteoblast specific factor
PRKCB protein kinase C, beta
PRSS2 protease, serine, 2 (trypsin 2)
RRM2 ribonucleotide reductase M2
SATB1 SATB homeobox 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPP1 secreted phosphoprotein 1
TDO2 tryptophan 2,3-dioxygenase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPM1 tropomyosin 1 (alpha)
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb