BRD-K02708799_GSK-1059615_PC3_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

366 genes differentially expressed following the BRD-K02708799_GSK-1059615_PC3_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTN1 actinin, alpha 1
ADD3 adducin 3 (gamma)
AGR2 anterior gradient 2
AHR aryl hydrocarbon receptor
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
APOD apolipoprotein D
APOL1 apolipoprotein L, 1
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ATP9A ATPase, class II, type 9A
BANK1 B-cell scaffold protein with ankyrin repeats 1
BHLHE41 basic helix-loop-helix family, member e41
BMP2 bone morphogenetic protein 2
BPHL biphenyl hydrolase-like (serine hydrolase)
BTBD3 BTB (POZ) domain containing 3
C10ORF10 chromosome 10 open reading frame 10
C1RL complement component 1, r subcomponent-like
CCDC92 coiled-coil domain containing 92
CD302 CD302 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK14 cyclin-dependent kinase 14
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFD complement factor D (adipsin)
CFI complement factor I
CHL1 cell adhesion molecule L1-like
CLDN7 claudin 7
COBL cordon-bleu WH2 repeat protein
COL1A1 collagen, type I, alpha 1
COL4A5 collagen, type IV, alpha 5
COLEC12 collectin sub-family member 12
COMP cartilage oligomeric matrix protein
CPB1 carboxypeptidase B1 (tissue)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST3 cystatin C
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTGF connective tissue growth factor
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DACH1 dachshund family transcription factor 1
DCLK1 doublecortin-like kinase 1
DMD dystrophin
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DPYD dihydropyrimidine dehydrogenase
DSP desmoplakin
DUSP6 dual specificity phosphatase 6
DYNLT3 dynein, light chain, Tctex-type 3
EAPP E2F-associated phosphoprotein
EFNB2 ephrin-B2
ELL2 elongation factor, RNA polymerase II, 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP4 fatty acid binding protein 4, adipocyte
FAM69A family with sequence similarity 69, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FGF13 fibroblast growth factor 13
FLRT2 fibronectin leucine rich transmembrane protein 2
FXYD3 FXYD domain containing ion transport regulator 3
GAA glucosidase, alpha; acid
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALC galactosylceramidase
GAS6 growth arrest-specific 6
GPATCH8 G patch domain containing 8
GPRC5B G protein-coupled receptor, class C, group 5, member B
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
GRWD1 glutamate-rich WD repeat containing 1
GSN gelsolin
GSTK1 glutathione S-transferase kappa 1
H1F0 H1 histone family, member 0
HDAC6 histone deacetylase 6
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HLA-E major histocompatibility complex, class I, E
HMGA1 high mobility group AT-hook 1
HNMT histamine N-methyltransferase
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
INHBA inhibin, beta A
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGAV integrin, alpha V
ITGB5 integrin, beta 5
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
IVNS1ABP influenza virus NS1A binding protein
JAG1 jagged 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCTD12 potassium channel tetramerization domain containing 12
KDM5B lysine (K)-specific demethylase 5B
KLF9 Kruppel-like factor 9
KRT19 keratin 19, type I
KYNU kynureninase
LAMA3 laminin, alpha 3
LAMB1 laminin, beta 1
LDOC1 leucine zipper, down-regulated in cancer 1
LEPR leptin receptor
LEPROT leptin receptor overlapping transcript
LTF lactotransferrin
LXN latexin
LY75 lymphocyte antigen 75
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1C1 mannosidase, alpha, class 1C, member 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MANSC1 MANSC domain containing 1
MAOA monoamine oxidase A
MAP7 microtubule-associated protein 7
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL2 muscleblind-like splicing regulator 2
MLPH melanophilin
MME membrane metallo-endopeptidase
MMP11 matrix metallopeptidase 11
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSLN mesothelin
MT1G metallothionein 1G
MYOF myoferlin
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEFL neurofilament, light polypeptide
NET1 neuroepithelial cell transforming 1
OLFM4 olfactomedin 4
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
OSBPL10 oxysterol binding protein-like 10
OSR2 odd-skipped related transciption factor 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PCOLCE procollagen C-endopeptidase enhancer
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDLIM5 PDZ and LIM domain 5
PENK proenkephalin
PERP PERP, TP53 apoptosis effector
PF4 platelet factor 4
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLAT plasminogen activator, tissue
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PODXL podocalyxin-like
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPAP2B phosphatidic acid phosphatase type 2B
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRSS23 protease, serine, 23
PTPRK protein tyrosine phosphatase, receptor type, K
RAB13 RAB13, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGCC regulator of cell cycle
RNASE4 ribonuclease, RNase A family, 4
RNASET2 ribonuclease T2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100P S100 calcium binding protein P
SCD5 stearoyl-CoA desaturase 5
SEPP1 selenoprotein P, plasma, 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SH3YL1 SH3 and SYLF domain containing 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC35E3 solute carrier family 35, member E3
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SPINK1 serine peptidase inhibitor, Kazal type 1
SSFA2 sperm specific antigen 2
STAB1 stabilin 1
STOM stomatin
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TBX3 T-box 3
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TM9SF3 transmembrane 9 superfamily member 3
TMEM230 transmembrane protein 230
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TPM2 tropomyosin 2 (beta)
TPP1 tripeptidyl peptidase I
TRAK1 trafficking protein, kinesin binding 1
TRIM2 tripartite motif containing 2
TSPAN13 tetraspanin 13
TSPAN31 tetraspanin 31
TSPAN8 tetraspanin 8
TWIST1 twist family bHLH transcription factor 1
TXNIP thioredoxin interacting protein
UBQLN2 ubiquilin 2
VNN1 vanin 1
VPS13B vacuolar protein sorting 13 homolog B (yeast)
VWF von Willebrand factor
WDTC1 WD and tetratricopeptide repeats 1
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ADM adrenomedullin
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AK4 adenylate kinase 4
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDOA aldolase A, fructose-bisphosphate
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AUTS2 autism susceptibility candidate 2
BATF3 basic leucine zipper transcription factor, ATF-like 3
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BIN1 bridging integrator 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C3ORF14 chromosome 3 open reading frame 14
C7 complement component 7
CA12 carbonic anhydrase XII
CALML3 calmodulin-like 3
CCDC86 coiled-coil domain containing 86
CCND2 cyclin D2
CCR7 chemokine (C-C motif) receptor 7
CD24 CD24 molecule
CD320 CD320 molecule
CD69 CD69 molecule
CD9 CD9 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CELF2 CUGBP, Elav-like family member 2
CENPU centromere protein U
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKS2 CDC28 protein kinase regulatory subunit 2
COL1A2 collagen, type I, alpha 2
CORO1A coronin, actin binding protein, 1A
CSE1L CSE1 chromosome segregation 1-like (yeast)
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCR4 chemokine (C-X-C motif) receptor 4
CYCS cytochrome c, somatic
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM162A family with sequence similarity 162, member A
FEN1 flap structure-specific endonuclease 1
FGFR1OP FGFR1 oncogene partner
FGFR3 fibroblast growth factor receptor 3
GAL galanin/GMAP prepropeptide
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNAS GNAS complex locus
GPI glucose-6-phosphate isomerase
GPX3 glutathione peroxidase 3
H2AFX H2A histone family, member X
HBB hemoglobin, beta
HILPDA hypoxia inducible lipid droplet-associated
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA14 heat shock 70kDa protein 14
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFRD2 interferon-related developmental regulator 2
IGFBP5 insulin-like growth factor binding protein 5
IL13RA2 interleukin 13 receptor, alpha 2
IL1R2 interleukin 1 receptor, type II
IL7R interleukin 7 receptor
ITM2A integral membrane protein 2A
KAZN kazrin, periplakin interacting protein
KIAA0226L KIAA0226-like
KIF14 kinesin family member 14
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT15 keratin 15, type I
KRT5 keratin 5, type II
LDHB lactate dehydrogenase B
LMO4 LIM domain only 4
LRRC15 leucine rich repeat containing 15
MALL mal, T-cell differentiation protein-like
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MCM4 minichromosome maintenance complex component 4
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MRPL3 mitochondrial ribosomal protein L3
MYBPC1 myosin binding protein C, slow type
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPTX2 neuronal pentraxin II
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PFKP phosphofructokinase, platelet
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PI3 peptidase inhibitor 3, skin-derived
PLA2G16 phospholipase A2, group XVI
PLN phospholamban
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPIF peptidylprolyl isomerase F
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PROM1 prominin 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTN pleiotrophin
RAD23B RAD23 homolog B (S. cerevisiae)
RAD51C RAD51 paralog C
RBP1 retinol binding protein 1, cellular
RGS1 regulator of G-protein signaling 1
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGD Ras-related GTP binding D
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SFN stratifin
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SOBP sine oculis binding protein homolog (Drosophila)
SPP1 secreted phosphoprotein 1
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TFRC transferrin receptor
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNNC1 troponin C type 1 (slow)
TRIP13 thyroid hormone receptor interactor 13
TTC39A tetratricopeptide repeat domain 39A
TTN titin
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UPP1 uridine phosphorylase 1
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
XAF1 XIAP associated factor 1
ZNF91 zinc finger protein 91