BRD-K02708799_GSK-1059615_MDAMB231_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-K02708799_GSK-1059615_MDAMB231_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACSL1 acyl-CoA synthetase long-chain family member 1
ADIRF adipogenesis regulatory factor
ANPEP alanyl (membrane) aminopeptidase
BASP1 brain abundant, membrane attached signal protein 1
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C14ORF132 chromosome 14 open reading frame 132
CADM1 cell adhesion molecule 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CHIT1 chitinase 1 (chitotriosidase)
CLU clusterin
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DOK5 docking protein 5
DPP4 dipeptidyl-peptidase 4
DSP desmoplakin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
FNBP1 formin binding protein 1
FTH1 ferritin, heavy polypeptide 1
FZD7 frizzled class receptor 7
GATA3 GATA binding protein 3
GBP2 guanylate binding protein 2, interferon-inducible
GPR183 G protein-coupled receptor 183
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
IGFBP5 insulin-like growth factor binding protein 5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1R1 interleukin 1 receptor, type I
KRT14 keratin 14, type I
LAMA3 laminin, alpha 3
LGALS3 lectin, galactoside-binding, soluble, 3
LPL lipoprotein lipase
LPXN leupaxin
MT1M metallothionein 1M
MTSS1 metastasis suppressor 1
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
MYO6 myosin VI
MYOF myoferlin
NEFL neurofilament, light polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUPR1 nuclear protein, transcriptional regulator, 1
OPN3 opsin 3
PBX3 pre-B-cell leukemia homeobox 3
PDE4DIP phosphodiesterase 4D interacting protein
PNRC1 proline-rich nuclear receptor coactivator 1
POSTN periostin, osteoblast specific factor
PRSS21 protease, serine, 21 (testisin)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAB31 RAB31, member RAS oncogene family
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RSRP1 arginine/serine-rich protein 1
S100A10 S100 calcium binding protein A10
SDC4 syndecan 4
SLC38A2 solute carrier family 38, member 2
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
WBP1L WW domain binding protein 1-like
XIST X inactive specific transcript (non-protein coding)
ZIC1 Zic family member 1
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADGRF5 adhesion G protein-coupled receptor F5
ADRB2 adrenoceptor beta 2, surface
AGTR1 angiotensin II receptor, type 1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPH aspartate beta-hydroxylase
ATF5 activating transcription factor 5
BIRC2 baculoviral IAP repeat containing 2
BMP4 bone morphogenetic protein 4
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CCND1 cyclin D1
CD24 CD24 molecule
CDC25A cell division cycle 25A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLC Charcot-Leyden crystal galectin
CSTA cystatin A (stefin A)
CYR61 cysteine-rich, angiogenic inducer, 61
DERA deoxyribose-phosphate aldolase (putative)
DLK1 delta-like 1 homolog (Drosophila)
DPYSL2 dihydropyrimidinase-like 2
DUSP6 dual specificity phosphatase 6
ECM1 extracellular matrix protein 1
EGFR epidermal growth factor receptor
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FHL2 four and a half LIM domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FXYD2 FXYD domain containing ion transport regulator 2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPX1 glutathione peroxidase 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGL immunoglobulin lambda locus
IL13RA2 interleukin 13 receptor, alpha 2
IL1R2 interleukin 1 receptor, type II
LDHB lactate dehydrogenase B
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMO2 LIM domain only 2 (rhombotin-like 1)
LPAR1 lysophosphatidic acid receptor 1
LTF lactotransferrin
MAP7 microtubule-associated protein 7
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAV3 neuron navigator 3
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
NKX3-1 NK3 homeobox 1
NOSIP nitric oxide synthase interacting protein
NPEPL1 aminopeptidase-like 1
NPY1R neuropeptide Y receptor Y1
NT5DC2 5'-nucleotidase domain containing 2
NTS neurotensin
NUP98 nucleoporin 98kDa
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAC8 placenta-specific 8
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
RBM3 RNA binding motif (RNP1, RRM) protein 3
RIN2 Ras and Rab interactor 2
SDPR serum deprivation response
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRR3 small proline-rich protein 3
STEAP1 six transmembrane epithelial antigen of the prostate 1
SYT1 synaptotagmin I
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TIGAR TP53 induced glycolysis regulatory phosphatase
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TPD52L2 tumor protein D52-like 2
TXNDC9 thioredoxin domain containing 9
UBE2S ubiquitin-conjugating enzyme E2S
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon