BRD-K02708799_GSK-1059615_MDAMB231_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

114 genes differentially expressed following the BRD-K02708799_GSK-1059615_MDAMB231_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACTA2 actin, alpha 2, smooth muscle, aorta
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANKRD36B ankyrin repeat domain 36B
ANOS1 anosmin 1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG2 BTG family, member 2
C1RL complement component 1, r subcomponent-like
CCL20 chemokine (C-C motif) ligand 20
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK5RAP3 CDK5 regulatory subunit associated protein 3
COL4A1 collagen, type IV, alpha 1
COL7A1 collagen, type VII, alpha 1
CXCL5 chemokine (C-X-C motif) ligand 5
DKK3 dickkopf WNT signaling pathway inhibitor 3
EGFL6 EGF-like-domain, multiple 6
F5 coagulation factor V (proaccelerin, labile factor)
FABP4 fatty acid binding protein 4, adipocyte
FBN2 fibrillin 2
FCGBP Fc fragment of IgG binding protein
GAA glucosidase, alpha; acid
GADD45B growth arrest and DNA-damage-inducible, beta
GBP2 guanylate binding protein 2, interferon-inducible
GSDMB gasdermin B
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-E major histocompatibility complex, class I, E
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IL1R1 interleukin 1 receptor, type I
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGAV integrin, alpha V
JCHAIN joining chain of multimeric IgA and IgM
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM3A lysine (K)-specific demethylase 3A
KRT19 keratin 19, type I
LBH limb bud and heart development
LDLR low density lipoprotein receptor
LUM lumican
LXN latexin
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MDK midkine (neurite growth-promoting factor 2)
MGP matrix Gla protein
MTSS1 metastasis suppressor 1
MXRA5 matrix-remodelling associated 5
NES nestin
NIPSNAP1 nipsnap homolog 1 (C. elegans)
ORAI3 ORAI calcium release-activated calcium modulator 3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDGFC platelet derived growth factor C
PLA1A phospholipase A1 member A
PPAP2C phosphatidic acid phosphatase type 2C
RAB31 RAB31, member RAS oncogene family
RALGDS ral guanine nucleotide dissociation stimulator
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RTN2 reticulon 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SNAP25 synaptosomal-associated protein, 25kDa
SPARCL1 SPARC-like 1 (hevin)
SPATA20 spermatogenesis associated 20
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TIMP3 TIMP metallopeptidase inhibitor 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TPP1 tripeptidyl peptidase I
TSPAN13 tetraspanin 13

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ADIRF adipogenesis regulatory factor
ADORA2B adenosine A2b receptor
AQP3 aquaporin 3 (Gill blood group)
CCNE2 cyclin E2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC42 cell division cycle 42
CENPU centromere protein U
CGRRF1 cell growth regulator with ring finger domain 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTPS1 CTP synthase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ELANE elastase, neutrophil expressed
ENO1 enolase 1, (alpha)
FOSL1 FOS-like antigen 1
GPI glucose-6-phosphate isomerase
GTPBP8 GTP-binding protein 8 (putative)
HIST1H4C histone cluster 1, H4c
HPRT1 hypoxanthine phosphoribosyltransferase 1
LDHB lactate dehydrogenase B
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MCM10 minichromosome maintenance complex component 10
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
PARP2 poly (ADP-ribose) polymerase 2
PNP purine nucleoside phosphorylase
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
QDPR quinoid dihydropteridine reductase
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
TFRC transferrin receptor
UBE2S ubiquitin-conjugating enzyme E2S
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta