BRD-K02708799_GSK-1059615_MDAMB231_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

227 genes differentially expressed following the BRD-K02708799_GSK-1059615_MDAMB231_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACKR3 atypical chemokine receptor 3
ADA adenosine deaminase
ADAM28 ADAM metallopeptidase domain 28
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALOX5 arachidonate 5-lipoxygenase
ANXA1 annexin A1
ANXA4 annexin A4
APOD apolipoprotein D
ARID5B AT rich interactive domain 5B (MRF1-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
ATP9A ATPase, class II, type 9A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BASP1 brain abundant, membrane attached signal protein 1
BCL3 B-cell CLL/lymphoma 3
C1RL complement component 1, r subcomponent-like
C5AR1 complement component 5a receptor 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL20 chemokine (C-C motif) ligand 20
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CFB complement factor B
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
COL4A1 collagen, type IV, alpha 1
COL5A2 collagen, type V, alpha 2
CP ceruloplasmin (ferroxidase)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSNK1D casein kinase 1, delta
CXCL5 chemokine (C-X-C motif) ligand 5
DDR1 discoidin domain receptor tyrosine kinase 1
DEPTOR DEP domain containing MTOR-interacting protein
DHRS3 dehydrogenase/reductase (SDR family) member 3
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
FAM114A1 family with sequence similarity 114, member A1
FCGBP Fc fragment of IgG binding protein
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FKBP11 FK506 binding protein 11, 19 kDa
FNBP1 formin binding protein 1
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GUSBP3 glucuronidase, beta pseudogene 3
HBD hemoglobin, delta
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HMG20B high mobility group 20B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IRS2 insulin receptor substrate 2
ITGAV integrin, alpha V
JCHAIN joining chain of multimeric IgA and IgM
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA1598
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
LCN2 lipocalin 2
LEPR leptin receptor
LGALS8 lectin, galactoside-binding, soluble, 8
LTBP3 latent transforming growth factor beta binding protein 3
MAGED1 melanoma antigen family D1
MAP7 microtubule-associated protein 7
MEF2C myocyte enhancer factor 2C
MTSS1 metastasis suppressor 1
MXRA5 matrix-remodelling associated 5
MYRF myelin regulatory factor
NMRK1 nicotinamide riboside kinase 1
NOTCH2NL notch 2 N-terminal like
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NTS neurotensin
NUPR1 nuclear protein, transcriptional regulator, 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PILRB paired immunoglobin-like type 2 receptor beta
PNRC1 proline-rich nuclear receptor coactivator 1
PON2 paraoxonase 2
PRSS8 protease, serine, 8
PYCR1 pyrroline-5-carboxylate reductase 1
RAB31 RAB31, member RAS oncogene family
RALGDS ral guanine nucleotide dissociation stimulator
RGCC regulator of cell cycle
RTN2 reticulon 2
S100A12 S100 calcium binding protein A12
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC16A6 solute carrier family 16, member 6
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STK38L serine/threonine kinase 38 like
STXBP2 syntaxin binding protein 2
TCF4 transcription factor 4
THBS2 thrombospondin 2
TMC5 transmembrane channel-like 5
TMEM30B transmembrane protein 30B
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TOB1 transducer of ERBB2, 1
TPD52L1 tumor protein D52-like 1
TPM2 tropomyosin 2 (beta)
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a
VNN1 vanin 1
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
VTCN1 V-set domain containing T cell activation inhibitor 1
WDR13 WD repeat domain 13
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
YPEL5 yippee-like 5 (Drosophila)
ZBED2 zinc finger, BED-type containing 2
ZHX2 zinc fingers and homeoboxes 2
ZNF652 zinc finger protein 652

decreased expression

Symbol Name
ACAT1 acetyl-CoA acetyltransferase 1
ACOT7 acyl-CoA thioesterase 7
ACTN1 actinin, alpha 1
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
AK4 adenylate kinase 4
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
BARD1 BRCA1 associated RING domain 1
BCL2 B-cell CLL/lymphoma 2
BST2 bone marrow stromal cell antigen 2
CBR3 carbonyl reductase 3
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CENPU centromere protein U
CHIC2 cysteine-rich hydrophobic domain 2
COTL1 coactosin-like F-actin binding protein 1
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTPS1 CTP synthase 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP5 dual specificity phosphatase 5
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM162A family with sequence similarity 162, member A
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FUS FUS RNA binding protein
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
GTPBP8 GTP-binding protein 8 (putative)
HAT1 histone acetyltransferase 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HIST1H4C histone cluster 1, H4c
HNRNPL heterogeneous nuclear ribonucleoprotein L
HOXB6 homeobox B6
IL13RA2 interleukin 13 receptor, alpha 2
LMNB1 lamin B1
MAL mal, T-cell differentiation protein
MALL mal, T-cell differentiation protein-like
MATN2 matrilin 2
MCL1 myeloid cell leukemia 1
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
NOLC1 nucleolar and coiled-body phosphoprotein 1
NUP98 nucleoporin 98kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PGAM1 phosphoglycerate mutase 1 (brain)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAC8 placenta-specific 8
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROSC proline synthetase co-transcribed homolog (bacterial)
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTX3 pentraxin 3, long
RAB38 RAB38, member RAS oncogene family
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RANBP1 RAN binding protein 1
RGS4 regulator of G-protein signaling 4
RRAGD Ras-related GTP binding D
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A10 S100 calcium binding protein A10
SCML1 sex comb on midleg-like 1 (Drosophila)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC43A3 solute carrier family 43, member 3
SLIRP SRA stem-loop interacting RNA binding protein
SPRR1A small proline-rich protein 1A
SPRY2 sprouty homolog 2 (Drosophila)
SRM spermidine synthase
STMN1 stathmin 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TSPAN4 tetraspanin 4
TUBB6 tubulin, beta 6 class V
UBE2S ubiquitin-conjugating enzyme E2S
UPP1 uridine phosphorylase 1
WDR1 WD repeat domain 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZWINT ZW10 interacting kinetochore protein