BRD-K02708799_GSK-1059615_MCF7_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

295 genes differentially expressed following the BRD-K02708799_GSK-1059615_MCF7_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
AGR2 anterior gradient 2
AKAP12 A kinase (PRKA) anchor protein 12
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ASPN asporin
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP9A ATPase, class II, type 9A
BCAS3 breast carcinoma amplified sequence 3
BLNK B-cell linker
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPTF bromodomain PHD finger transcription factor
C6ORF48 chromosome 6 open reading frame 48
CAV1 caveolin 1, caveolae protein, 22kDa
CCNG2 cyclin G2
CD200 CD200 molecule
CD47 CD47 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEP68 centrosomal protein 68kDa
CFB complement factor B
CLSTN2 calsyntenin 2
COLEC12 collectin sub-family member 12
CRISP3 cysteine-rich secretory protein 3
CTSK cathepsin K
CUTA cutA divalent cation tolerance homolog (E. coli)
CXCL13 chemokine (C-X-C motif) ligand 13
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCN decorin
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPP4 dipeptidyl-peptidase 4
DSG2 desmoglein 2
DSP desmoplakin
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM134B family with sequence similarity 134, member B
FHL1 four and a half LIM domains 1
FOXN3 forkhead box N3
FOXO4 forkhead box O4
GMPR guanosine monophosphate reductase
GNB5 guanine nucleotide binding protein (G protein), beta 5
GOLGA8A golgin A8 family, member A
GPNMB glycoprotein (transmembrane) nmb
GSTM3 glutathione S-transferase mu 3 (brain)
GSTZ1 glutathione S-transferase zeta 1
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2AC histone cluster 1, H2ac
HNMT histamine N-methyltransferase
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IL1R1 interleukin 1 receptor, type I
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INHBA inhibin, beta A
ITGB5 integrin, beta 5
KLF6 Kruppel-like factor 6
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LTBP3 latent transforming growth factor beta binding protein 3
LUM lumican
LY6E lymphocyte antigen 6 complex, locus E
MBNL2 muscleblind-like splicing regulator 2
MCUR1 mitochondrial calcium uniporter regulator 1
MFAP5 microfibrillar associated protein 5
MPDZ multiple PDZ domain protein
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MTUS1 microtubule associated tumor suppressor 1
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
MXI1 MAX interactor 1, dimerization protein
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NRIP1 nuclear receptor interacting protein 1
ORM1 orosomucoid 1
OSR2 odd-skipped related transciption factor 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PI3 peptidase inhibitor 3, skin-derived
PIP prolactin-induced protein
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLAU plasminogen activator, urokinase
PPIC peptidylprolyl isomerase C (cyclophilin C)
PTGIS prostaglandin I2 (prostacyclin) synthase
PYGL phosphorylase, glycogen, liver
QDPR quinoid dihydropteridine reductase
RBPMS RNA binding protein with multiple splicing
RGS10 regulator of G-protein signaling 10
RSAD2 radical S-adenosyl methionine domain containing 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEPP1 selenoprotein P, plasma, 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP4 secreted frizzled-related protein 4
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMAD3 SMAD family member 3
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMYD3 SET and MYND domain containing 3
SP110 SP110 nuclear body protein
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRGN serglycin
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STC2 stanniocalcin 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
THBS2 thrombospondin 2
TIMP2 TIMP metallopeptidase inhibitor 2
TRIM22 tripartite motif containing 22
USP18 ubiquitin specific peptidase 18
WNT5A wingless-type MMTV integration site family, member 5A
WSB1 WD repeat and SOCS box containing 1
YPEL5 yippee-like 5 (Drosophila)
ZFP36L2 ZFP36 ring finger protein-like 2
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTA2 actin, alpha 2, smooth muscle, aorta
ADIRF adipogenesis regulatory factor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ARL4C ADP-ribosylation factor-like 4C
AURKA aurora kinase A
BAG2 BCL2-associated athanogene 2
C20ORF24 chromosome 20 open reading frame 24
C6ORF62 chromosome 6 open reading frame 62
CA1 carbonic anhydrase I
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CALML4 calmodulin-like 4
CD1E CD1e molecule
CD24 CD24 molecule
CD53 CD53 molecule
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CFAP20 cilia and flagella associated protein 20
CGRRF1 cell growth regulator with ring finger domain 1
COTL1 coactosin-like F-actin binding protein 1
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL5 chemokine (C-X-C motif) ligand 5
DCK deoxycytidine kinase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DOCK4 dedicator of cytokinesis 4
EIF5 eukaryotic translation initiation factor 5
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENOPH1 enolase-phosphatase 1
EPHA3 EPH receptor A3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETV5 ets variant 5
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FOXF1 forkhead box F1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GALE UDP-galactose-4-epimerase
GCLM glutamate-cysteine ligase, modifier subunit
GPM6B glycoprotein M6B
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
HBEGF heparin-binding EGF-like growth factor
HDDC2 HD domain containing 2
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
HSPB8 heat shock 22kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ITGB1BP1 integrin beta 1 binding protein 1
ITM2A integral membrane protein 2A
JAG1 jagged 1
JMJD6 jumonji domain containing 6
KLK6 kallikrein-related peptidase 6
KRT10 keratin 10, type I
KRT18 keratin 18, type I
LGALS1 lectin, galactoside-binding, soluble, 1
LMNB1 lamin B1
LMO4 LIM domain only 4
LRRC17 leucine rich repeat containing 17
LTF lactotransferrin
LY86 lymphocyte antigen 86
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MDK midkine (neurite growth-promoting factor 2)
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP4 microfibrillar-associated protein 4
MPO myeloperoxidase
MSMB microseminoprotein, beta-
MTMR2 myotubularin related protein 2
MYBPC1 myosin binding protein C, slow type
MYH11 myosin, heavy chain 11, smooth muscle
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NES nestin
NQO1 NAD(P)H dehydrogenase, quinone 1
ODC1 ornithine decarboxylase 1
PCDH17 protocadherin 17
PCDH9 protocadherin 9
PDAP1 PDGFA associated protein 1
PDZK1 PDZ domain containing 1
PFN2 profilin 2
PITX1 paired-like homeodomain 1
PKM pyruvate kinase, muscle
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PRDX6 peroxiredoxin 6
PROM1 prominin 1
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTN pleiotrophin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB5C RAB5C, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RHEB Ras homolog enriched in brain
RHOBTB3 Rho-related BTB domain containing 3
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A2 S100 calcium binding protein A2
S100A6 S100 calcium binding protein A6
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SCRG1 stimulator of chondrogenesis 1
SDC2 syndecan 2
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SEPW1 selenoprotein W, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPINK5 serine peptidase inhibitor, Kazal type 5
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SST somatostatin
STAB1 stabilin 1
STK17A serine/threonine kinase 17a
TAGLN transgelin
TAGLN2 transgelin 2
TBX2 T-box 2
TCF21 transcription factor 21
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFA transforming growth factor, alpha
TMEM100 transmembrane protein 100
TMEM47 transmembrane protein 47
TPD52L1 tumor protein D52-like 1
TPM4 tropomyosin 4
TPPP3 tubulin polymerization-promoting protein family member 3
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPYL5 TSPY-like 5
TUBB2A tubulin, beta 2A class IIa
TUBB4B tubulin, beta 4B class IVb
UBE2S ubiquitin-conjugating enzyme E2S
VGLL4 vestigial-like family member 4
VSIG4 V-set and immunoglobulin domain containing 4
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta