BRD-K02708799_GSK-1059615_MCF7_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

204 genes differentially expressed following the BRD-K02708799_GSK-1059615_MCF7_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ADIRF adipogenesis regulatory factor
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ASS1 argininosuccinate synthase 1
ATMIN ATM interactor
ATP9A ATPase, class II, type 9A
BHLHE41 basic helix-loop-helix family, member e41
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCNG2 cyclin G2
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CFI complement factor I
CLEC2B C-type lectin domain family 2, member B
CLU clusterin
COL11A1 collagen, type XI, alpha 1
COL18A1 collagen, type XVIII, alpha 1
COLEC12 collectin sub-family member 12
COPS7A COP9 signalosome subunit 7A
CRISP3 cysteine-rich secretory protein 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CTSB cathepsin B
CTSK cathepsin K
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DST dystonin
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB2 erb-b2 receptor tyrosine kinase 2
F3 coagulation factor III (thromboplastin, tissue factor)
FHL2 four and a half LIM domains 2
FN1 fibronectin 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GAS1 growth arrest-specific 1
GNB5 guanine nucleotide binding protein (G protein), beta 5
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H1C histone cluster 1, H1c
HOXB7 homeobox B7
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IFRD2 interferon-related developmental regulator 2
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
IL13RA1 interleukin 13 receptor, alpha 1
ITGB5 integrin, beta 5
KLF4 Kruppel-like factor 4 (gut)
KRT17 keratin 17, type I
LCN2 lipocalin 2
LXN latexin
LY96 lymphocyte antigen 96
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MDFIC MyoD family inhibitor domain containing
METTL7A methyltransferase like 7A
MMP7 matrix metallopeptidase 7
MMRN1 multimerin 1
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
MT2A metallothionein 2A
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO6 myosin VI
MYOF myoferlin
NDRG1 N-myc downstream regulated 1
NMU neuromedin U
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLFM1 olfactomedin 1
PALLD palladin, cytoskeletal associated protein
PCBP2 poly(rC) binding protein 2
PDZK1IP1 PDZK1 interacting protein 1
PERP PERP, TP53 apoptosis effector
PLAT plasminogen activator, tissue
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPIC peptidylprolyl isomerase C (cyclophilin C)
RAB31 RAB31, member RAS oncogene family
RAI2 retinoic acid induced 2
RAP2A RAP2A, member of RAS oncogene family
RBKS ribokinase
RIN2 Ras and Rab interactor 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPL31 ribosomal protein L31
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SHB Src homology 2 domain containing adaptor protein B
SLC38A1 solute carrier family 38, member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD3 SMAD family member 3
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STON1 stonin 1
TBC1D4 TBC1 domain family, member 4
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNS3 tensin 3
TPBG trophoblast glycoprotein
TRIM2 tripartite motif containing 2
TRIM29 tripartite motif containing 29
TSPAN4 tetraspanin 4
TXNIP thioredoxin interacting protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VCAN versican
VGLL4 vestigial-like family member 4
VIM vimentin
WLS wntless Wnt ligand secretion mediator
ZFPM2 zinc finger protein, FOG family member 2
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACOT7 acyl-CoA thioesterase 7
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AK1 adenylate kinase 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDOA aldolase A, fructose-bisphosphate
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAPN2 calpain 2, (m/II) large subunit
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CPA3 carboxypeptidase A3 (mast cell)
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DHCR7 7-dehydrocholesterol reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
EIF5 eukaryotic translation initiation factor 5
ELF5 E74-like factor 5 (ets domain transcription factor)
ENO1 enolase 1, (alpha)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPCAM epithelial cell adhesion molecule
EREG epiregulin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FTH1 ferritin, heavy polypeptide 1
GCLM glutamate-cysteine ligase, modifier subunit
GPM6B glycoprotein M6B
GPX3 glutathione peroxidase 3
GRWD1 glutamate-rich WD repeat containing 1
GSTA1 glutathione S-transferase alpha 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXB2 homeobox B2
IGHM immunoglobulin heavy constant mu
KAZN kazrin, periplakin interacting protein
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LTF lactotransferrin
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGAM maltase-glucoamylase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NFE2L2 nuclear factor, erythroid 2-like 2
PDZK1 PDZ domain containing 1
PEG10 paternally expressed 10
PGC progastricsin (pepsinogen C)
PIR pirin (iron-binding nuclear protein)
PPAP2A phosphatidic acid phosphatase type 2A
PPAP2B phosphatidic acid phosphatase type 2B
PRKCZ protein kinase C, zeta
PRPF4 pre-mRNA processing factor 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTX3 pentraxin 3, long
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
RGS1 regulator of G-protein signaling 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SRSF3 serine/arginine-rich splicing factor 3
TARS threonyl-tRNA synthetase
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TIMP3 TIMP metallopeptidase inhibitor 3
TNC tenascin C
TPD52 tumor protein D52
TPPP3 tubulin polymerization-promoting protein family member 3
TSPYL5 TSPY-like 5
TYMS thymidylate synthetase
VDAC1 voltage-dependent anion channel 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZSCAN18 zinc finger and SCAN domain containing 18