BRD-K02708799_GSK-1059615_MCF10A_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

242 genes differentially expressed following the BRD-K02708799_GSK-1059615_MCF10A_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ADAM10 ADAM metallopeptidase domain 10
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANGPTL2 angiopoietin-like 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD10 ankyrin repeat domain 10
AUTS2 autism susceptibility candidate 2
BLNK B-cell linker
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BST2 bone marrow stromal cell antigen 2
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBR3 carbonyl reductase 3
CCNG2 cyclin G2
CDK14 cyclin-dependent kinase 14
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFH complement factor H
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
COL11A1 collagen, type XI, alpha 1
CPD carboxypeptidase D
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
EGFR epidermal growth factor receptor
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPS8 epidermal growth factor receptor pathway substrate 8
FABP4 fatty acid binding protein 4, adipocyte
FAM13A family with sequence similarity 13, member A
FHL1 four and a half LIM domains 1
FKBP14 FK506 binding protein 14, 22 kDa
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GBP2 guanylate binding protein 2, interferon-inducible
GLUL glutamate-ammonia ligase
GPX4 glutathione peroxidase 4
GRN granulin
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HP haptoglobin
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI44L interferon-induced protein 44-like
IRS2 insulin receptor substrate 2
JUP junction plakoglobin
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0907 KIAA0907
KIF14 kinesin family member 14
KLF9 Kruppel-like factor 9
LOX lysyl oxidase
LPL lipoprotein lipase
MAGED1 melanoma antigen family D1
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MDFIC MyoD family inhibitor domain containing
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MGP matrix Gla protein
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUPR1 nuclear protein, transcriptional regulator, 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PEG10 paternally expressed 10
PLBD1 phospholipase B domain containing 1
PLXNB2 plexin B2
POSTN periostin, osteoblast specific factor
PPARG peroxisome proliferator-activated receptor gamma
PPL periplakin
PTK2 protein tyrosine kinase 2
RABGAP1L RAB GTPase activating protein 1-like
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RSRP1 arginine/serine-rich protein 1
SCPEP1 serine carboxypeptidase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPT10 septin 10
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SESN1 sestrin 1
SLC16A4 solute carrier family 16, member 4
SLC35E2B solute carrier family 35, member E2B
SLC35F2 solute carrier family 35, member F2
SOX4 SRY (sex determining region Y)-box 4
SYNE2 spectrin repeat containing, nuclear envelope 2
TCTA T-cell leukemia translocation altered
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TJP2 tight junction protein 2
TMEM140 transmembrane protein 140
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VAV3 vav 3 guanine nucleotide exchange factor
WDR61 WD repeat domain 61
XIST X inactive specific transcript (non-protein coding)
ZBTB16 zinc finger and BTB domain containing 16
ZIC1 Zic family member 1

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADI1 acireductone dioxygenase 1
ADRB2 adrenoceptor beta 2, surface
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AQP3 aquaporin 3 (Gill blood group)
BAG2 BCL2-associated athanogene 2
BHLHE40 basic helix-loop-helix family, member e40
CALML3 calmodulin-like 3
CCND1 cyclin D1
CCND2 cyclin D2
CDC25A cell division cycle 25A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
COG2 component of oligomeric golgi complex 2
CTSC cathepsin C
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP14 dual specificity phosphatase 14
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFHD2 EF-hand domain family, member D2
EGR1 early growth response 1
EGR3 early growth response 3
EHD1 EH-domain containing 1
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF5A eukaryotic translation initiation factor 5A
EPHA2 EPH receptor A2
EREG epiregulin
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FAM98A family with sequence similarity 98, member A
FGFBP1 fibroblast growth factor binding protein 1
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FST follistatin
GDF15 growth differentiation factor 15
GLIPR1 GLI pathogenesis-related 1
GSTA1 glutathione S-transferase alpha 1
GTPBP4 GTP binding protein 4
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
IER2 immediate early response 2
IER3 immediate early response 3
IL1B interleukin 1, beta
KLF10 Kruppel-like factor 10
KLK10 kallikrein-related peptidase 10
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LBR lamin B receptor
LCN2 lipocalin 2
LPXN leupaxin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MAT2A methionine adenosyltransferase II, alpha
MMP12 matrix metallopeptidase 12
MSMB microseminoprotein, beta-
MSMO1 methylsterol monooxygenase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDN necdin, melanoma antigen (MAGE) family member
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NKX3-1 NK3 homeobox 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
NXT1 nuclear transport factor 2-like export factor 1
OAT ornithine aminotransferase
ODC1 ornithine decarboxylase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PITX1 paired-like homeodomain 1
PLAU plasminogen activator, urokinase
PLK2 polo-like kinase 2
PNO1 partner of NOB1 homolog (S. cerevisiae)
PNP purine nucleoside phosphorylase
PODXL podocalyxin-like
POPDC3 popeye domain containing 3
PPIF peptidylprolyl isomerase F
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRSS3 protease, serine, 3
PTHLH parathyroid hormone-like hormone
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
S100A9 S100 calcium binding protein A9
SCGB2A1 secretoglobin, family 2A, member 1
SDC4 syndecan 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERTAD2 SERTA domain containing 2
SFN stratifin
SH2B3 SH2B adaptor protein 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX9 SRY (sex determining region Y)-box 9
SPRR1A small proline-rich protein 1A
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRSF7 serine/arginine-rich splicing factor 7
TACSTD2 tumor-associated calcium signal transducer 2
TBP TATA box binding protein
TFF3 trefoil factor 3 (intestinal)
TLR4 toll-like receptor 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB2 tribbles pseudokinase 2
TSPYL5 TSPY-like 5
TUBB2A tubulin, beta 2A class IIa
TUBB6 tubulin, beta 6 class V
WFDC2 WAP four-disulfide core domain 2
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing