BRD-K02708799_GSK-1059615_MCF10A_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

317 genes differentially expressed following the BRD-K02708799_GSK-1059615_MCF10A_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABHD4 abhydrolase domain containing 4
ACSL1 acyl-CoA synthetase long-chain family member 1
ADAM10 ADAM metallopeptidase domain 10
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKAP13 A kinase (PRKA) anchor protein 13
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
ANGPTL2 angiopoietin-like 2
ANKRD10 ankyrin repeat domain 10
APLP2 amyloid beta (A4) precursor-like protein 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP9A ATPase, class II, type 9A
BCL6 B-cell CLL/lymphoma 6
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C14ORF132 chromosome 14 open reading frame 132
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBS cystathionine-beta-synthase
CCNG1 cyclin G1
CCNG2 cyclin G2
CD59 CD59 molecule, complement regulatory protein
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFH complement factor H
CLEC7A C-type lectin domain family 7, member A
COBLL1 cordon-bleu WH2 repeat protein-like 1
COLEC12 collectin sub-family member 12
CRYAB crystallin, alpha B
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKFZP586I1420 uncharacterized protein DKFZp586I1420
DOCK9 dedicator of cytokinesis 9
DOK5 docking protein 5
DUSP22 dual specificity phosphatase 22
EML1 echinoderm microtubule associated protein like 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHA3 EPH receptor A3
FABP4 fatty acid binding protein 4, adipocyte
FAM13A family with sequence similarity 13, member A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FBXL12 F-box and leucine-rich repeat protein 12
FKBP5 FK506 binding protein 5
FOLR1 folate receptor 1 (adult)
FOXN3 forkhead box N3
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FZD7 frizzled class receptor 7
GATA3 GATA binding protein 3
GBP2 guanylate binding protein 2, interferon-inducible
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXA5 homeobox A5
HOXC6 homeobox C6
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
IGFBP5 insulin-like growth factor binding protein 5
IL6R interleukin 6 receptor
IRS2 insulin receptor substrate 2
KDM5D lysine (K)-specific demethylase 5D
KIAA0907 KIAA0907
KIF5C kinesin family member 5C
KLF9 Kruppel-like factor 9
KRT7 keratin 7, type II
LEPR leptin receptor
LIMCH1 LIM and calponin homology domains 1
LOX lysyl oxidase
LUM lumican
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA3 melanoma antigen family A3
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MGP matrix Gla protein
MKNK2 MAP kinase interacting serine/threonine kinase 2
MXRA5 matrix-remodelling associated 5
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NPC2 Niemann-Pick disease, type C2
NPY1R neuropeptide Y receptor Y1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM1 olfactomedin 1
OSBPL1A oxysterol binding protein-like 1A
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX3 pre-B-cell leukemia homeobox 3
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDE4DIP phosphodiesterase 4D interacting protein
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PEBP1 phosphatidylethanolamine binding protein 1
PER1 period circadian clock 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PINK1 PTEN induced putative kinase 1
PLS3 plastin 3
PNKP polynucleotide kinase 3'-phosphatase
POSTN periostin, osteoblast specific factor
PRKD1 protein kinase D1
PTK2 protein tyrosine kinase 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
RSRP1 arginine/serine-rich protein 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SCARB2 scavenger receptor class B, member 2
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SESN1 sestrin 1
SIDT2 SID1 transmembrane family, member 2
SKAP2 src kinase associated phosphoprotein 2
SLA Src-like-adaptor
SLC35E2B solute carrier family 35, member E2B
SLC35F2 solute carrier family 35, member F2
SLC38A2 solute carrier family 38, member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPAG4 sperm associated antigen 4
SPINK1 serine peptidase inhibitor, Kazal type 1
STC2 stanniocalcin 2
SULF1 sulfatase 1
SYNE2 spectrin repeat containing, nuclear envelope 2
SYNM synemin, intermediate filament protein
TCF4 transcription factor 4
TCTA T-cell leukemia translocation altered
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS2 thrombospondin 2
TLR4 toll-like receptor 4
TMEM100 transmembrane protein 100
TMSB15A thymosin beta 15a
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
TUG1 taurine up-regulated 1 (non-protein coding)
TUSC3 tumor suppressor candidate 3
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican
ZBTB16 zinc finger and BTB domain containing 16

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
AKAP8 A kinase (PRKA) anchor protein 8
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AQP3 aquaporin 3 (Gill blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BAG3 BCL2-associated athanogene 3
BHLHE40 basic helix-loop-helix family, member e40
C1ORF116 chromosome 1 open reading frame 116
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND1 cyclin D1
CCND2 cyclin D2
CD9 CD9 molecule
CDC25A cell division cycle 25A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CRCT1 cysteine-rich C-terminal 1
CST7 cystatin F (leukocystatin)
CSTA cystatin A (stefin A)
CTSC cathepsin C
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5A cytochrome b5 type A (microsomal)
CYR61 cysteine-rich, angiogenic inducer, 61
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLC1 DLC1 Rho GTPase activating protein
DUSP14 dual specificity phosphatase 14
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
EREG epiregulin
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FERMT1 fermitin family member 1
FGFBP1 fibroblast growth factor binding protein 1
FHL2 four and a half LIM domains 2
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GLIPR1 GLI pathogenesis-related 1
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRIA2 glutamate receptor, ionotropic, AMPA 2
GTPBP4 GTP binding protein 4
HBB hemoglobin, beta
HBD hemoglobin, delta
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HIST1H4C histone cluster 1, H4c
HMGA2 high mobility group AT-hook 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA10 homeobox A10
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL1B interleukin 1, beta
IL1RAP interleukin 1 receptor accessory protein
JAG1 jagged 1
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
KPNA3 karyopherin alpha 3 (importin alpha 4)
KRT13 keratin 13, type I
KRT18 keratin 18, type I
KRT4 keratin 4, type II
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LGALS1 lectin, galactoside-binding, soluble, 1
LIF leukemia inhibitory factor
LIMA1 LIM domain and actin binding 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MAP2K3 mitogen-activated protein kinase kinase 3
MAT2A methionine adenosyltransferase II, alpha
MME membrane metallo-endopeptidase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
NXT1 nuclear transport factor 2-like export factor 1
ODC1 ornithine decarboxylase 1
OLFM4 olfactomedin 4
PCP4 Purkinje cell protein 4
PDE8B phosphodiesterase 8B
PDGFA platelet-derived growth factor alpha polypeptide
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PGAM1 phosphoglycerate mutase 1 (brain)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PLAC8 placenta-specific 8
PLAUR plasminogen activator, urokinase receptor
PNP purine nucleoside phosphorylase
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB38 RAB38, member RAS oncogene family
RGCC regulator of cell cycle
RPIA ribose 5-phosphate isomerase A
RPP38 ribonuclease P/MRP 38kDa subunit
RRBP1 ribosome binding protein 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCGB2A1 secretoglobin, family 2A, member 1
SDC4 syndecan 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX9 SRY (sex determining region Y)-box 9
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRGN serglycin
SRSF7 serine/arginine-rich splicing factor 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
TACSTD2 tumor-associated calcium signal transducer 2
TBP TATA box binding protein
TCL1A T-cell leukemia/lymphoma 1A
TGFA transforming growth factor, alpha
TM4SF1 transmembrane 4 L six family member 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPM4 tropomyosin 4
TUBB2A tubulin, beta 2A class IIa
VAMP8 vesicle-associated membrane protein 8
VWF von Willebrand factor
WNT5A wingless-type MMTV integration site family, member 5A
ZFP36L1 ZFP36 ring finger protein-like 1
ZYX zyxin