BRD-K02708799_GSK-1059615_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

71 genes differentially expressed following the BRD-K02708799_GSK-1059615_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BID BH3 interacting domain death agonist
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFD complement factor D (adipsin)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL12 chemokine (C-X-C motif) ligand 12
DAPK1 death-associated protein kinase 1
FGFR4 fibroblast growth factor receptor 4
FOLR1 folate receptor 1 (adult)
FOXN3 forkhead box N3
GAS1 growth arrest-specific 1
GRN granulin
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HOXC6 homeobox C6
JUN jun proto-oncogene
METTL7A methyltransferase like 7A
MYLK myosin light chain kinase
NOTCH2NL notch 2 N-terminal like
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REEP1 receptor accessory protein 1
RHOBTB3 Rho-related BTB domain containing 3
SIDT2 SID1 transmembrane family, member 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR3 transforming growth factor, beta receptor III
TGM2 transglutaminase 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
CCND1 cyclin D1
CD24 CD24 molecule
CD52 CD52 molecule
CD69 CD69 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CTSZ cathepsin Z
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EREG epiregulin
F3 coagulation factor III (thromboplastin, tissue factor)
FOSL1 FOS-like antigen 1
HBEGF heparin-binding EGF-like growth factor
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
KRT23 keratin 23, type I
KRT6B keratin 6B, type II
LAPTM4B lysosomal protein transmembrane 4 beta
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAP7 microtubule-associated protein 7
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
S100A2 S100 calcium binding protein A2
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SDC4 syndecan 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
VDAC1 voltage-dependent anion channel 1
VEGFA vascular endothelial growth factor A