BRD-K02708799_GSK-1059615_MCF10A_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

405 genes differentially expressed following the BRD-K02708799_GSK-1059615_MCF10A_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
AIM1 absent in melanoma 1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANGPTL2 angiopoietin-like 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD10 ankyrin repeat domain 10
ANXA4 annexin A4
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ASPN asporin
BBS1 Bardet-Biedl syndrome 1
BCL6 B-cell CLL/lymphoma 6
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C14ORF132 chromosome 14 open reading frame 132
C19ORF54 chromosome 19 open reading frame 54
C1ORF54 chromosome 1 open reading frame 54
C1RL complement component 1, r subcomponent-like
CALCOCO1 calcium binding and coiled-coil domain 1
CAV1 caveolin 1, caveolae protein, 22kDa
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD59 CD59 molecule, complement regulatory protein
CD99 CD99 molecule
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CECR1 cat eye syndrome chromosome region, candidate 1
CEP57 centrosomal protein 57kDa
CFB complement factor B
CFD complement factor D (adipsin)
CFLAR CASP8 and FADD-like apoptosis regulator
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL10A1 collagen, type X, alpha 1
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CST1 cystatin SN
CTBP2 C-terminal binding protein 2
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTSK cathepsin K
CXCR4 chemokine (C-X-C motif) receptor 4
CYBB cytochrome b-245, beta polypeptide
DCN decorin
DDAH2 dimethylarginine dimethylaminohydrolase 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EFNA1 ephrin-A1
EMP1 epithelial membrane protein 1
EPHA3 EPH receptor A3
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
FABP4 fatty acid binding protein 4, adipocyte
FADS3 fatty acid desaturase 3
FAXDC2 fatty acid hydroxylase domain containing 2
FBLN1 fibulin 1
FBLN2 fibulin 2
FBN1 fibrillin 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FZD7 frizzled class receptor 7
GAA glucosidase, alpha; acid
GABARAPL1 GABA(A) receptor-associated protein like 1
GAS6 growth arrest-specific 6
GATA3 GATA binding protein 3
GBP2 guanylate binding protein 2, interferon-inducible
GHR growth hormone receptor
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
GRN granulin
GSN gelsolin
GUSBP3 glucuronidase, beta pseudogene 3
GYPC glycophorin C (Gerbich blood group)
HBP1 HMG-box transcription factor 1
HDAC6 histone deacetylase 6
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IL1R1 interleukin 1 receptor, type I
INSR insulin receptor
IPO13 importin 13
IRF9 interferon regulatory factor 9
ITGA10 integrin, alpha 10
ITGAV integrin, alpha V
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JUP junction plakoglobin
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
LAMP2 lysosomal-associated membrane protein 2
LDOC1 leucine zipper, down-regulated in cancer 1
LINC00341 long intergenic non-protein coding RNA 341
LRRC1 leucine rich repeat containing 1
LTBP1 latent transforming growth factor beta binding protein 1
LXN latexin
MAGED2 melanoma antigen family D2
MAOA monoamine oxidase A
MAP1B microtubule-associated protein 1B
MED13L mediator complex subunit 13-like
METTL7A methyltransferase like 7A
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MT1F metallothionein 1F
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
MYO5C myosin VC
NARFL nuclear prelamin A recognition factor-like
NAV2 neuron navigator 2
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFE2L1 nuclear factor, erythroid 2-like 1
NNMT nicotinamide N-methyltransferase
NOX4 NADPH oxidase 4
NRN1 neuritin 1
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PECAM1 platelet/endothelial cell adhesion molecule 1
PEX11A peroxisomal biogenesis factor 11 alpha
PHF20 PHD finger protein 20
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLA2G16 phospholipase A2, group XVI
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN1 perilipin 1
PLIN2 perilipin 2
PLXNB2 plexin B2
PNRC1 proline-rich nuclear receptor coactivator 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPAP2B phosphatidic acid phosphatase type 2B
PPL periplakin
PTK2 protein tyrosine kinase 2
PXDN peroxidasin
PYCARD PYD and CARD domain containing
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGCC regulator of cell cycle
RNASE4 ribonuclease, RNase A family, 4
RNASET2 ribonuclease T2
RRAS related RAS viral (r-ras) oncogene homolog
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SFRP4 secreted frizzled-related protein 4
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC35E2B solute carrier family 35, member E2B
SLC38A2 solute carrier family 38, member 2
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STK38L serine/threonine kinase 38 like
STON1 stonin 1
SULF1 sulfatase 1
SYNE2 spectrin repeat containing, nuclear envelope 2
SYNPO synaptopodin
SYT17 synaptotagmin XVII
TBC1D16 TBC1 domain family, member 16
TCEAL4 transcription elongation factor A (SII)-like 4
TCF4 transcription factor 4
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
TLE2 transducin-like enhancer of split 2
TNS1 tensin 1
TNS3 tensin 3
TPP1 tripeptidyl peptidase I
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
USP6NL USP6 N-terminal like
VAT1 vesicle amine transport 1
VCAN versican
VTCN1 V-set domain containing T cell activation inhibitor 1
WDR45 WD repeat domain 45
WDTC1 WD and tetratricopeptide repeats 1
WISP2 WNT1 inducible signaling pathway protein 2
YPEL5 yippee-like 5 (Drosophila)
ZBTB16 zinc finger and BTB domain containing 16
ZMYND8 zinc finger, MYND-type containing 8
ZNF292 zinc finger protein 292
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADRB2 adrenoceptor beta 2, surface
AK1 adenylate kinase 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
ANXA3 annexin A3
ARF4 ADP-ribosylation factor 4
ARPC5L actin related protein 2/3 complex, subunit 5-like
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
BAG2 BCL2-associated athanogene 2
BLMH bleomycin hydrolase
BOP1 block of proliferation 1
C1QBP complement component 1, q subcomponent binding protein
CACYBP calcyclin binding protein
CCND1 cyclin D1
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CD320 CD320 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK4 cyclin-dependent kinase 4
CKS2 CDC28 protein kinase regulatory subunit 2
COTL1 coactosin-like F-actin binding protein 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTPS1 CTP synthase 1
CTSC cathepsin C
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYCS cytochrome c, somatic
CYR61 cysteine-rich, angiogenic inducer, 61
DBF4 DBF4 zinc finger
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DLC1 DLC1 Rho GTPase activating protein
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
EBP emopamil binding protein (sterol isomerase)
ECI2 enoyl-CoA delta isomerase 2
EGR3 early growth response 3
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELOVL6 ELOVL fatty acid elongase 6
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
EREG epiregulin
EXOSC2 exosome component 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM216A family with sequence similarity 216, member A
FEN1 flap structure-specific endonuclease 1
FGFBP1 fibroblast growth factor binding protein 1
FJX1 four jointed box 1 (Drosophila)
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
FOSL1 FOS-like antigen 1
GALE UDP-galactose-4-epimerase
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GCH1 GTP cyclohydrolase 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
HBEGF heparin-binding EGF-like growth factor
HIST1H4C histone cluster 1, H4c
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD2 interferon-related developmental regulator 2
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
KIAA0020 KIAA0020
KRT6B keratin 6B, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
LCN2 lipocalin 2
LRRC59 leucine rich repeat containing 59
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
MAK16 MAK16 homolog (S. cerevisiae)
MALL mal, T-cell differentiation protein-like
MAP2K3 mitogen-activated protein kinase kinase 3
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MLEC malectin
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP9 matrix metallopeptidase 9
MRPL12 mitochondrial ribosomal protein L12
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAV3 neuron navigator 3
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PGC progastricsin (pepsinogen C)
PGM1 phosphoglucomutase 1
PHB prohibitin
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PLAC8 placenta-specific 8
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PPIF peptidylprolyl isomerase F
PRPF19 pre-mRNA processing factor 19
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PUS7 pseudouridylate synthase 7 (putative)
QDPR quinoid dihydropteridine reductase
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUVBL1 RuvB-like AAA ATPase 1
S100A2 S100 calcium binding protein A2
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCARB1 scavenger receptor class B, member 1
SCGB2A1 secretoglobin, family 2A, member 1
SCML1 sex comb on midleg-like 1 (Drosophila)
SDC1 syndecan 1
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLIRP SRA stem-loop interacting RNA binding protein
SLPI secretory leukocyte peptidase inhibitor
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPF small nuclear ribonucleoprotein polypeptide F
SPATS2L spermatogenesis associated, serine-rich 2-like
SRM spermidine synthase
SRPRB signal recognition particle receptor, B subunit
SRSF2 serine/arginine-rich splicing factor 2
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
SSR1 signal sequence receptor, alpha
TESC tescalcin
TFF3 trefoil factor 3 (intestinal)
TFRC transferrin receptor
TGFA transforming growth factor, alpha
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIPIN TIMELESS interacting protein
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRAPPC3 trafficking protein particle complex 3
TRIP13 thyroid hormone receptor interactor 13
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae)
TSPAN8 tetraspanin 8
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
TXN thioredoxin
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2N ubiquitin-conjugating enzyme E2N
UBE2S ubiquitin-conjugating enzyme E2S
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
UCK2 uridine-cytidine kinase 2
USP1 ubiquitin specific peptidase 1
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
VRK1 vaccinia related kinase 1
WDR12 WD repeat domain 12
WNT5A wingless-type MMTV integration site family, member 5A
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing