BRD-K02708799_GSK-1059615_MCF10A_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

392 genes differentially expressed following the BRD-K02708799_GSK-1059615_MCF10A_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ACKR3 atypical chemokine receptor 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
AKAP13 A kinase (PRKA) anchor protein 13
AKAP9 A kinase (PRKA) anchor protein 9
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ANGPTL2 angiopoietin-like 2
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
ATP9A ATPase, class II, type 9A
BBS1 Bardet-Biedl syndrome 1
BCL6 B-cell CLL/lymphoma 6
BLNK B-cell linker
BLVRB biliverdin reductase B
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPGM 2,3-bisphosphoglycerate mutase
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C14ORF132 chromosome 14 open reading frame 132
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CA12 carbonic anhydrase XII
CALCOCO1 calcium binding and coiled-coil domain 1
CALCOCO2 calcium binding and coiled-coil domain 2
CAMLG calcium modulating ligand
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL5 chemokine (C-C motif) ligand 5
CCNG2 cyclin G2
CD14 CD14 molecule
CD163 CD163 molecule
CD2 CD2 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDK19 cyclin-dependent kinase 19
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CECR1 cat eye syndrome chromosome region, candidate 1
CEP70 centrosomal protein 70kDa
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC2B C-type lectin domain family 2, member B
CLU clusterin
COL18A1 collagen, type XVIII, alpha 1
COL5A2 collagen, type V, alpha 2
COLEC12 collectin sub-family member 12
CRYAB crystallin, alpha B
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYBB cytochrome b-245, beta polypeptide
DCN decorin
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DIAPH2 diaphanous-related formin 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DST dystonin
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EFHC1 EF-hand domain (C-terminal) containing 1
ELMO1 engulfment and cell motility 1
ERBB4 erb-b2 receptor tyrosine kinase 4
EXPH5 exophilin 5
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FAM117A family with sequence similarity 117, member A
FAM134B family with sequence similarity 134, member B
FAM13A family with sequence similarity 13, member A
FBLN2 fibulin 2
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGBP Fc fragment of IgG binding protein
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FLOT1 flotillin 1
FMO3 flavin containing monooxygenase 3
FOLR1 folate receptor 1 (adult)
FOXO4 forkhead box O4
FRY furry homolog (Drosophila)
FTH1 ferritin, heavy polypeptide 1
FYN FYN proto-oncogene, Src family tyrosine kinase
FZD7 frizzled class receptor 7
G0S2 G0/G1 switch 2
GAA glucosidase, alpha; acid
GABARAPL1 GABA(A) receptor-associated protein like 1
GATA3 GATA binding protein 3
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GHR growth hormone receptor
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
GRAMD1C GRAM domain containing 1C
GRB10 growth factor receptor-bound protein 10
GRN granulin
GSDMB gasdermin B
GSN gelsolin
HBB hemoglobin, beta
HBP1 HMG-box transcription factor 1
HDAC6 histone deacetylase 6
HECA headcase homolog (Drosophila)
HILPDA hypoxia inducible lipid droplet-associated
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
IDS iduronate 2-sulfatase
IGFBP5 insulin-like growth factor binding protein 5
IL10RA interleukin 10 receptor, alpha
IL1R1 interleukin 1 receptor, type I
INSIG2 insulin induced gene 2
INSR insulin receptor
IRF9 interferon regulatory factor 9
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KDM3A lysine (K)-specific demethylase 3A
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
KYNU kynureninase
LBH limb bud and heart development
LINC00341 long intergenic non-protein coding RNA 341
LPPR4 lipid phosphate phosphatase-related protein type 4
LRP1 low density lipoprotein receptor-related protein 1
LXN latexin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MAPT microtubule-associated protein tau
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MEF2A myocyte enhancer factor 2A
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MN1 meningioma (disrupted in balanced translocation) 1
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MST1 macrophage stimulating 1
MTMR11 myotubularin related protein 11
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
NAV2 neuron navigator 2
NBPF10 neuroblastoma breakpoint family, member 10
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NINL ninein-like
NMRK1 nicotinamide riboside kinase 1
NNMT nicotinamide N-methyltransferase
NOTCH3 notch 3
NOX4 NADPH oxidase 4
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAX8 paired box 8
PECAM1 platelet/endothelial cell adhesion molecule 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLA2G16 phospholipase A2, group XVI
PLBD1 phospholipase B domain containing 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN1 perilipin 1
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2B phosphatidic acid phosphatase type 2B
PROM1 prominin 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBP1 retinol binding protein 1, cellular
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RNASE4 ribonuclease, RNase A family, 4
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SLC16A6 solute carrier family 16, member 6
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC35E2B solute carrier family 35, member E2B
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SRPX sushi-repeat containing protein, X-linked
ST18 suppression of tumorigenicity 18, zinc finger
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STC1 stanniocalcin 1
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYNE2 spectrin repeat containing, nuclear envelope 2
SYT17 synaptotagmin XVII
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
THEMIS2 thymocyte selection associated family member 2
TLE2 transducin-like enhancer of split 2
TMSB15A thymosin beta 15a
TNS1 tensin 1
TPP1 tripeptidyl peptidase I
TRAC T cell receptor alpha constant
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
VCAM1 vascular cell adhesion molecule 1
VCAN versican
VNN1 vanin 1
VSIG4 V-set and immunoglobulin domain containing 4
VTCN1 V-set domain containing T cell activation inhibitor 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL1 yippee-like 1 (Drosophila)
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACTB actin, beta
ACTN1 actinin, alpha 1
ADORA2B adenosine A2b receptor
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
ANXA3 annexin A3
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
BAG2 BCL2-associated athanogene 2
BLMH bleomycin hydrolase
BOP1 block of proliferation 1
C1QBP complement component 1, q subcomponent binding protein
CACYBP calcyclin binding protein
CCND1 cyclin D1
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CCT7 chaperonin containing TCP1, subunit 7 (eta)
CD320 CD320 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK4 cyclin-dependent kinase 4
CKS2 CDC28 protein kinase regulatory subunit 2
COTL1 coactosin-like F-actin binding protein 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTPS1 CTP synthase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYCS cytochrome c, somatic
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKC1 dyskeratosis congenita 1, dyskerin
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DPH2 DPH2 homolog (S. cerevisiae)
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4E eukaryotic translation initiation factor 4E
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELOVL6 ELOVL fatty acid elongase 6
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ENO1 enolase 1, (alpha)
EPHA2 EPH receptor A2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FERMT1 fermitin family member 1
FGFBP1 fibroblast growth factor binding protein 1
FH fumarate hydratase
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GALE UDP-galactose-4-epimerase
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
GLS glutaminase
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTPBP4 GTP binding protein 4
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
HN1 hematological and neurological expressed 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD2 interferon-related developmental regulator 2
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT18 keratin 18, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KRT81 keratin 81, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
MALL mal, T-cell differentiation protein-like
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MCL1 myeloid cell leukemia 1
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MICALL1 MICAL-like 1
MRPL12 mitochondrial ribosomal protein L12
MRPL42 mitochondrial ribosomal protein L42
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYBPC1 myosin binding protein C, slow type
MYCBP MYC binding protein
NEFH neurofilament, heavy polypeptide
NET1 neuroepithelial cell transforming 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPM3 nucleophosmin/nucleoplasmin 3
NRG1 neuregulin 1
NUP98 nucleoporin 98kDa
OAT ornithine aminotransferase
ODC1 ornithine decarboxylase 1
PA2G4 proliferation-associated 2G4, 38kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PGAM1 phosphoglycerate mutase 1 (brain)
PHB prohibitin
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PLAC8 placenta-specific 8
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPIF peptidylprolyl isomerase F
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRMT1 protein arginine methyltransferase 1
PRPF19 pre-mRNA processing factor 19
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PRSS3 protease, serine, 3
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PUS7 pseudouridylate synthase 7 (putative)
QDPR quinoid dihydropteridine reductase
RANBP1 RAN binding protein 1
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SCARB1 scavenger receptor class B, member 1
SDC1 syndecan 1
SEH1L SEH1-like (S. cerevisiae)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLIRP SRA stem-loop interacting RNA binding protein
SLPI secretory leukocyte peptidase inhibitor
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPF small nuclear ribonucleoprotein polypeptide F
SNRPG small nuclear ribonucleoprotein polypeptide G
SORD sorbitol dehydrogenase
SPP1 secreted phosphoprotein 1
SPRR1A small proline-rich protein 1A
SPRR2B small proline-rich protein 2B
SRGN serglycin
SRM spermidine synthase
SRSF2 serine/arginine-rich splicing factor 2
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
STOML2 stomatin (EPB72)-like 2
TFF3 trefoil factor 3 (intestinal)
TFRC transferrin receptor
TGFBI transforming growth factor, beta-induced, 68kDa
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast)
TMEM5 transmembrane protein 5
TNC tenascin C
TPD52L1 tumor protein D52-like 1
TSPAN8 tetraspanin 8
TUBA4A tubulin, alpha 4a
TUBB6 tubulin, beta 6 class V
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
WDR12 WD repeat domain 12
WDR61 WD repeat domain 61
WDR77 WD repeat domain 77
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta