BRD-K02708799_GSK-1059615_LNCAP_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

125 genes differentially expressed following the BRD-K02708799_GSK-1059615_LNCAP_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANKRD36B ankyrin repeat domain 36B
AREG amphiregulin
AZU1 azurocidin 1
BPTF bromodomain PHD finger transcription factor
CCL2 chemokine (C-C motif) ligand 2
CD44 CD44 molecule (Indian blood group)
DENND2D DENN/MADD domain containing 2D
DUSP6 dual specificity phosphatase 6
ELANE elastase, neutrophil expressed
ETV1 ets variant 1
FAM63A family with sequence similarity 63, member A
FAT1 FAT atypical cadherin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GLTSCR2 glioma tumor suppressor candidate region gene 2
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HNMT histamine N-methyltransferase
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFI27 interferon, alpha-inducible protein 27
IGFBP7 insulin-like growth factor binding protein 7
LAMC2 laminin, gamma 2
LOC100272216 uncharacterized LOC100272216
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAP7 microtubule-associated protein 7
MPO myeloperoxidase
MT1X metallothionein 1X
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A2 nuclear receptor subfamily 4, group A, member 2
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PDGFD platelet derived growth factor D
PILRB paired immunoglobin-like type 2 receptor beta
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POU2AF1 POU class 2 associating factor 1
PRKCD protein kinase C, delta
RPL31 ribosomal protein L31
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SOCS2 suppressor of cytokine signaling 2
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TNS3 tensin 3
TPD52L2 tumor protein D52-like 2
TRIB2 tribbles pseudokinase 2
TST thiosulfate sulfurtransferase (rhodanese)
TXNL4B thioredoxin-like 4B

decreased expression

Symbol Name
AK1 adenylate kinase 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BTG3 BTG family, member 3
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
DCK deoxycytidine kinase
DDIT4 DNA-damage-inducible transcript 4
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM129A family with sequence similarity 129, member A
FCGBP Fc fragment of IgG binding protein
FLG filaggrin
FXYD5 FXYD domain containing ion transport regulator 5
GATA3 GATA binding protein 3
GINS2 GINS complex subunit 2 (Psf2 homolog)
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXB7 homeobox B7
IGKC immunoglobulin kappa constant
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LMNB1 lamin B1
LUM lumican
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MELK maternal embryonic leucine zipper kinase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PECAM1 platelet/endothelial cell adhesion molecule 1
PLK1 polo-like kinase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRC1 protein regulator of cytokinesis 1
PSAT1 phosphoserine aminotransferase 1
PTGES prostaglandin E synthase
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RCAN1 regulator of calcineurin 1
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS1 regulator of G-protein signaling 1
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SHCBP1 SHC SH2-domain binding protein 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMC4 structural maintenance of chromosomes 4
SNAP25 synaptosomal-associated protein, 25kDa
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TAGLN2 transgelin 2
TMEM45A transmembrane protein 45A
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WNT5A wingless-type MMTV integration site family, member 5A