BRD-K02708799_GSK-1059615_LNCAP_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

230 genes differentially expressed following the BRD-K02708799_GSK-1059615_LNCAP_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ATMIN ATM interactor
AZU1 azurocidin 1
BCAM basal cell adhesion molecule (Lutheran blood group)
BHLHE41 basic helix-loop-helix family, member e41
BPTF bromodomain PHD finger transcription factor
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C6ORF62 chromosome 6 open reading frame 62
CADM1 cell adhesion molecule 1
CD163 CD163 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC42BPB CDC42 binding protein kinase beta (DMPK-like)
CDK19 cyclin-dependent kinase 19
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
COL6A2 collagen, type VI, alpha 2
COL9A2 collagen, type IX, alpha 2
CSNK1D casein kinase 1, delta
CST3 cystatin C
DAPK1 death-associated protein kinase 1
DIXDC1 DIX domain containing 1
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
ERBB2 erb-b2 receptor tyrosine kinase 2
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
GAREM GRB2 associated, regulator of MAPK1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GOLGA8H golgin A8 family, member H
GOLGB1 golgin B1
HDAC6 histone deacetylase 6
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HLA-C major histocompatibility complex, class I, C
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IDUA iduronidase, alpha-L-
INSR insulin receptor
IRS2 insulin receptor substrate 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JUND jun D proto-oncogene
KAT6B K(lysine) acetyltransferase 6B
KIZ kizuna centrosomal protein
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LAMA5 laminin, alpha 5
LAMC2 laminin, gamma 2
LAPTM5 lysosomal protein transmembrane 5
LDOC1 leucine zipper, down-regulated in cancer 1
LOC100272216 uncharacterized LOC100272216
LOC100505650 uncharacterized LOC100505650
LOC399491
LYPD3 LY6/PLAUR domain containing 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEF2C myocyte enhancer factor 2C
MZF1 myeloid zinc finger 1
NDRG1 N-myc downstream regulated 1
NNMT nicotinamide N-methyltransferase
NPIPB3 nuclear pore complex interacting protein family, member B3
NUCB1 nucleobindin 1
OBSL1 obscurin-like 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PDE4C phosphodiesterase 4C, cAMP-specific
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLXNB2 plexin B2
PNMA2 paraneoplastic Ma antigen 2
POSTN periostin, osteoblast specific factor
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKCSH protein kinase C substrate 80K-H
PTN pleiotrophin
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBM39 RNA binding motif protein 39
RGS5 regulator of G-protein signaling 5
RHOB ras homolog family member B
RNASET2 ribonuclease T2
RSRP1 arginine/serine-rich protein 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCARB2 scavenger receptor class B, member 2
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC35E2B solute carrier family 35, member E2B
SOCS2 suppressor of cytokine signaling 2
SPATA20 spermatogenesis associated 20
SRGN serglycin
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYNJ2 synaptojanin 2
TACSTD2 tumor-associated calcium signal transducer 2
TGFB1 transforming growth factor, beta 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM45A transmembrane protein 45A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPP1 tripeptidyl peptidase I
TTC3 tetratricopeptide repeat domain 3
TXNIP thioredoxin interacting protein
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
WAC WW domain containing adaptor with coiled-coil
WDR19 WD repeat domain 19
WNK1 WNK lysine deficient protein kinase 1
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
YIPF3 Yip1 domain family, member 3
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36L2 ZFP36 ring finger protein-like 2
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF264 zinc finger protein 264
ZNF292 zinc finger protein 292
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AK4 adenylate kinase 4
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CENPM centromere protein M
CENPU centromere protein U
CHEK2 checkpoint kinase 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCTPP1 dCTP pyrophosphatase 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHFR dihydrofolate reductase
DIO1 deiodinase, iodothyronine, type I
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELOVL6 ELOVL fatty acid elongase 6
EXO1 exonuclease 1
EXOSC8 exosome component 8
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP1 fatty acid binding protein 1, liver
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
GALE UDP-galactose-4-epimerase
GATA3 GATA binding protein 3
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS4 GINS complex subunit 4 (Sld5 homolog)
HIST1H4C histone cluster 1, H4c
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
IL7R interleukin 7 receptor
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
LMNB1 lamin B1
LMO4 LIM domain only 4
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALL mal, T-cell differentiation protein-like
MARS methionyl-tRNA synthetase
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MFAP4 microfibrillar-associated protein 4
MRPS16 mitochondrial ribosomal protein S16
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa
NQO1 NAD(P)H dehydrogenase, quinone 1
NREP neuronal regeneration related protein
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
ORC6 origin recognition complex, subunit 6
PALLD palladin, cytoskeletal associated protein
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PHGDH phosphoglycerate dehydrogenase
PIP prolactin-induced protein
PIR pirin (iron-binding nuclear protein)
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKCH protein kinase C, eta
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RAD51 RAD51 recombinase
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RMI1 RecQ mediated genome instability 1
RNASEH2A ribonuclease H2, subunit A
RRM2 ribonucleotide reductase M2
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SNAP25 synaptosomal-associated protein, 25kDa
SPC25 SPC25, NDC80 kinetochore complex component
STMN1 stathmin 1
STMN2 stathmin 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFRC transferrin receptor
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TRIP13 thyroid hormone receptor interactor 13
VRK1 vaccinia related kinase 1
VTCN1 V-set domain containing T cell activation inhibitor 1
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein