BRD-K02708799_GSK-1059615_HS578T_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

148 genes differentially expressed following the BRD-K02708799_GSK-1059615_HS578T_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ABHD4 abhydrolase domain containing 4
ACPP acid phosphatase, prostate
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOD apolipoprotein D
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CAPG capping protein (actin filament), gelsolin-like
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CNPY3 canopy FGF signaling regulator 3
COL10A1 collagen, type X, alpha 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTIP cytohesin 1 interacting protein
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DPP4 dipeptidyl-peptidase 4
DSP desmoplakin
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA3 EPH receptor A3
FABP4 fatty acid binding protein 4, adipocyte
FGFR1 fibroblast growth factor receptor 1
FNBP1 formin binding protein 1
FZD7 frizzled class receptor 7
GAS1 growth arrest-specific 1
GBP2 guanylate binding protein 2, interferon-inducible
GSN gelsolin
IDS iduronate 2-sulfatase
IER3 immediate early response 3
IGF1 insulin-like growth factor 1 (somatomedin C)
ITGAV integrin, alpha V
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
LGALS8 lectin, galactoside-binding, soluble, 8
LUM lumican
LYPD1 LY6/PLAUR domain containing 1
MAGED1 melanoma antigen family D1
MAP1B microtubule-associated protein 1B
MARCKS myristoylated alanine-rich protein kinase C substrate
MDK midkine (neurite growth-promoting factor 2)
MSMB microseminoprotein, beta-
NEFH neurofilament, heavy polypeptide
NOTCH2NL notch 2 N-terminal like
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PEG10 paternally expressed 10
PPAP2B phosphatidic acid phosphatase type 2B
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSAP prosaposin
PTGIS prostaglandin I2 (prostacyclin) synthase
PTN pleiotrophin
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS2 regulator of G-protein signaling 2
RORA RAR-related orphan receptor A
RPS11 ribosomal protein S11
SAT1 spermidine/spermine N1-acetyltransferase 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SESN1 sestrin 1
SFRP4 secreted frizzled-related protein 4
SOX4 SRY (sex determining region Y)-box 4
SPP1 secreted phosphoprotein 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STX1A syntaxin 1A (brain)
SYNGR3 synaptogyrin 3
SYNM synemin, intermediate filament protein
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIM13 tripartite motif containing 13
TXNIP thioredoxin interacting protein
VAV3 vav 3 guanine nucleotide exchange factor
VTCN1 V-set domain containing T cell activation inhibitor 1
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMD1 adenosylmethionine decarboxylase 1
AREG amphiregulin
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
C1QA complement component 1, q subcomponent, A chain
CCND1 cyclin D1
CDC25A cell division cycle 25A
CLDN7 claudin 7
CLTB clathrin, light chain B
CTSZ cathepsin Z
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL5 chemokine (C-X-C motif) ligand 5
CYCS cytochrome c, somatic
DDIT4 DNA-damage-inducible transcript 4
EGFR epidermal growth factor receptor
EIF5A eukaryotic translation initiation factor 5A
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GSTT1 glutathione S-transferase theta 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
IL1R2 interleukin 1 receptor, type II
IL32 interleukin 32
ITGB1BP1 integrin beta 1 binding protein 1
LAMA3 laminin, alpha 3
LEF1 lymphoid enhancer-binding factor 1
LRRC59 leucine rich repeat containing 59
LYZ lysozyme
MAGEA3 melanoma antigen family A3
MAT2A methionine adenosyltransferase II, alpha
MREG melanoregulin
NCAM1 neural cell adhesion molecule 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPTX2 neuronal pentraxin II
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
PICALM phosphatidylinositol binding clathrin assembly protein
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCH protein kinase C, eta
PSCA prostate stem cell antigen
RASIP1 Ras interacting protein 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SCG5 secretogranin V
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIRT3 sirtuin 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLPI secretory leukocyte peptidase inhibitor
SMAGP small cell adhesion glycoprotein
SRI sorcin
SRSF1 serine/arginine-rich splicing factor 1
TACSTD2 tumor-associated calcium signal transducer 2
TMEM97 transmembrane protein 97
TMSB15A thymosin beta 15a
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TSPAN8 tetraspanin 8
TTC39A tetratricopeptide repeat domain 39A
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1
ZFP36L2 ZFP36 ring finger protein-like 2