BRD-K02708799_GSK-1059615_HS578T_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

154 genes differentially expressed following the BRD-K02708799_GSK-1059615_HS578T_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ANKRD10 ankyrin repeat domain 10
ANKRD36B ankyrin repeat domain 36B
APOD apolipoprotein D
ASS1 argininosuccinate synthase 1
BTG2 BTG family, member 2
CA12 carbonic anhydrase XII
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNG2 cyclin G2
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFD complement factor D (adipsin)
CGA glycoprotein hormones, alpha polypeptide
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL14A1 collagen, type XIV, alpha 1
CPE carboxypeptidase E
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CTSK cathepsin K
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DKFZP586I1420 uncharacterized protein DKFZp586I1420
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPT dermatopontin
DSP desmoplakin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F13A1 coagulation factor XIII, A1 polypeptide
FCGBP Fc fragment of IgG binding protein
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FRZB frizzled-related protein
G0S2 G0/G1 switch 2
GDF15 growth differentiation factor 15
GOLGA8A golgin A8 family, member A
GUSBP11 glucuronidase, beta pseudogene 11
HACD3 3-hydroxyacyl-CoA dehydratase 3
HES1 hes family bHLH transcription factor 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
KDM3A lysine (K)-specific demethylase 3A
KLHL21 kelch-like family member 21
KRT17 keratin 17, type I
LAMA3 laminin, alpha 3
LAMP5 lysosomal-associated membrane protein family, member 5
LGALS3 lectin, galactoside-binding, soluble, 3
LMO3 LIM domain only 3 (rhombotin-like 2)
LTF lactotransferrin
LUM lumican
MMP9 matrix metallopeptidase 9
MTSS1 metastasis suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXRA5 matrix-remodelling associated 5
N4BP2L2 NEDD4 binding protein 2-like 2
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NOX4 NADPH oxidase 4
OGN osteoglycin
OSBPL3 oxysterol binding protein-like 3
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLTP phospholipid transfer protein
POU2AF1 POU class 2 associating factor 1
PTCH1 patched 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RALGDS ral guanine nucleotide dissociation stimulator
RBP4 retinol binding protein 4, plasma
RGS1 regulator of G-protein signaling 1
S100P S100 calcium binding protein P
SATB2 SATB homeobox 2
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SOX4 SRY (sex determining region Y)-box 4
SPARCL1 SPARC-like 1 (hevin)
SPP1 secreted phosphoprotein 1
SRGN serglycin
STON1 stonin 1
STX1A syntaxin 1A (brain)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TFF1 trefoil factor 1
TGFBR3 transforming growth factor, beta receptor III
THBS1 thrombospondin 1
TNC tenascin C
VTCN1 V-set domain containing T cell activation inhibitor 1
WWTR1 WW domain containing transcription regulator 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
ANXA3 annexin A3
APP amyloid beta (A4) precursor protein
AQP9 aquaporin 9
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL4C ADP-ribosylation factor-like 4C
ASPH aspartate beta-hydroxylase
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BASP1 brain abundant, membrane attached signal protein 1
CCND1 cyclin D1
CCND3 cyclin D3
CD59 CD59 molecule, complement regulatory protein
CD81 CD81 molecule
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
COL1A2 collagen, type I, alpha 2
CREB1 cAMP responsive element binding protein 1
CSRP2 cysteine and glycine-rich protein 2
CTSZ cathepsin Z
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
ECM1 extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
EMX2 empty spiracles homeobox 2
ERAP2 endoplasmic reticulum aminopeptidase 2
ERO1L ERO1-like (S. cerevisiae)
ETV5 ets variant 5
FABP6 fatty acid binding protein 6, ileal
FKBP14 FK506 binding protein 14, 22 kDa
FOSL1 FOS-like antigen 1
FSTL1 follistatin-like 1
GNAS GNAS complex locus
GRB7 growth factor receptor-bound protein 7
GSTT1 glutathione S-transferase theta 1
HIST1H4C histone cluster 1, H4c
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
KDM5D lysine (K)-specific demethylase 5D
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
LMO2 LIM domain only 2 (rhombotin-like 1)
LRRC59 leucine rich repeat containing 59
MSMO1 methylsterol monooxygenase 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHB prohibitin
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
PKM pyruvate kinase, muscle
RGCC regulator of cell cycle
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TACSTD2 tumor-associated calcium signal transducer 2
TNS1 tensin 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon