BRD-K02708799_GSK-1059615_HS578T_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

308 genes differentially expressed following the BRD-K02708799_GSK-1059615_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAM28 ADAM metallopeptidase domain 28
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADCK3 aarF domain containing kinase 3
ADGRF5 adhesion G protein-coupled receptor F5
ADIRF adipogenesis regulatory factor
AMIGO2 adhesion molecule with Ig-like domain 2
ANGPTL2 angiopoietin-like 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD36B ankyrin repeat domain 36B
AOX1 aldehyde oxidase 1
APOD apolipoprotein D
AREG amphiregulin
ASPN asporin
ASS1 argininosuccinate synthase 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BID BH3 interacting domain death agonist
BLNK B-cell linker
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
C6ORF62 chromosome 6 open reading frame 62
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CCND1 cyclin D1
CCNG2 cyclin G2
CD22 CD22 molecule
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CDC25B cell division cycle 25B
CDK19 cyclin-dependent kinase 19
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN2 chimerin 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN8 claudin 8
CLEC2B C-type lectin domain family 2, member B
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTBP2 C-terminal binding protein 2
CTGF connective tissue growth factor
CYTH1 cytohesin 1
DEFA4 defensin, alpha 4, corticostatin
DEPTOR DEP domain containing MTOR-interacting protein
DIAPH2 diaphanous-related formin 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DLX2 distal-less homeobox 2
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EGR3 early growth response 3
EPCAM epithelial cell adhesion molecule
EPHA3 EPH receptor A3
EPS8 epidermal growth factor receptor pathway substrate 8
EREG epiregulin
F13A1 coagulation factor XIII, A1 polypeptide
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM49A family with sequence similarity 49, member A
FAM60A family with sequence similarity 60, member A
FAM8A1 family with sequence similarity 8, member A1
FGF13 fibroblast growth factor 13
FGG fibrinogen gamma chain
FN1 fibronectin 1
FOXO4 forkhead box O4
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
FZD5 frizzled class receptor 5
FZD7 frizzled class receptor 7
GAA glucosidase, alpha; acid
GAB2 GRB2-associated binding protein 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GDF15 growth differentiation factor 15
GLUL glutamate-ammonia ligase
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPX3 glutathione peroxidase 3
GSN gelsolin
HBP1 HMG-box transcription factor 1
HDAC6 histone deacetylase 6
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HMGA2 high mobility group AT-hook 2
HOMER3 homer scaffolding protein 3
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGBP1 immunoglobulin (CD79A) binding protein 1
IGFBP1 insulin-like growth factor binding protein 1
IGFBP5 insulin-like growth factor binding protein 5
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL6 interleukin 6
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGAV integrin, alpha V
IVNS1ABP influenza virus NS1A binding protein
KLHL24 kelch-like family member 24
LMO2 LIM domain only 2 (rhombotin-like 1)
LOC100272216 uncharacterized LOC100272216
LXN latexin
MAN2A1 mannosidase, alpha, class 2A, member 1
MDFIC MyoD family inhibitor domain containing
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MEF2C myocyte enhancer factor 2C
MGP matrix Gla protein
MXRA7 matrix-remodelling associated 7
NOX4 NADPH oxidase 4
NPIPB3 nuclear pore complex interacting protein family, member B3
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PARP8 poly (ADP-ribose) polymerase family, member 8
PDE4B phosphodiesterase 4B, cAMP-specific
PEG3 paternally expressed 3
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PILRB paired immunoglobin-like type 2 receptor beta
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLIN2 perilipin 2
PLK2 polo-like kinase 2
POSTN periostin, osteoblast specific factor
PRKCQ protein kinase C, theta
PTN pleiotrophin
RAP1GAP2 RAP1 GTPase activating protein 2
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RGS2 regulator of G-protein signaling 2
RNASET2 ribonuclease T2
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SEPT4 septin 4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SH3YL1 SH3 and SYLF domain containing 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC35E2B solute carrier family 35, member E2B
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMAD3 SMAD family member 3
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
STON1 stonin 1
STX1A syntaxin 1A (brain)
SYNM synemin, intermediate filament protein
TANK TRAF family member-associated NFKB activator
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TMPRSS3 transmembrane protease, serine 3
TNNT1 troponin T type 1 (skeletal, slow)
TPBG trophoblast glycoprotein
TRAK2 trafficking protein, kinesin binding 2
TRIM13 tripartite motif containing 13
TRPS1 trichorhinophalangeal syndrome I
TSTA3 tissue specific transplantation antigen P35B
TTC3 tetratricopeptide repeat domain 3
TXNIP thioredoxin interacting protein
UBE2B ubiquitin-conjugating enzyme E2B
USP34 ubiquitin specific peptidase 34
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican
VEGFC vascular endothelial growth factor C
VNN1 vanin 1
WDR37 WD repeat domain 37
WDR45 WD repeat domain 45
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDOA aldolase A, fructose-bisphosphate
ANXA6 annexin A6
AQP3 aquaporin 3 (Gill blood group)
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ASCC3 activating signal cointegrator 1 complex subunit 3
ATF6 activating transcription factor 6
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BANF1 barrier to autointegration factor 1
BCHE butyrylcholinesterase
BLVRA biliverdin reductase A
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BST2 bone marrow stromal cell antigen 2
CADM1 cell adhesion molecule 1
CCND3 cyclin D3
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CENPU centromere protein U
CHEK2 checkpoint kinase 2
CHI3L2 chitinase 3-like 2
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
COL5A1 collagen, type V, alpha 1
CTPS1 CTP synthase 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYB5A cytochrome b5 type A (microsomal)
CYCS cytochrome c, somatic
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EBP emopamil binding protein (sterol isomerase)
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELOVL6 ELOVL fatty acid elongase 6
EMP3 epithelial membrane protein 3
ENO1 enolase 1, (alpha)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FEN1 flap structure-specific endonuclease 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FKBP14 FK506 binding protein 14, 22 kDa
FOLR1 folate receptor 1 (adult)
GALE UDP-galactose-4-epimerase
GBP1 guanylate binding protein 1, interferon-inducible
GFOD1 glucose-fructose oxidoreductase domain containing 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSTP1 glutathione S-transferase pi 1
GTF2A2 general transcription factor IIA, 2, 12kDa
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HLA-B major histocompatibility complex, class I, B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12
IDI1 isopentenyl-diphosphate delta isomerase 1
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL32 interleukin 32
ISG15 ISG15 ubiquitin-like modifier
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT7 keratin 7, type II
LAMP3 lysosomal-associated membrane protein 3
LAPTM4B lysosomal protein transmembrane 4 beta
LIMCH1 LIM and calponin homology domains 1
LYPLA1 lysophospholipase I
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MLEC malectin
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC5B mucin 5B, oligomeric mucus/gel-forming
NKX3-1 NK3 homeobox 1
NNMT nicotinamide N-methyltransferase
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PGAM1 phosphoglycerate mutase 1 (brain)
PGD phosphogluconate dehydrogenase
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRDX1 peroxiredoxin 1
PRMT1 protein arginine methyltransferase 1
PRPS1 phosphoribosyl pyrophosphate synthetase 1
RCAN1 regulator of calcineurin 1
RGS1 regulator of G-protein signaling 1
S100A11 S100 calcium binding protein A11
S100A2 S100 calcium binding protein A2
S100A4 S100 calcium binding protein A4
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SQLE squalene epoxidase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGN serglycin
STAT1 signal transducer and activator of transcription 1, 91kDa
SUB1 SUB1 homolog (S. cerevisiae)
TAGLN2 transgelin 2
TARS threonyl-tRNA synthetase
TDO2 tryptophan 2,3-dioxygenase
TMEM176B transmembrane protein 176B
TMEM47 transmembrane protein 47
TMEM97 transmembrane protein 97
TNC tenascin C
TSKU tsukushi, small leucine rich proteoglycan
TXN thioredoxin
UPP1 uridine phosphorylase 1
WARS tryptophanyl-tRNA synthetase
WFDC2 WAP four-disulfide core domain 2
WNT5A wingless-type MMTV integration site family, member 5A