BRD-K02708799_GSK-1059615_HS578T_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

343 genes differentially expressed following the BRD-K02708799_GSK-1059615_HS578T_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADAM28 ADAM metallopeptidase domain 28
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADRB2 adrenoceptor beta 2, surface
ANKRD36B ankyrin repeat domain 36B
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
APOD apolipoprotein D
ARG2 arginase 2
ASPN asporin
ASS1 argininosuccinate synthase 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BID BH3 interacting domain death agonist
BLNK B-cell linker
BTG2 BTG family, member 2
C6ORF48 chromosome 6 open reading frame 48
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL20 chemokine (C-C motif) ligand 20
CD300A CD300a molecule
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CDC25B cell division cycle 25B
CDK19 cyclin-dependent kinase 19
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHN2 chimerin 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLDN8 claudin 8
CLEC2B C-type lectin domain family 2, member B
COL2A1 collagen, type II, alpha 1
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CSF1R colony stimulating factor 1 receptor
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYTH1 cytohesin 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DENND1B DENN/MADD domain containing 1B
DIAPH2 diaphanous-related formin 2
DLK1 delta-like 1 homolog (Drosophila)
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DOCK4 dedicator of cytokinesis 4
DOCK9 dedicator of cytokinesis 9
DPP4 dipeptidyl-peptidase 4
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
ERBB4 erb-b2 receptor tyrosine kinase 4
F13A1 coagulation factor XIII, A1 polypeptide
F5 coagulation factor V (proaccelerin, labile factor)
FN1 fibronectin 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXD1 forkhead box D1
FOXO4 forkhead box O4
FZD5 frizzled class receptor 5
G0S2 G0/G1 switch 2
GAB2 GRB2-associated binding protein 2
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GOLGA8A golgin A8 family, member A
GPNMB glycoprotein (transmembrane) nmb
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GSE1 Gse1 coiled-coil protein
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HDAC6 histone deacetylase 6
HDAC9 histone deacetylase 9
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGA2 high mobility group AT-hook 2
HMGN4 high mobility group nucleosomal binding domain 4
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IDS iduronate 2-sulfatase
IDUA iduronidase, alpha-L-
IL10RA interleukin 10 receptor, alpha
INSR insulin receptor
IQCE IQ motif containing E
IRF6 interferon regulatory factor 6
IRS1 insulin receptor substrate 1
KDM5D lysine (K)-specific demethylase 5D
KDM7A lysine (K)-specific demethylase 7A
KIF5C kinesin family member 5C
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
LETMD1 LETM1 domain containing 1
LGALS8 lectin, galactoside-binding, soluble, 8
LOC399491
LPAR6 lysophosphatidic acid receptor 6
LRMP lymphoid-restricted membrane protein
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEB2 melanoma antigen family B2
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2A1 mannosidase, alpha, class 2A, member 1
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MED13L mediator complex subunit 13-like
MIR22HG MIR22 host gene
MMD monocyte to macrophage differentiation-associated
MTMR11 myotubularin related protein 11
MXRA7 matrix-remodelling associated 7
N4BP2L1 NEDD4 binding protein 2-like 1
NINL ninein-like
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTS neurotensin
OSBPL3 oxysterol binding protein-like 3
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PCDH9 protocadherin 9
PDE9A phosphodiesterase 9A
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PEG3 paternally expressed 3
PHIP pleckstrin homology domain interacting protein
PHYH phytanoyl-CoA 2-hydroxylase
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PILRB paired immunoglobin-like type 2 receptor beta
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PNKP polynucleotide kinase 3'-phosphatase
PRKCH protein kinase C, eta
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PTPRO protein tyrosine phosphatase, receptor type, O
RABGAP1L RAB GTPase activating protein 1-like
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RGCC regulator of cell cycle
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RGS10 regulator of G-protein signaling 10
RGS17 regulator of G-protein signaling 17
RGS2 regulator of G-protein signaling 2
RNASE6 ribonuclease, RNase A family, k6
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD5 stearoyl-CoA desaturase 5
SCGB2A2 secretoglobin, family 2A, member 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SF1 splicing factor 1
SIK3 SIK family kinase 3
SLC38A1 solute carrier family 38, member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
ST18 suppression of tumorigenicity 18, zinc finger
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STX1A syntaxin 1A (brain)
STXBP2 syntaxin binding protein 2
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYK spleen tyrosine kinase
SYNGR3 synaptogyrin 3
SYT1 synaptotagmin I
TEX10 testis expressed 10
TF transferrin
TFF1 trefoil factor 1
TMEM30B transmembrane protein 30B
TNC tenascin C
TREM1 triggering receptor expressed on myeloid cells 1
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TRPS1 trichorhinophalangeal syndrome I
TSTA3 tissue specific transplantation antigen P35B
USP34 ubiquitin specific peptidase 34
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican
VNN1 vanin 1
XIST X inactive specific transcript (non-protein coding)
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF195 zinc finger protein 195
ZNF292 zinc finger protein 292
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACTB actin, beta
AK1 adenylate kinase 1
AK2 adenylate kinase 2
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDOA aldolase A, fructose-bisphosphate
ANXA6 annexin A6
ASPH aspartate beta-hydroxylase
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
BAG2 BCL2-associated athanogene 2
BCHE butyrylcholinesterase
BIN1 bridging integrator 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BST2 bone marrow stromal cell antigen 2
C1QA complement component 1, q subcomponent, A chain
CALML5 calmodulin-like 5
CCND2 cyclin D2
CD59 CD59 molecule, complement regulatory protein
CDC42 cell division cycle 42
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFH complement factor H
CKAP4 cytoskeleton-associated protein 4
CLIC3 chloride intracellular channel 3
CLU clusterin
COL5A1 collagen, type V, alpha 1
CSRP1 cysteine and glycine-rich protein 1
CTBP2 C-terminal binding protein 2
CTSC cathepsin C
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5A cytochrome b5 type A (microsomal)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DACH1 dachshund family transcription factor 1
DCTPP1 dCTP pyrophosphatase 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
ECM1 extracellular matrix protein 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
EMP3 epithelial membrane protein 3
ENO1 enolase 1, (alpha)
ERAP2 endoplasmic reticulum aminopeptidase 2
FADS1 fatty acid desaturase 1
FAM162A family with sequence similarity 162, member A
FBXO21 F-box protein 21
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGFR2 fibroblast growth factor receptor 2
FKBP14 FK506 binding protein 14, 22 kDa
FLNA filamin A, alpha
FSTL1 follistatin-like 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GALE UDP-galactose-4-epimerase
GAS1 growth arrest-specific 1
GBP1 guanylate binding protein 1, interferon-inducible
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GPM6B glycoprotein M6B
GPX2 glutathione peroxidase 2
GSTM3 glutathione S-transferase mu 3 (brain)
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
H2AFZ H2A histone family, member Z
HEG1 heart development protein with EGF-like domains 1
HELLS helicase, lymphoid-specific
HLA-B major histocompatibility complex, class I, B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPB8 heat shock 22kDa protein 8
IARS isoleucyl-tRNA synthetase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIAA0101 KIAA0101
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
L1TD1 LINE-1 type transposase domain containing 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMCH1 LIM and calponin homology domains 1
LRRC17 leucine rich repeat containing 17
LY6D lymphocyte antigen 6 complex, locus D
LYPLA1 lysophospholipase I
MATN2 matrilin 2
MB myoglobin
MLEC malectin
MMP12 matrix metallopeptidase 12
MSMO1 methylsterol monooxygenase 1
MYCBP MYC binding protein
NBL1 neuroblastoma 1, DAN family BMP antagonist
NEFL neurofilament, light polypeptide
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NOTCH2 notch 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OLFM4 olfactomedin 4
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PALLD palladin, cytoskeletal associated protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBK PDZ binding kinase
PBX1 pre-B-cell leukemia homeobox 1
PCNA proliferating cell nuclear antigen
PCP4 Purkinje cell protein 4
PDGFRL platelet-derived growth factor receptor-like
PDLIM2 PDZ and LIM domain 2 (mystique)
PEX11A peroxisomal biogenesis factor 11 alpha
PGAM1 phosphoglycerate mutase 1 (brain)
PGD phosphogluconate dehydrogenase
PGK1 phosphoglycerate kinase 1
PHB prohibitin
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRDX1 peroxiredoxin 1
PSIP1 PC4 and SFRS1 interacting protein 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSPH phosphoserine phosphatase
PYCARD PYD and CARD domain containing
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RGS1 regulator of G-protein signaling 1
RPN2 ribophorin II
S100A2 S100 calcium binding protein A2
S100A4 S100 calcium binding protein A4
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERBP1 SERPINE1 mRNA binding protein 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SRGN serglycin
STAT1 signal transducer and activator of transcription 1, 91kDa
STK10 serine/threonine kinase 10
TACSTD2 tumor-associated calcium signal transducer 2
TMEM14A transmembrane protein 14A
TMEM255A transmembrane protein 255A
TMEM47 transmembrane protein 47
TMEM97 transmembrane protein 97
TRIM16 tripartite motif containing 16
TSPAN3 tetraspanin 3
TSPAN4 tetraspanin 4
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
ZDHHC6 zinc finger, DHHC-type containing 6