BRD-K02708799_GSK-1059615_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

261 genes differentially expressed following the BRD-K02708799_GSK-1059615_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADAM28 ADAM metallopeptidase domain 28
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADRB2 adrenoceptor beta 2, surface
ALDOB aldolase B, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
AMOTL2 angiomotin like 2
ANGPTL2 angiopoietin-like 2
ANKRD36B ankyrin repeat domain 36B
AOX1 aldehyde oxidase 1
APOD apolipoprotein D
AREG amphiregulin
ARID5B AT rich interactive domain 5B (MRF1-like)
ASMTL acetylserotonin O-methyltransferase-like
ASPN asporin
ATP9A ATPase, class II, type 9A
BIRC3 baculoviral IAP repeat containing 3
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES2 carboxylesterase 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN8 claudin 8
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL11A1 collagen, type XI, alpha 1
COL3A1 collagen, type III, alpha 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
DCN decorin
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DRAM1 DNA-damage regulated autophagy modulator 1
DSP desmoplakin
DST dystonin
ECHDC2 enoyl CoA hydratase domain containing 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
ETV1 ets variant 1
EVI2A ecotropic viral integration site 2A
F13A1 coagulation factor XIII, A1 polypeptide
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FAM8A1 family with sequence similarity 8, member A1
FAS Fas cell surface death receptor
FASTKD5 FAST kinase domains 5
FGF13 fibroblast growth factor 13
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FOXO4 forkhead box O4
FZD5 frizzled class receptor 5
G0S2 G0/G1 switch 2
GAB2 GRB2-associated binding protein 2
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GEM GTP binding protein overexpressed in skeletal muscle
GRAMD3 GRAM domain containing 3
GRB14 growth factor receptor-bound protein 14
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HOXD1 homeobox D1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGAV integrin, alpha V
KCTD12 potassium channel tetramerization domain containing 12
KCTD5 potassium channel tetramerization domain containing 5
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
KLRB1 killer cell lectin-like receptor subfamily B, member 1
KRT18 keratin 18, type I
LAMA2 laminin, alpha 2
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LDLR low density lipoprotein receptor
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LXN latexin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2A1 mannosidase, alpha, class 2A, member 1
MAPT microtubule-associated protein tau
MIR22HG MIR22 host gene
MMP9 matrix metallopeptidase 9
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
MYO5C myosin VC
MYO6 myosin VI
N4BP2L1 NEDD4 binding protein 2-like 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFC platelet derived growth factor C
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PLAGL1 pleiomorphic adenoma gene-like 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHA5 pleckstrin homology domain containing, family A member 5
POSTN periostin, osteoblast specific factor
PROM1 prominin 1
PROS1 protein S (alpha)
PSD3 pleckstrin and Sec7 domain containing 3
PTPRO protein tyrosine phosphatase, receptor type, O
R3HDM4 R3H domain containing 4
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNASET2 ribonuclease T2
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCD5 stearoyl-CoA desaturase 5
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SF1 splicing factor 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOS2 son of sevenless homolog 2 (Drosophila)
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SPINK1 serine peptidase inhibitor, Kazal type 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPON2 spondin 2, extracellular matrix protein
SPP1 secreted phosphoprotein 1
SRRM2 serine/arginine repetitive matrix 2
STC1 stanniocalcin 1
SUGCT succinyl-CoA:glutarate-CoA transferase
SULF1 sulfatase 1
SYNGR3 synaptogyrin 3
SYT1 synaptotagmin I
TFF1 trefoil factor 1
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TLR4 toll-like receptor 4
TRPS1 trichorhinophalangeal syndrome I
TXNIP thioredoxin interacting protein
VCAN versican
VNN1 vanin 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDOA aldolase A, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ATF5 activating transcription factor 5
BASP1 brain abundant, membrane attached signal protein 1
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BRCA1 breast cancer 1, early onset
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CES1 carboxylesterase 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT4 DNA-damage-inducible transcript 4
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EFHD2 EF-hand domain family, member D2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
EMP3 epithelial membrane protein 3
ENO1 enolase 1, (alpha)
ERAP2 endoplasmic reticulum aminopeptidase 2
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FBXO11 F-box protein 11
FEN1 flap structure-specific endonuclease 1
GALE UDP-galactose-4-epimerase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPI glucose-6-phosphate isomerase
HELLS helicase, lymphoid-specific
HILPDA hypoxia inducible lipid droplet-associated
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IL1RN interleukin 1 receptor antagonist
KIAA0101 KIAA0101
KRT4 keratin 4, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LIG1 ligase I, DNA, ATP-dependent
LTF lactotransferrin
MALL mal, T-cell differentiation protein-like
MCAM melanoma cell adhesion molecule
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MICALL1 MICAL-like 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NXN nucleoredoxin
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PCP4 Purkinje cell protein 4
PEX11A peroxisomal biogenesis factor 11 alpha
PGD phosphogluconate dehydrogenase
PHB prohibitin
PHGDH phosphoglycerate dehydrogenase
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKCH protein kinase C, eta
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
RFC2 replication factor C (activator 1) 2, 40kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SDC4 syndecan 4
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SHCBP1 SHC SH2-domain binding protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLPI secretory leukocyte peptidase inhibitor
SNAP25 synaptosomal-associated protein, 25kDa
SPTSSA serine palmitoyltransferase, small subunit A
STAT1 signal transducer and activator of transcription 1, 91kDa
STK10 serine/threonine kinase 10
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAGLN2 transgelin 2
TK1 thymidine kinase 1, soluble
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
UPP1 uridine phosphorylase 1
WARS tryptophanyl-tRNA synthetase
ZDHHC6 zinc finger, DHHC-type containing 6
ZWINT ZW10 interacting kinetochore protein