BRD-K02708799_GSK-1059615_HS578T_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

206 genes differentially expressed following the BRD-K02708799_GSK-1059615_HS578T_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACTA2 actin, alpha 2, smooth muscle, aorta
ADIRF adipogenesis regulatory factor
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ANGPT1 angiopoietin 1
ANGPTL2 angiopoietin-like 2
ANKRD10 ankyrin repeat domain 10
AREG amphiregulin
ARID5B AT rich interactive domain 5B (MRF1-like)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATXN1 ataxin 1
BRD2 bromodomain containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
CADM1 cell adhesion molecule 1
CD46 CD46 molecule, complement regulatory protein
CD9 CD9 molecule
CLIC5 chloride intracellular channel 5
COL18A1 collagen, type XVIII, alpha 1
CPE carboxypeptidase E
CTGF connective tissue growth factor
CTSH cathepsin H
CXCR4 chemokine (C-X-C motif) receptor 4
DDR1 discoidin domain receptor tyrosine kinase 1
DICER1 dicer 1, ribonuclease type III
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
EPHA3 EPH receptor A3
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FAM114A1 family with sequence similarity 114, member A1
FAM171A1 family with sequence similarity 171, member A1
FHL1 four and a half LIM domains 1
FLRT3 fibronectin leucine rich transmembrane protein 3
FN1 fibronectin 1
FOXO4 forkhead box O4
G0S2 G0/G1 switch 2
GATA6 GATA binding protein 6
GLUL glutamate-ammonia ligase
GNB5 guanine nucleotide binding protein (G protein), beta 5
GPC4 glypican 4
GPX3 glutathione peroxidase 3
GRB7 growth factor receptor-bound protein 7
GRN granulin
GSE1 Gse1 coiled-coil protein
HIST1H2AC histone cluster 1, H2ac
HLA-E major histocompatibility complex, class I, E
IFI6 interferon, alpha-inducible protein 6
IGHM immunoglobulin heavy constant mu
INHBB inhibin, beta B
IRS1 insulin receptor substrate 1
KRT23 keratin 23, type I
LDLR low density lipoprotein receptor
LEPROT leptin receptor overlapping transcript
LTBP3 latent transforming growth factor beta binding protein 3
MATN2 matrilin 2
MT1F metallothionein 1F
MTSS1 metastasis suppressor 1
NELL2 NEL-like 2 (chicken)
NGRN neugrin, neurite outgrowth associated
NMT2 N-myristoyltransferase 2
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PDZD2 PDZ domain containing 2
PEG10 paternally expressed 10
PFKL phosphofructokinase, liver
POSTN periostin, osteoblast specific factor
PROM1 prominin 1
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAD51C RAD51 paralog C
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
REEP1 receptor accessory protein 1
RGS13 regulator of G-protein signaling 13
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SCYL3 SCY1-like 3 (S. cerevisiae)
SDC2 syndecan 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGCE sarcoglycan, epsilon
SH3BGRL SH3 domain binding glutamate-rich protein like
SIDT2 SID1 transmembrane family, member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC38A1 solute carrier family 38, member 1
SOX9 SRY (sex determining region Y)-box 9
SPATA20 spermatogenesis associated 20
SSBP2 single-stranded DNA binding protein 2
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAR steroidogenic acute regulatory protein
SYT1 synaptotagmin I
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
THBS1 thrombospondin 1
THSD7A thrombospondin, type I, domain containing 7A
TXNIP thioredoxin interacting protein
VCAN versican
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)

decreased expression

Symbol Name
AK2 adenylate kinase 2
ALOX5 arachidonate 5-lipoxygenase
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
ATF5 activating transcription factor 5
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BRCA1 breast cancer 1, early onset
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CFH complement factor H
CKS2 CDC28 protein kinase regulatory subunit 2
CTBP2 C-terminal binding protein 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYCS cytochrome c, somatic
DCK deoxycytidine kinase
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECT2 epithelial cell transforming 2
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERAP2 endoplasmic reticulum aminopeptidase 2
ESR1 estrogen receptor 1
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GALE UDP-galactose-4-epimerase
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GMNN geminin, DNA replication inhibitor
GRIA2 glutamate receptor, ionotropic, AMPA 2
GTSE1 G-2 and S-phase expressed 1
HK2 hexokinase 2
KIAA0101 KIAA0101
KIF18B kinesin family member 18B
KLF4 Kruppel-like factor 4 (gut)
KRT13 keratin 13, type I
KRT19 keratin 19, type I
LEF1 lymphoid enhancer-binding factor 1
LMNB1 lamin B1
LTF lactotransferrin
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP12 matrix metallopeptidase 12
MPPED2 metallophosphoesterase domain containing 2
MSH2 mutS homolog 2
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NDC1 NDC1 transmembrane nucleoporin
NET1 neuroepithelial cell transforming 1
ORC6 origin recognition complex, subunit 6
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLS1 plastin 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRPF4 pre-mRNA processing factor 4
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SFRP4 secreted frizzled-related protein 4
SHCBP1 SHC SH2-domain binding protein 1
SMC2 structural maintenance of chromosomes 2
SRGN serglycin
STC1 stanniocalcin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TDO2 tryptophan 2,3-dioxygenase
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIM16 tripartite motif containing 16
TSPYL5 TSPY-like 5
TUBG1 tubulin, gamma 1
UBE2C ubiquitin-conjugating enzyme E2C
USP1 ubiquitin specific peptidase 1
ZWINT ZW10 interacting kinetochore protein