BRD-K02708799_GSK-1059615_HME1_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

147 genes differentially expressed following the BRD-K02708799_GSK-1059615_HME1_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKR1C3 aldo-keto reductase family 1, member C3
ANKRD10 ankyrin repeat domain 10
ARL4A ADP-ribosylation factor-like 4A
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C8ORF4 chromosome 8 open reading frame 4
CCNG2 cyclin G2
CD302 CD302 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CNR1 cannabinoid receptor 1 (brain)
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPHA4 EPH receptor A4
FAM129A family with sequence similarity 129, member A
FNBP1 formin binding protein 1
FRZB frizzled-related protein
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IRS2 insulin receptor substrate 2
JCHAIN joining chain of multimeric IgA and IgM
KIAA0907 KIAA0907
KRT19 keratin 19, type I
LETMD1 LETM1 domain containing 1
LOC100505650 uncharacterized LOC100505650
LUM lumican
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MDFIC MyoD family inhibitor domain containing
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MGP matrix Gla protein
N4BP2L2 NEDD4 binding protein 2-like 2
NBPF10 neuroblastoma breakpoint family, member 10
NCOA2 nuclear receptor coactivator 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH2NL notch 2 N-terminal like
NPY1R neuropeptide Y receptor Y1
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL1A oxysterol binding protein-like 1A
PEG10 paternally expressed 10
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
POSTN periostin, osteoblast specific factor
PRUNE2 prune homolog 2 (Drosophila)
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RGS2 regulator of G-protein signaling 2
RNASE6 ribonuclease, RNase A family, k6
RSRP1 arginine/serine-rich protein 1
SLC35E2B solute carrier family 35, member E2B
SLC38A2 solute carrier family 38, member 2
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOX4 SRY (sex determining region Y)-box 4
SRSF7 serine/arginine-rich splicing factor 7
STX1A syntaxin 1A (brain)
SYT1 synaptotagmin I
TARBP1 TAR (HIV-1) RNA binding protein 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOB1 transducer of ERBB2, 1
TPBG trophoblast glycoprotein
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
WARS tryptophanyl-tRNA synthetase
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ANXA3 annexin A3
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
CBFB core-binding factor, beta subunit
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CDC25A cell division cycle 25A
CDK6 cyclin-dependent kinase 6
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CNN2 calponin 2
CSNK1E casein kinase 1, epsilon
CXCL8 chemokine (C-X-C motif) ligand 8
DUSP14 dual specificity phosphatase 14
EIF5A eukaryotic translation initiation factor 5A
ELAVL1 ELAV like RNA binding protein 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
HAS2 hyaluronan synthase 2
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HK2 hexokinase 2
HMGA2 high mobility group AT-hook 2
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
INHBA inhibin, beta A
ITGA6 integrin, alpha 6
KRT13 keratin 13, type I
KRT4 keratin 4, type II
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP2K3 mitogen-activated protein kinase kinase 3
MAT2A methionine adenosyltransferase II, alpha
MME membrane metallo-endopeptidase
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
OLFM4 olfactomedin 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PNP purine nucleoside phosphorylase
PPIF peptidylprolyl isomerase F
PRKCD protein kinase C, delta
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RCAN1 regulator of calcineurin 1
S100A7 S100 calcium binding protein A7
SDC4 syndecan 4
SERINC5 serine incorporator 5
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAGP small cell adhesion glycoprotein
SPP1 secreted phosphoprotein 1
SPRR1A small proline-rich protein 1A
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
STC1 stanniocalcin 1
TGFA transforming growth factor, alpha
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A