BRD-K02708799_GSK-1059615_HME1_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

207 genes differentially expressed following the BRD-K02708799_GSK-1059615_HME1_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKR1C3 aldo-keto reductase family 1, member C3
ANKRD10 ankyrin repeat domain 10
ARGLU1 arginine and glutamate rich 1
ASCL1 achaete-scute family bHLH transcription factor 1
ATF4 activating transcription factor 4
BCHE butyrylcholinesterase
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
CA12 carbonic anhydrase XII
CBS cystathionine-beta-synthase
CCNL2 cyclin L2
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDR2 discoidin domain receptor tyrosine kinase 2
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DKFZP586I1420 uncharacterized protein DKFZp586I1420
FHL1 four and a half LIM domains 1
FRZB frizzled-related protein
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
H2BFS H2B histone family, member S (pseudogene)
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
IFRD1 interferon-related developmental regulator 1
IGL immunoglobulin lambda locus
KIAA0907 KIAA0907
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LAP3 leucine aminopeptidase 3
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
MATN2 matrilin 2
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MXRA5 matrix-remodelling associated 5
NACA nascent polypeptide-associated complex alpha subunit
NBPF10 neuroblastoma breakpoint family, member 10
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
NVL nuclear VCP-like
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OLFM1 olfactomedin 1
OPN3 opsin 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PBX1 pre-B-cell leukemia homeobox 1
PCBP2 poly(rC) binding protein 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDE1A phosphodiesterase 1A, calmodulin-dependent
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
POSTN periostin, osteoblast specific factor
PTGIS prostaglandin I2 (prostacyclin) synthase
QPRT quinolinate phosphoribosyltransferase
REEP1 receptor accessory protein 1
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RPL10 ribosomal protein L10
RSRP1 arginine/serine-rich protein 1
SCG2 secretogranin II
SEPW1 selenoprotein W, 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC35E2B solute carrier family 35, member E2B
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPG11 spastic paraplegia 11 (autosomal recessive)
SST somatostatin
STX1A syntaxin 1A (brain)
TPCN1 two pore segment channel 1
TRA2A transformer 2 alpha homolog (Drosophila)
TSC22D3 TSC22 domain family, member 3
WISP2 WNT1 inducible signaling pathway protein 2
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AGTR1 angiotensin II receptor, type 1
ANOS1 anosmin 1
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BCL2A1 BCL2-related protein A1
BLCAP bladder cancer associated protein
C14ORF169 chromosome 14 open reading frame 169
CBFB core-binding factor, beta subunit
CCND1 cyclin D1
CD59 CD59 molecule, complement regulatory protein
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHIC2 cysteine-rich hydrophobic domain 2
CSNK1E casein kinase 1, epsilon
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
DACH1 dachshund family transcription factor 1
DESI2 desumoylating isopeptidase 2
DUSP14 dual specificity phosphatase 14
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAS Fas cell surface death receptor
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
HAS2 hyaluronan synthase 2
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICAM1 intercellular adhesion molecule 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ITGA6 integrin, alpha 6
JADE2 jade family PHD finger 2
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LAMC2 laminin, gamma 2
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LIF leukemia inhibitory factor
LRRC8B leucine rich repeat containing 8 family, member B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA4 melanoma antigen family A4
MALL mal, T-cell differentiation protein-like
MAP2K3 mitogen-activated protein kinase kinase 3
MAT2A methionine adenosyltransferase II, alpha
MME membrane metallo-endopeptidase
MMP3 matrix metallopeptidase 3
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDN necdin, melanoma antigen (MAGE) family member
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
OLFM4 olfactomedin 4
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PLS1 plastin 1
PNP purine nucleoside phosphorylase
PPIF peptidylprolyl isomerase F
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
PTX3 pentraxin 3, long
RPS11 ribosomal protein S11
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A10 S100 calcium binding protein A10
S100A12 S100 calcium binding protein A12
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SDC4 syndecan 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFN stratifin
SIRT3 sirtuin 3
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMAGP small cell adhesion glycoprotein
SPRR1A small proline-rich protein 1A
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TBP TATA box binding protein
TCL1A T-cell leukemia/lymphoma 1A
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TMEM185B transmembrane protein 185B
TMEM2 transmembrane protein 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)