BRD-K02708799_GSK-1059615_HME1_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

123 genes differentially expressed following the BRD-K02708799_GSK-1059615_HME1_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ANXA1 annexin A1
APOD apolipoprotein D
BANK1 B-cell scaffold protein with ankyrin repeats 1
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CASP10 caspase 10, apoptosis-related cysteine peptidase
CBR3 carbonyl reductase 3
CCNG2 cyclin G2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC2B C-type lectin domain family 2, member B
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CTH cystathionine gamma-lyase
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DEPTOR DEP domain containing MTOR-interacting protein
DHRS3 dehydrogenase/reductase (SDR family) member 3
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
ELOVL5 ELOVL fatty acid elongase 5
EPS8 epidermal growth factor receptor pathway substrate 8
EXOSC4 exosome component 4
FAM13A family with sequence similarity 13, member A
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRZB frizzled-related protein
GBP2 guanylate binding protein 2, interferon-inducible
GIMAP4 GTPase, IMAP family member 4
GPRC5B G protein-coupled receptor, class C, group 5, member B
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HIST3H2A histone cluster 3, H2a
HLA-E major histocompatibility complex, class I, E
JCHAIN joining chain of multimeric IgA and IgM
KIAA0907 KIAA0907
KLHL21 kelch-like family member 21
LGALS3 lectin, galactoside-binding, soluble, 3
LUM lumican
MAOA monoamine oxidase A
MDFIC MyoD family inhibitor domain containing
MEF2C myocyte enhancer factor 2C
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MT1F metallothionein 1F
MYBPC1 myosin binding protein C, slow type
MYO6 myosin VI
NEB nebulin
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUPR1 nuclear protein, transcriptional regulator, 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PEG10 paternally expressed 10
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFRP4 secreted frizzled-related protein 4
SLC35E2B solute carrier family 35, member E2B
SOX4 SRY (sex determining region Y)-box 4
SYNM synemin, intermediate filament protein
SYT1 synaptotagmin I
TFF1 trefoil factor 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D3 TSC22 domain family, member 3
TWIST1 twist family bHLH transcription factor 1
TXNIP thioredoxin interacting protein
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDOB aldolase B, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
CALB1 calbindin 1, 28kDa
CCND1 cyclin D1
CDC25A cell division cycle 25A
CHGB chromogranin B
CLDN10 claudin 10
CSTA cystatin A (stefin A)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DEFB1 defensin, beta 1
DICER1 dicer 1, ribonuclease type III
DUSP14 dual specificity phosphatase 14
DUSP3 dual specificity phosphatase 3
FABP6 fatty acid binding protein 6, ileal
FASTKD5 FAST kinase domains 5
FGFR3 fibroblast growth factor receptor 3
FLG filaggrin
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLIPR1 GLI pathogenesis-related 1
LAPTM4B lysosomal protein transmembrane 4 beta
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAT2A methionine adenosyltransferase II, alpha
NXT1 nuclear transport factor 2-like export factor 1
PDZK1 PDZ domain containing 1
PI3 peptidase inhibitor 3, skin-derived
PPIF peptidylprolyl isomerase F
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRO protein tyrosine phosphatase, receptor type, O
RBP4 retinol binding protein 4, plasma
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SDC4 syndecan 4
SNAP25 synaptosomal-associated protein, 25kDa
SOX11 SRY (sex determining region Y)-box 11
TBP TATA box binding protein
TEX30 testis expressed 30
TF transferrin
TIGAR TP53 induced glycolysis regulatory phosphatase
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZYX zyxin