BRD-K02708799_GSK-1059615_HME1_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K02708799_GSK-1059615_HME1_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF62 chromosome 6 open reading frame 62
CAPRIN2 caprin family member 2
CCL20 chemokine (C-C motif) ligand 20
CFD complement factor D (adipsin)
CLEC7A C-type lectin domain family 7, member A
CXCL11 chemokine (C-X-C motif) ligand 11
DIAPH2 diaphanous-related formin 2
DMD dystrophin
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EGFR epidermal growth factor receptor
EPHB2 EPH receptor B2
FAXDC2 fatty acid hydroxylase domain containing 2
FLRT2 fibronectin leucine rich transmembrane protein 2
FN1 fibronectin 1
FOXO4 forkhead box O4
GABARAPL1 GABA(A) receptor-associated protein like 1
GOLT1B golgi transport 1B
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
IL15 interleukin 15
ITGAV integrin, alpha V
JAG1 jagged 1
KLHL21 kelch-like family member 21
KYNU kynureninase
LEFTY1 left-right determination factor 1
LGALS3 lectin, galactoside-binding, soluble, 3
NOTCH2NL notch 2 N-terminal like
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDGFD platelet derived growth factor D
RNASET2 ribonuclease T2
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SNAP25 synaptosomal-associated protein, 25kDa
SOX4 SRY (sex determining region Y)-box 4
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STMN2 stathmin 2
SYT1 synaptotagmin I
TLR4 toll-like receptor 4
TRIM22 tripartite motif containing 22
VNN1 vanin 1
VPS13B vacuolar protein sorting 13 homolog B (yeast)
VTCN1 V-set domain containing T cell activation inhibitor 1
XK X-linked Kx blood group
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
BIRC5 baculoviral IAP repeat containing 5
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C1QBP complement component 1, q subcomponent binding protein
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CNN3 calponin 3, acidic
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
ELAVL1 ELAV like RNA binding protein 1
ENO1 enolase 1, (alpha)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRIA2 glutamate receptor, ionotropic, AMPA 2
HACD3 3-hydroxyacyl-CoA dehydratase 3
HIST1H4C histone cluster 1, H4c
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPB1 heat shock 27kDa protein 1
KIAA0101 KIAA0101
KRT19 keratin 19, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MALL mal, T-cell differentiation protein-like
MCM5 minichromosome maintenance complex component 5
MRPL12 mitochondrial ribosomal protein L12
MYCBP MYC binding protein
NME1 NME/NM23 nucleoside diphosphate kinase 1
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RANBP1 RAN binding protein 1
RBBP8 retinoblastoma binding protein 8
RPA3 replication protein A3, 14kDa
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SFN stratifin
SFTPB surfactant protein B
SFTPD surfactant protein D
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLIRP SRA stem-loop interacting RNA binding protein
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
STMN1 stathmin 1
TSPAN13 tetraspanin 13
TSPAN3 tetraspanin 3
TXN thioredoxin
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
ZWINT ZW10 interacting kinetochore protein