BRD-K02708799_GSK-1059615_HME1_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K02708799_GSK-1059615_HME1_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
CADM1 cell adhesion molecule 1
CCDC92 coiled-coil domain containing 92
CD44 CD44 molecule (Indian blood group)
CFD complement factor D (adipsin)
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CRABP1 cellular retinoic acid binding protein 1
CTSB cathepsin B
EPHA3 EPH receptor A3
FCGBP Fc fragment of IgG binding protein
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
GALC galactosylceramidase
GLUL glutamate-ammonia ligase
GPR137B G protein-coupled receptor 137B
IFITM1 interferon induced transmembrane protein 1
IGKC immunoglobulin kappa constant
IL1B interleukin 1, beta
ITGAV integrin, alpha V
ITM2A integral membrane protein 2A
JAG1 jagged 1
LBH limb bud and heart development
LGALS3 lectin, galactoside-binding, soluble, 3
MAP1B microtubule-associated protein 1B
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXRA5 matrix-remodelling associated 5
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OLFM4 olfactomedin 4
PCP4 Purkinje cell protein 4
PECR peroxisomal trans-2-enoyl-CoA reductase
PLAGL1 pleiomorphic adenoma gene-like 1
PTCH1 patched 1
QPCT glutaminyl-peptide cyclotransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REG1A regenerating islet-derived 1 alpha
REG1B regenerating islet-derived 1 beta
REG3A regenerating islet-derived 3 alpha
SEC31A SEC31 homolog A (S. cerevisiae)
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SH3BGRL SH3 domain binding glutamate-rich protein like
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TUBA1A tubulin, alpha 1a

decreased expression

Symbol Name
BIRC5 baculoviral IAP repeat containing 5
C1QBP complement component 1, q subcomponent binding protein
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CD36 CD36 molecule (thrombospondin receptor)
CDK1 cyclin-dependent kinase 1
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
ELAVL1 ELAV like RNA binding protein 1
GATA3 GATA binding protein 3
HIST1H4C histone cluster 1, H4c
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD2 interferon-related developmental regulator 2
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAP7 microtubule-associated protein 7
MRPS30 mitochondrial ribosomal protein S30
NPY1R neuropeptide Y receptor Y1
PLK1 polo-like kinase 1
RPA3 replication protein A3, 14kDa
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TPX2 TPX2, microtubule-associated
UBE2S ubiquitin-conjugating enzyme E2S