BRD-K02708799_GSK-1059615_HEPG2_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K02708799_GSK-1059615_HEPG2_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AHNAK2 AHNAK nucleoprotein 2
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANG angiogenin, ribonuclease, RNase A family, 5
ANKRD36B ankyrin repeat domain 36B
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
CCNG2 cyclin G2
CD44 CD44 molecule (Indian blood group)
CRISP3 cysteine-rich secretory protein 3
CRYAB crystallin, alpha B
CST1 cystatin SN
CTSD cathepsin D
CXCL5 chemokine (C-X-C motif) ligand 5
CYFIP2 cytoplasmic FMR1 interacting protein 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DPYSL2 dihydropyrimidinase-like 2
DST dystonin
ERBB3 erb-b2 receptor tyrosine kinase 3
FGFR3 fibroblast growth factor receptor 3
FOXN3 forkhead box N3
FXYD2 FXYD domain containing ion transport regulator 2
GAS1 growth arrest-specific 1
GNB5 guanine nucleotide binding protein (G protein), beta 5
HDAC6 histone deacetylase 6
HIST1H2AC histone cluster 1, H2ac
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMCD1 LIM and cysteine-rich domains 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MDK midkine (neurite growth-promoting factor 2)
MYH10 myosin, heavy chain 10, non-muscle
MYO6 myosin VI
NEFL neurofilament, light polypeptide
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NR1D2 nuclear receptor subfamily 1, group D, member 2
OSBPL8 oxysterol binding protein-like 8
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDGFC platelet derived growth factor C
PDZK1IP1 PDZK1 interacting protein 1
PKP4 plakophilin 4
PNMA2 paraneoplastic Ma antigen 2
PON3 paraoxonase 3
PYGL phosphorylase, glycogen, liver
RBKS ribokinase
RBP4 retinol binding protein 4, plasma
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RHOBTB1 Rho-related BTB domain containing 1
RNASE4 ribonuclease, RNase A family, 4
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TBC1D4 TBC1 domain family, member 4
TM4SF1 transmembrane 4 L six family member 1
TNS3 tensin 3
TSPAN8 tetraspanin 8
TWF2 twinfilin actin binding protein 2
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZBTB18 zinc finger and BTB domain containing 18
ZIC1 Zic family member 1
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDOA aldolase A, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CCNE2 cyclin E2
CD53 CD53 molecule
CDC42 cell division cycle 42
COL1A2 collagen, type I, alpha 2
COL4A6 collagen, type IV, alpha 6
CXCL9 chemokine (C-X-C motif) ligand 9
DHRS2 dehydrogenase/reductase (SDR family) member 2
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FAM162A family with sequence similarity 162, member A
FTH1 ferritin, heavy polypeptide 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GCLM glutamate-cysteine ligase, modifier subunit
GJA1 gap junction protein, alpha 1, 43kDa
GLIPR1 GLI pathogenesis-related 1
GPI glucose-6-phosphate isomerase
GRWD1 glutamate-rich WD repeat containing 1
HOPX HOP homeobox
HSPB8 heat shock 22kDa protein 8
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
JCHAIN joining chain of multimeric IgA and IgM
KLK11 kallikrein-related peptidase 11
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LAMA4 laminin, alpha 4
LAPTM5 lysosomal protein transmembrane 5
LYN LYN proto-oncogene, Src family tyrosine kinase
MBOAT7 membrane bound O-acyltransferase domain containing 7
MECOM MDS1 and EVI1 complex locus
MRPS2 mitochondrial ribosomal protein S2
MT1F metallothionein 1F
NPM3 nucleophosmin/nucleoplasmin 3
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PEX11A peroxisomal biogenesis factor 11 alpha
PGAM1 phosphoglycerate mutase 1 (brain)
PLAC8 placenta-specific 8
PLIN2 perilipin 2
PMM2 phosphomannomutase 2
PRPF4 pre-mRNA processing factor 4
PTHLH parathyroid hormone-like hormone
RAD23B RAD23 homolog B (S. cerevisiae)
RAD51C RAD51 paralog C
RGS5 regulator of G-protein signaling 5
S100A10 S100 calcium binding protein A10
SERHL2 serine hydrolase-like 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLPI secretory leukocyte peptidase inhibitor
STK17A serine/threonine kinase 17a
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFRC transferrin receptor
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPPP3 tubulin polymerization-promoting protein family member 3
UGCG UDP-glucose ceramide glucosyltransferase