BRD-K02708799_GSK-1059615_HEPG2_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

78 genes differentially expressed following the BRD-K02708799_GSK-1059615_HEPG2_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
BMP4 bone morphogenetic protein 4
COL11A1 collagen, type XI, alpha 1
CYBA cytochrome b-245, alpha polypeptide
ENO2 enolase 2 (gamma, neuronal)
ERBB3 erb-b2 receptor tyrosine kinase 3
FBN2 fibrillin 2
GJA1 gap junction protein, alpha 1, 43kDa
H1FX H1 histone family, member X
HBB hemoglobin, beta
IRS2 insulin receptor substrate 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LOX lysyl oxidase
LTBP3 latent transforming growth factor beta binding protein 3
MDK midkine (neurite growth-promoting factor 2)
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PROM1 prominin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SORBS3 sorbin and SH3 domain containing 3
STXBP1 syntaxin binding protein 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNS3 tensin 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ARL4A ADP-ribosylation factor-like 4A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BLNK B-cell linker
C7 complement component 7
CALD1 caldesmon 1
CCND2 cyclin D2
COL14A1 collagen, type XIV, alpha 1
COL4A6 collagen, type IV, alpha 6
CPM carboxypeptidase M
CSTA cystatin A (stefin A)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
GATA6 GATA binding protein 6
GREB1 growth regulation by estrogen in breast cancer 1
GSTT1 glutathione S-transferase theta 1
HIST1H2BG histone cluster 1, H2bg
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPB8 heat shock 22kDa protein 8
IGF1 insulin-like growth factor 1 (somatomedin C)
IGHM immunoglobulin heavy constant mu
JCHAIN joining chain of multimeric IgA and IgM
KRT15 keratin 15, type I
MAP2K3 mitogen-activated protein kinase kinase 3
MCAM melanoma cell adhesion molecule
MSMB microseminoprotein, beta-
MT1E metallothionein 1E
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
NKX3-1 NK3 homeobox 1
OLFM4 olfactomedin 4
PAK1IP1 PAK1 interacting protein 1
PALLD palladin, cytoskeletal associated protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAD51C RAD51 paralog C
SCAF11 SR-related CTD-associated factor 11
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SELENBP1 selenium binding protein 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SPDEF SAM pointed domain containing ETS transcription factor
SPINK1 serine peptidase inhibitor, Kazal type 1
SPTSSA serine palmitoyltransferase, small subunit A
STK17A serine/threonine kinase 17a
TFF3 trefoil factor 3 (intestinal)