BRD-K02708799_GSK-1059615_HCC515_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

70 genes differentially expressed following the BRD-K02708799_GSK-1059615_HCC515_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG2 adhesion G protein-coupled receptor G2
AHR aryl hydrocarbon receptor
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAD BCL2-associated agonist of cell death
C1RL complement component 1, r subcomponent-like
CFH complement factor H
DMD dystrophin
EIF5A eukaryotic translation initiation factor 5A
FKBP1B FK506 binding protein 1B, 12.6 kDa
IFI6 interferon, alpha-inducible protein 6
IGFBP7 insulin-like growth factor binding protein 7
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JAG1 jagged 1
LEPR leptin receptor
LXN latexin
LYZ lysozyme
MFAP5 microfibrillar associated protein 5
NLRP2 NLR family, pyrin domain containing 2
NPEPL1 aminopeptidase-like 1
PEG10 paternally expressed 10
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAC8 placenta-specific 8
PLS3 plastin 3
PROS1 protein S (alpha)
RAB4A RAB4A, member RAS oncogene family
RABGAP1L RAB GTPase activating protein 1-like
RNASET2 ribonuclease T2
SCG2 secretogranin II
SLPI secretory leukocyte peptidase inhibitor
SORBS3 sorbin and SH3 domain containing 3
SOX4 SRY (sex determining region Y)-box 4
STAT1 signal transducer and activator of transcription 1, 91kDa
TIMP3 TIMP metallopeptidase inhibitor 3
VAMP8 vesicle-associated membrane protein 8

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALOX5 arachidonate 5-lipoxygenase
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
CLCA1 chloride channel accessory 1
CLDN3 claudin 3
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DEFA5 defensin, alpha 5, Paneth cell-specific
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FGF13 fibroblast growth factor 13
IDI1 isopentenyl-diphosphate delta isomerase 1
IER5 immediate early response 5
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
IPO13 importin 13
KRT20 keratin 20, type I
LTF lactotransferrin
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
NAMPT nicotinamide phosphoribosyltransferase
NDP Norrie disease (pseudoglioma)
OLFM4 olfactomedin 4
PDZRN3 PDZ domain containing ring finger 3
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SPON1 spondin 1, extracellular matrix protein
STC1 stanniocalcin 1
TBX3 T-box 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNIP1 TNFAIP3 interacting protein 1
TPSAB1 tryptase alpha/beta 1
VCAN versican