BRD-K02708799_GSK-1059615_HA1E_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

432 genes differentially expressed following the BRD-K02708799_GSK-1059615_HA1E_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABHD4 abhydrolase domain containing 4
ACTA1 actin, alpha 1, skeletal muscle
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAM10 ADAM metallopeptidase domain 10
ADCK3 aarF domain containing kinase 3
ADGRG6 adhesion G protein-coupled receptor G6
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
AMOTL2 angiomotin like 2
ANGPT1 angiopoietin 1
ANO1 anoctamin 1, calcium activated chloride channel
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
APOE apolipoprotein E
AREG amphiregulin
ARID5B AT rich interactive domain 5B (MRF1-like)
ASPN asporin
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP9A ATPase, class II, type 9A
BCL6 B-cell CLL/lymphoma 6
BGN biglycan
C10ORF10 chromosome 10 open reading frame 10
C1ORF115 chromosome 1 open reading frame 115
C2CD5 C2 calcium-dependent domain containing 5
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAMLG calcium modulating ligand
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CD99 CD99 molecule
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN8 claudin 8
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL10A1 collagen, type X, alpha 1
COL5A2 collagen, type V, alpha 2
COL8A2 collagen, type VIII, alpha 2
COMP cartilage oligomeric matrix protein
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTSK cathepsin K
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DAPK1 death-associated protein kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMD dystrophin
DPYD dihydropyrimidine dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
ECM1 extracellular matrix protein 1
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ELN elastin
ETV1 ets variant 1
EZR ezrin
F2R coagulation factor II (thrombin) receptor
FAM129A family with sequence similarity 129, member A
FBLN1 fibulin 1
FOXN3 forkhead box N3
FRY furry homolog (Drosophila)
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GDF15 growth differentiation factor 15
GLUL glutamate-ammonia ligase
GNB5 guanine nucleotide binding protein (G protein), beta 5
GNLY granulysin
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPC3 glypican 3
GREM1 gremlin 1, DAN family BMP antagonist
GSN gelsolin
H1F0 H1 histone family, member 0
H1FX H1 histone family, member X
HCAR3 hydroxycarboxylic acid receptor 3
HDAC6 histone deacetylase 6
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H4C histone cluster 1, H4c
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HNMT histamine N-methyltransferase
HOPX HOP homeobox
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IFRD2 interferon-related developmental regulator 2
INHBA inhibin, beta A
INSR insulin receptor
IQGAP1 IQ motif containing GTPase activating protein 1
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JADE2 jade family PHD finger 2
JUP junction plakoglobin
KANK2 KN motif and ankyrin repeat domains 2
KAT6A K(lysine) acetyltransferase 6A
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KDM5D lysine (K)-specific demethylase 5D
KLF10 Kruppel-like factor 10
KRT14 keratin 14, type I
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LHX2 LIM homeobox 2
LIG1 ligase I, DNA, ATP-dependent
LIMK2 LIM domain kinase 2
LIMS1 LIM and senescent cell antigen-like domains 1
LOC100272216 uncharacterized LOC100272216
LXN latexin
MACF1 microtubule-actin crosslinking factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGED1 melanoma antigen family D1
MAPK13 mitogen-activated protein kinase 13
MARCKSL1 MARCKS-like 1
MB myoglobin
MEIS2 Meis homeobox 2
MFAP2 microfibrillar-associated protein 2
MMP11 matrix metallopeptidase 11
MMP9 matrix metallopeptidase 9
MN1 meningioma (disrupted in balanced translocation) 1
MT1E metallothionein 1E
MTSS1 metastasis suppressor 1
MXRA7 matrix-remodelling associated 7
MYO5C myosin VC
NELL2 NEL-like 2 (chicken)
NFIB nuclear factor I/B
NID1 nidogen 1
NOTCH1 notch 1
NOX4 NADPH oxidase 4
NPTX2 neuronal pentraxin II
NR1H3 nuclear receptor subfamily 1, group H, member 3
NXN nucleoredoxin
OLFM1 olfactomedin 1
PALLD palladin, cytoskeletal associated protein
PALMD palmdelphin
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM5 PDZ and LIM domain 5
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLSCR4 phospholipid scramblase 4
PLXND1 plexin D1
PNKP polynucleotide kinase 3'-phosphatase
POSTN periostin, osteoblast specific factor
PPAP2C phosphatidic acid phosphatase type 2C
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PROM1 prominin 1
PSIP1 PC4 and SFRS1 interacting protein 1
RBM6 RNA binding motif protein 6
RNASE4 ribonuclease, RNase A family, 4
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS27L ribosomal protein S27-like
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RTN1 reticulon 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP4 secreted frizzled-related protein 4
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
STON1 stonin 1
SULF1 sulfatase 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYNE2 spectrin repeat containing, nuclear envelope 2
TCAF1 TRPM8 channel-associated factor 1
TCF4 transcription factor 4
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI2 tissue factor pathway inhibitor 2
TGIF1 TGFB-induced factor homeobox 1
THBS1 thrombospondin 1
THBS4 thrombospondin 4
TIMP3 TIMP metallopeptidase inhibitor 3
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TPM2 tropomyosin 2 (beta)
TSPAN13 tetraspanin 13
TXNIP thioredoxin interacting protein
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican
VDAC1 voltage-dependent anion channel 1
VNN1 vanin 1
WDTC1 WD and tetratricopeptide repeats 1
WEE1 WEE1 G2 checkpoint kinase
XIST X inactive specific transcript (non-protein coding)
YBX3 Y box binding protein 3
YME1L1 YME1-like 1 ATPase
ZBTB18 zinc finger and BTB domain containing 18
ZNF331 zinc finger protein 331
ZNF423 zinc finger protein 423
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AK4 adenylate kinase 4
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
ASRGL1 asparaginase like 1
BASP1 brain abundant, membrane attached signal protein 1
BCHE butyrylcholinesterase
BIK BCL2-interacting killer (apoptosis-inducing)
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C3ORF14 chromosome 3 open reading frame 14
C7 complement component 7
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CALB1 calbindin 1, 28kDa
CAST calpastatin
CBS cystathionine-beta-synthase
CCDC86 coiled-coil domain containing 86
CCND1 cyclin D1
CCND2 cyclin D2
CD163 CD163 molecule
CD24 CD24 molecule
CD320 CD320 molecule
CD47 CD47 molecule
CD58 CD58 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEMIP cell migration inducing protein, hyaluronan binding
CFD complement factor D (adipsin)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CKB creatine kinase, brain
CLU clusterin
COL9A3 collagen, type IX, alpha 3
CPA3 carboxypeptidase A3 (mast cell)
CPVL carboxypeptidase, vitellogenic-like
CREB1 cAMP responsive element binding protein 1
CRYAB crystallin, alpha B
CTSC cathepsin C
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYTL1 cytokine-like 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DMTF1 cyclin D binding myb-like transcription factor 1
EIF5 eukaryotic translation initiation factor 5
ENO1 enolase 1, (alpha)
EPHA3 EPH receptor A3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS2 fatty acid desaturase 2
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM107A family with sequence similarity 107, member A
FAM162A family with sequence similarity 162, member A
FASN fatty acid synthase
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCGBP Fc fragment of IgG binding protein
FGF13 fibroblast growth factor 13
FGFR2 fibroblast growth factor receptor 2
FKBP4 FK506 binding protein 4, 59kDa
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPI glucose-6-phosphate isomerase
GPM6B glycoprotein M6B
GPX3 glutathione peroxidase 3
GRB7 growth factor receptor-bound protein 7
GSPT1 G1 to S phase transition 1
GSTM3 glutathione S-transferase mu 3 (brain)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HBD hemoglobin, delta
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2AC histone cluster 1, H2ac
HK1 hexokinase 1
HK2 hexokinase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IFRD1 interferon-related developmental regulator 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGKC immunoglobulin kappa constant
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KRT4 keratin 4, type II
KRT6A keratin 6A, type II
L1CAM L1 cell adhesion molecule
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LOC100505650 uncharacterized LOC100505650
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC17 leucine rich repeat containing 17
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LTF lactotransferrin
MAL mal, T-cell differentiation protein
MATN2 matrilin 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP4 microfibrillar-associated protein 4
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAV3 neuron navigator 3
NDRG1 N-myc downstream regulated 1
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NID2 nidogen 2 (osteonidogen)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPL1 nucleoporin like 1
OAT ornithine aminotransferase
ODC1 ornithine decarboxylase 1
OLFM4 olfactomedin 4
OPN3 opsin 3
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PAK1IP1 PAK1 interacting protein 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PAX8 paired box 8
PCDH9 protocadherin 9
PCOLCE2 procollagen C-endopeptidase enhancer 2
PCP4 Purkinje cell protein 4
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PEA15 phosphoprotein enriched in astrocytes 15
PFKP phosphofructokinase, platelet
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PKM pyruvate kinase, muscle
PLAT plasminogen activator, tissue
PNP purine nucleoside phosphorylase
PPAP2B phosphatidic acid phosphatase type 2B
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPIF peptidylprolyl isomerase F
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRDX4 peroxiredoxin 4
PRPF4 pre-mRNA processing factor 4
PRSS2 protease, serine, 2 (trypsin 2)
PSAT1 phosphoserine aminotransferase 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTDSS1 phosphatidylserine synthase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
QPRT quinolinate phosphoribosyltransferase
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RHOBTB3 Rho-related BTB domain containing 3
RND3 Rho family GTPase 3
RPL37A ribosomal protein L37a
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGD Ras-related GTP binding D
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100A9 S100 calcium binding protein A9
S100B S100 calcium binding protein B
SC5D sterol-C5-desaturase
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCML1 sex comb on midleg-like 1 (Drosophila)
SCRG1 stimulator of chondrogenesis 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
SPAG4 sperm associated antigen 4
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRGN serglycin
SRPX sushi-repeat containing protein, X-linked
STC1 stanniocalcin 1
STC2 stanniocalcin 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUB1 SUB1 homolog (S. cerevisiae)
TAGLN2 transgelin 2
TCF21 transcription factor 21
TCTN1 tectonic family member 1
TFRC transferrin receptor
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TM4SF1 transmembrane 4 L six family member 1
TMED5 transmembrane emp24 protein transport domain containing 5
TNC tenascin C
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TOMM34 translocase of outer mitochondrial membrane 34
TOR1A torsin family 1, member A (torsin A)
TXNDC9 thioredoxin domain containing 9
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UXS1 UDP-glucuronate decarboxylase 1
VCAM1 vascular cell adhesion molecule 1
YAP1 Yes-associated protein 1
YARS tyrosyl-tRNA synthetase
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBED2 zinc finger, BED-type containing 2
ZMYM2 zinc finger, MYM-type 2
ZNF274 zinc finger protein 274