BRD-K02708799_GSK-1059615_HA1E_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

284 genes differentially expressed following the BRD-K02708799_GSK-1059615_HA1E_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADGRG6 adhesion G protein-coupled receptor G6
ADIPOQ adiponectin, C1Q and collagen domain containing
AHNAK2 AHNAK nucleoprotein 2
AHR aryl hydrocarbon receptor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
AQP3 aquaporin 3 (Gill blood group)
ARHGAP32 Rho GTPase activating protein 32
ASPN asporin
ATP9A ATPase, class II, type 9A
BCL3 B-cell CLL/lymphoma 3
BGN biglycan
C10ORF10 chromosome 10 open reading frame 10
C2CD5 C2 calcium-dependent domain containing 5
C8ORF4 chromosome 8 open reading frame 4
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCNB1 cyclin B1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLEC2B C-type lectin domain family 2, member B
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL15A1 collagen, type XV, alpha 1
COL5A2 collagen, type V, alpha 2
COL8A2 collagen, type VIII, alpha 2
COMP cartilage oligomeric matrix protein
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSNK1A1 casein kinase 1, alpha 1
CXADR coxsackie virus and adenovirus receptor
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
ETV1 ets variant 1
F2R coagulation factor II (thrombin) receptor
FABP4 fatty acid binding protein 4, adipocyte
FAP fibroblast activation protein, alpha
FBLN1 fibulin 1
FBN2 fibrillin 2
GALC galactosylceramidase
GAS1 growth arrest-specific 1
GAS6 growth arrest-specific 6
GDF15 growth differentiation factor 15
GNLY granulysin
GREM1 gremlin 1, DAN family BMP antagonist
GSN gelsolin
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HDAC6 histone deacetylase 6
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HOXA5 homeobox A5
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA2 heat shock 70kDa protein 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
INHBA inhibin, beta A
INSM1 insulinoma-associated 1
IQGAP1 IQ motif containing GTPase activating protein 1
IRS2 insulin receptor substrate 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KRT7 keratin 7, type II
LIG1 ligase I, DNA, ATP-dependent
LIMS1 LIM and senescent cell antigen-like domains 1
LRRC15 leucine rich repeat containing 15
LXN latexin
MARCKS myristoylated alanine-rich protein kinase C substrate
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MFAP2 microfibrillar-associated protein 2
MMP11 matrix metallopeptidase 11
MXRA5 matrix-remodelling associated 5
MYO6 myosin VI
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLFM1 olfactomedin 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PBX1 pre-B-cell leukemia homeobox 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PDPN podoplanin
PECR peroxisomal trans-2-enoyl-CoA reductase
PERP PERP, TP53 apoptosis effector
PHIP pleckstrin homology domain interacting protein
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PIP prolactin-induced protein
PLSCR3 phospholipid scramblase 3
PLXNC1 plexin C1
PON3 paraoxonase 3
POSTN periostin, osteoblast specific factor
PPIC peptidylprolyl isomerase C (cyclophilin C)
RBP1 retinol binding protein 1, cellular
RGS5 regulator of G-protein signaling 5
RHOBTB3 Rho-related BTB domain containing 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SIK1 salt-inducible kinase 1
SOCS2 suppressor of cytokine signaling 2
SOX4 SRY (sex determining region Y)-box 4
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPRED2 sprouty-related, EVH1 domain containing 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAT4 signal transducer and activator of transcription 4
STON1 stonin 1
SULF1 sulfatase 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TTC3 tetratricopeptide repeat domain 3
WASF3 WAS protein family, member 3
WDTC1 WD and tetratricopeptide repeats 1
XIST X inactive specific transcript (non-protein coding)
YBX3 Y box binding protein 3
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACOT9 acyl-CoA thioesterase 9
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ANK2 ankyrin 2, neuronal
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BASP1 brain abundant, membrane attached signal protein 1
BCHE butyrylcholinesterase
BIN1 bridging integrator 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C7 complement component 7
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CAPN6 calpain 6
CCDC86 coiled-coil domain containing 86
CCND2 cyclin D2
CD24 CD24 molecule
CD47 CD47 molecule
CD58 CD58 molecule
CFD complement factor D (adipsin)
CHPT1 choline phosphotransferase 1
CHRDL1 chordin-like 1
CKAP4 cytoskeleton-associated protein 4
CLU clusterin
COL9A3 collagen, type IX, alpha 3
CORO1C coronin, actin binding protein, 1C
COX11 COX11 cytochrome c oxidase copper chaperone
CRYAB crystallin, alpha B
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYTL1 cytokine-like 1
DDIT4 DNA-damage-inducible transcript 4
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EAF2 ELL associated factor 2
EDNRB endothelin receptor type B
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ENG endoglin
EPHA3 EPH receptor A3
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FAM162A family with sequence similarity 162, member A
FCGBP Fc fragment of IgG binding protein
FOXF1 forkhead box F1
G0S2 G0/G1 switch 2
GEM GTP binding protein overexpressed in skeletal muscle
GPI glucose-6-phosphate isomerase
GPX3 glutathione peroxidase 3
GYG1 glycogenin 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HILPDA hypoxia inducible lipid droplet-associated
HK1 hexokinase 1
HK2 hexokinase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGL immunoglobulin lambda locus
IL1R2 interleukin 1 receptor, type II
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KRT15 keratin 15, type I
LCN2 lipocalin 2
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LEF1 lymphoid enhancer-binding factor 1
LMO4 LIM domain only 4
LOC100505650 uncharacterized LOC100505650
LOX lysyl oxidase
LPIN1 lipin 1
LTF lactotransferrin
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MATN2 matrilin 2
MFAP4 microfibrillar-associated protein 4
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NID2 nidogen 2 (osteonidogen)
NPR3 natriuretic peptide receptor 3
NRCAM neuronal cell adhesion molecule
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
ODC1 ornithine decarboxylase 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PAPD7 PAP associated domain containing 7
PAX8 paired box 8
PCCB propionyl CoA carboxylase, beta polypeptide
PCDH9 protocadherin 9
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDAP1 PDGFA associated protein 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEA15 phosphoprotein enriched in astrocytes 15
PFKP phosphofructokinase, platelet
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PKM pyruvate kinase, muscle
PNP purine nucleoside phosphorylase
PPAP2B phosphatidic acid phosphatase type 2B
PPL periplakin
PROM1 prominin 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PTGDS prostaglandin D2 synthase 21kDa (brain)
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RNASET2 ribonuclease T2
S100A6 S100 calcium binding protein A6
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAP30 Sin3A-associated protein, 30kDa
SCGB2A2 secretoglobin, family 2A, member 2
SCRG1 stimulator of chondrogenesis 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMS spermine synthase
SMYD2 SET and MYND domain containing 2
SORBS2 sorbin and SH3 domain containing 2
SPAG4 sperm associated antigen 4
SRGN serglycin
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TACSTD2 tumor-associated calcium signal transducer 2
TF transferrin
TFRC transferrin receptor
TM4SF1 transmembrane 4 L six family member 1
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
ZMYM2 zinc finger, MYM-type 2
ZNF131 zinc finger protein 131
ZNF22 zinc finger protein 22
ZNF274 zinc finger protein 274