BRD-K02708799_GSK-1059615_HA1E_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

268 genes differentially expressed following the BRD-K02708799_GSK-1059615_HA1E_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABHD4 abhydrolase domain containing 4
ADCY9 adenylate cyclase 9
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ASPN asporin
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C2CD5 C2 calcium-dependent domain containing 5
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL20 chemokine (C-C motif) ligand 20
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL5A2 collagen, type V, alpha 2
COL8A2 collagen, type VIII, alpha 2
CRELD2 cysteine-rich with EGF-like domains 2
CRISP3 cysteine-rich secretory protein 3
CX3CL1 chemokine (C-X3-C motif) ligand 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DKK1 dickkopf WNT signaling pathway inhibitor 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDN1 endothelin 1
EGR1 early growth response 1
EGR3 early growth response 3
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EMP1 epithelial membrane protein 1
FBLN1 fibulin 1
FOXJ3 forkhead box J3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GALC galactosylceramidase
GDF15 growth differentiation factor 15
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNB5 guanine nucleotide binding protein (G protein), beta 5
GNLY granulysin
GRAMD1C GRAM domain containing 1C
GREM1 gremlin 1, DAN family BMP antagonist
HIST1H4C histone cluster 1, H4c
HOXA10 homeobox A10
HSPA2 heat shock 70kDa protein 2
IER2 immediate early response 2
INHBA inhibin, beta A
INSR insulin receptor
IQGAP1 IQ motif containing GTPase activating protein 1
ISLR immunoglobulin superfamily containing leucine-rich repeat
ITGB5 integrin, beta 5
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KIAA0226L KIAA0226-like
KLF10 Kruppel-like factor 10
KRT19 keratin 19, type I
LIMCH1 LIM and calponin homology domains 1
LIMS1 LIM and senescent cell antigen-like domains 1
LITAF lipopolysaccharide-induced TNF factor
LMCD1 LIM and cysteine-rich domains 1
LXN latexin
MANSC1 MANSC domain containing 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MBP myelin basic protein
MEF2C myocyte enhancer factor 2C
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP11 matrix metallopeptidase 11
MT1E metallothionein 1E
MT1F metallothionein 1F
MTSS1 metastasis suppressor 1
NCALD neurocalcin delta
OLFML2A olfactomedin-like 2A
PADI2 peptidyl arginine deiminase, type II
PDGFD platelet derived growth factor D
PHACTR2 phosphatase and actin regulator 2
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PLAC8 placenta-specific 8
PLCL1 phospholipase C-like 1
PLXNB2 plexin B2
POSTN periostin, osteoblast specific factor
PPIC peptidylprolyl isomerase C (cyclophilin C)
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
QARS glutaminyl-tRNA synthetase
RABGAP1L RAB GTPase activating protein 1-like
RAP1GAP2 RAP1 GTPase activating protein 2
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN2 reticulon 2
SCG5 secretogranin V
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SFRP4 secreted frizzled-related protein 4
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SOCS2 suppressor of cytokine signaling 2
SON SON DNA binding protein
STAG2 stromal antigen 2
STK38L serine/threonine kinase 38 like
STON1 stonin 1
SULF1 sulfatase 1
SYNE2 spectrin repeat containing, nuclear envelope 2
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMC5 transmembrane channel-like 5
TMPO thymopoietin
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM22 tripartite motif containing 22
TSPAN8 tetraspanin 8
TTC3 tetratricopeptide repeat domain 3
TXNIP thioredoxin interacting protein
VASH1 vasohibin 1
WDR13 WD repeat domain 13
WDTC1 WD and tetratricopeptide repeats 1
WNK1 WNK lysine deficient protein kinase 1
XIST X inactive specific transcript (non-protein coding)
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AK4 adenylate kinase 4
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
AOX1 aldehyde oxidase 1
ARHGAP29 Rho GTPase activating protein 29
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
AUTS2 autism susceptibility candidate 2
BCHE butyrylcholinesterase
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BZW2 basic leucine zipper and W2 domains 2
C3 complement component 3
C7 complement component 7
CA1 carbonic anhydrase I
CA9 carbonic anhydrase IX
CBS cystathionine-beta-synthase
CCDC86 coiled-coil domain containing 86
CCL17 chemokine (C-C motif) ligand 17
CCND2 cyclin D2
CD36 CD36 molecule (thrombospondin receptor)
CD47 CD47 molecule
CHN2 chimerin 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLU clusterin
COL6A2 collagen, type VI, alpha 2
COL9A3 collagen, type IX, alpha 3
COX11 COX11 cytochrome c oxidase copper chaperone
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5A cytochrome b5 type A (microsomal)
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYTL1 cytokine-like 1
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DMTF1 cyclin D binding myb-like transcription factor 1
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5 eukaryotic translation initiation factor 5
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
EPHA3 EPH receptor A3
ESR1 estrogen receptor 1
FABP4 fatty acid binding protein 4, adipocyte
FAM162A family with sequence similarity 162, member A
FASTKD3 FAST kinase domains 3
GLDC glycine dehydrogenase (decarboxylating)
GPI glucose-6-phosphate isomerase
GPX3 glutathione peroxidase 3
GUK1 guanylate kinase 1
GYG1 glycogenin 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
JMJD6 jumonji domain containing 6
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KDM5D lysine (K)-specific demethylase 5D
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KLF4 Kruppel-like factor 4 (gut)
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KLK6 kallikrein-related peptidase 6
KRT13 keratin 13, type I
L1CAM L1 cell adhesion molecule
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMO4 LIM domain only 4
LOC100505650 uncharacterized LOC100505650
LPIN1 lipin 1
LTF lactotransferrin
LUM lumican
MAN1A1 mannosidase, alpha, class 1A, member 1
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MREG melanoregulin
MRPL12 mitochondrial ribosomal protein L12
MRPL19 mitochondrial ribosomal protein L19
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MSMO1 methylsterol monooxygenase 1
MUC16 mucin 16, cell surface associated
MUC4 mucin 4, cell surface associated
NME1 NME/NM23 nucleoside diphosphate kinase 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NRN1 neuritin 1
ODC1 ornithine decarboxylase 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAX8 paired box 8
PDHX pyruvate dehydrogenase complex, component X
PFKP phosphofructokinase, platelet
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PKM pyruvate kinase, muscle
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PLTP phospholipid transfer protein
PMP22 peripheral myelin protein 22
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPA1 pyrophosphatase (inorganic) 1
PPAP2B phosphatidic acid phosphatase type 2B
PRKCA protein kinase C, alpha
PRSS2 protease, serine, 2 (trypsin 2)
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
REG3A regenerating islet-derived 3 alpha
RHOB ras homolog family member B
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCML1 sex comb on midleg-like 1 (Drosophila)
SCRG1 stimulator of chondrogenesis 1
SKP1 S-phase kinase-associated protein 1
SPAG4 sperm associated antigen 4
SRGN serglycin
SST somatostatin
TARS threonyl-tRNA synthetase
TFF3 trefoil factor 3 (intestinal)
TFRC transferrin receptor
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TMEM100 transmembrane protein 100
TMEM176B transmembrane protein 176B
TMEM47 transmembrane protein 47
TSPAN13 tetraspanin 13
TWF1 twinfilin actin binding protein 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VSIG4 V-set and immunoglobulin domain containing 4
WDR61 WD repeat domain 61
ZIC1 Zic family member 1
ZNF185 zinc finger protein 185 (LIM domain)
ZW10 zw10 kinetochore protein