BRD-K02708799_GSK-1059615_BT20_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K02708799_GSK-1059615_BT20_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
APOD apolipoprotein D
APOE apolipoprotein E
ARG1 arginase 1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BLNK B-cell linker
C1S complement component 1, s subcomponent
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL20 chemokine (C-C motif) ligand 20
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL5 chemokine (C-X-C motif) ligand 5
DPP4 dipeptidyl-peptidase 4
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
FAM129A family with sequence similarity 129, member A
GAS1 growth arrest-specific 1
GBP2 guanylate binding protein 2, interferon-inducible
GLUL glutamate-ammonia ligase
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
HP haptoglobin
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1R1 interleukin 1 receptor, type I
JUND jun D proto-oncogene
KIAA0907 KIAA0907
LAMP5 lysosomal-associated membrane protein family, member 5
LEF1 lymphoid enhancer-binding factor 1
LGALS3 lectin, galactoside-binding, soluble, 3
LRRC17 leucine rich repeat containing 17
MAN1A1 mannosidase, alpha, class 1A, member 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PEG10 paternally expressed 10
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRTN3 proteinase 3
PTN pleiotrophin
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP1 secreted frizzled-related protein 1
SGCE sarcoglycan, epsilon
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPTBN1 spectrin, beta, non-erythrocytic 1
SYNM synemin, intermediate filament protein
TGFBR3 transforming growth factor, beta receptor III
TMX4 thioredoxin-related transmembrane protein 4
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D3 TSC22 domain family, member 3
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican
VNN1 vanin 1

decreased expression

Symbol Name
ABHD6 abhydrolase domain containing 6
AMD1 adenosylmethionine decarboxylase 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BEX4 brain expressed, X-linked 4
CDC42 cell division cycle 42
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CXADR coxsackie virus and adenovirus receptor
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
EPHA2 EPH receptor A2
FOSL1 FOS-like antigen 1
GNAS GNAS complex locus
GSPT2 G1 to S phase transition 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
LIMCH1 LIM and calponin homology domains 1
MALL mal, T-cell differentiation protein-like
MAP7 microtubule-associated protein 7
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MYH10 myosin, heavy chain 10, non-muscle
NDN necdin, melanoma antigen (MAGE) family member
ODC1 ornithine decarboxylase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PNP purine nucleoside phosphorylase
PTPRO protein tyrosine phosphatase, receptor type, O
RAI14 retinoic acid induced 14
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TFRC transferrin receptor
TLR4 toll-like receptor 4
TSPAN4 tetraspanin 4
WBP5 WW domain binding protein 5