BRD-K02708799_GSK-1059615_BT20_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

373 genes differentially expressed following the BRD-K02708799_GSK-1059615_BT20_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
AKAP8L A kinase (PRKA) anchor protein 8-like
AMPD3 adenosine monophosphate deaminase 3
ANKRD10 ankyrin repeat domain 10
APOE apolipoprotein E
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCL6 B-cell CLL/lymphoma 6
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C14ORF132 chromosome 14 open reading frame 132
CA11 carbonic anhydrase XI
CALCOCO1 calcium binding and coiled-coil domain 1
CAMLG calcium modulating ligand
CARS cysteinyl-tRNA synthetase
CCDC28A coiled-coil domain containing 28A
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CCNG2 cyclin G2
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN2 chimerin 2
CLEC2B C-type lectin domain family 2, member B
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CP ceruloplasmin (ferroxidase)
CPD carboxypeptidase D
CTGF connective tissue growth factor
CTSB cathepsin B
CYLD cylindromatosis (turban tumor syndrome)
CYTH1 cytohesin 1
DAZAP2 DAZ associated protein 2
DKFZP586I1420 uncharacterized protein DKFZp586I1420
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ECHDC2 enoyl CoA hydratase domain containing 2
EGFR epidermal growth factor receptor
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPCAM epithelial cell adhesion molecule
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
FAM129A family with sequence similarity 129, member A
FAM8A1 family with sequence similarity 8, member A1
FAP fibroblast activation protein, alpha
FAXDC2 fatty acid hydroxylase domain containing 2
FGG fibrinogen gamma chain
FGL1 fibrinogen-like 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FMO5 flavin containing monooxygenase 5
FOXN3 forkhead box N3
FOXO4 forkhead box O4
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA3 GATA binding protein 3
GLUL glutamate-ammonia ligase
GOLGA8H golgin A8 family, member H
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GREB1 growth regulation by estrogen in breast cancer 1
GRN granulin
HBP1 HMG-box transcription factor 1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HDAC5 histone deacetylase 5
HDAC6 histone deacetylase 6
HECA headcase homolog (Drosophila)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HLA-E major histocompatibility complex, class I, E
HOOK2 hook microtubule-tethering protein 2
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IGFBP1 insulin-like growth factor binding protein 1
IL17RB interleukin 17 receptor B
IL1R1 interleukin 1 receptor, type I
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INSR insulin receptor
IRS2 insulin receptor substrate 2
KIAA0430 KIAA0430
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
KRT15 keratin 15, type I
LGALS8 lectin, galactoside-binding, soluble, 8
LINC00342 long intergenic non-protein coding RNA 342
LRP10 low density lipoprotein receptor-related protein 10
LXN latexin
LY75 lymphocyte antigen 75
MACF1 microtubule-actin crosslinking factor 1
MCF2L MCF.2 cell line derived transforming sequence-like
METTL7A methyltransferase like 7A
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MUC16 mucin 16, cell surface associated
MXI1 MAX interactor 1, dimerization protein
N4BP2L1 NEDD4 binding protein 2-like 1
NAV2 neuron navigator 2
NBR1 neighbor of BRCA1 gene 1
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLIN2 perilipin 2
PMEL premelanosome protein
POSTN periostin, osteoblast specific factor
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAB17 RAB17, member RAS oncogene family
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RB1CC1 RB1-inducible coiled-coil 1
RBM47 RNA binding motif protein 47
RBP1 retinol binding protein 1, cellular
RGS10 regulator of G-protein signaling 10
RNASE4 ribonuclease, RNase A family, 4
RTN2 reticulon 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAMP1 secretory carrier membrane protein 1
SCG5 secretogranin V
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SHOX2 short stature homeobox 2
SLC35E2B solute carrier family 35, member E2B
SOD2 superoxide dismutase 2, mitochondrial
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STC1 stanniocalcin 1
STMN2 stathmin 2
STON1 stonin 1
SYNJ2 synaptojanin 2
SYT1 synaptotagmin I
TANK TRAF family member-associated NFKB activator
TF transferrin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS1 thrombospondin 1
TMEM59 transmembrane protein 59
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPBG trophoblast glycoprotein
TPP1 tripeptidyl peptidase I
TRIM13 tripartite motif containing 13
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VTCN1 V-set domain containing T cell activation inhibitor 1
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZSWIM8 zinc finger, SWIM-type containing 8

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
AHCY adenosylhomocysteinase
AK4 adenylate kinase 4
ALDOA aldolase A, fructose-bisphosphate
ANXA2 annexin A2
ANXA3 annexin A3
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATG3 autophagy related 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AXL AXL receptor tyrosine kinase
BAG2 BCL2-associated athanogene 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BZW2 basic leucine zipper and W2 domains 2
C1QBP complement component 1, q subcomponent binding protein
CA2 carbonic anhydrase II
CACYBP calcyclin binding protein
CAV2 caveolin 2
CCND1 cyclin D1
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDK4 cyclin-dependent kinase 4
CENPU centromere protein U
COL4A2 collagen, type IV, alpha 2
COL5A1 collagen, type V, alpha 1
COTL1 coactosin-like F-actin binding protein 1
COX11 COX11 cytochrome c oxidase copper chaperone
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP1 cysteine and glycine-rich protein 1
CTPS1 CTP synthase 1
CTSZ cathepsin Z
CYB5A cytochrome b5 type A (microsomal)
CYCS cytochrome c, somatic
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCTPP1 dCTP pyrophosphatase 1
DLC1 DLC1 Rho GTPase activating protein
DLD dihydrolipoamide dehydrogenase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBNA1BP2 EBNA1 binding protein 2
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF5A eukaryotic translation initiation factor 5A
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ENO1 enolase 1, (alpha)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FLNA filamin A, alpha
FLRT3 fibronectin leucine rich transmembrane protein 3
FOSL1 FOS-like antigen 1
GALE UDP-galactose-4-epimerase
GPI glucose-6-phosphate isomerase
GPM6A glycoprotein M6A
GSTP1 glutathione S-transferase pi 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HN1 hematological and neurological expressed 1
HOXB6 homeobox B6
HOXB7 homeobox B7
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGKV1-5 immunoglobulin kappa variable 1-5
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KCTD12 potassium channel tetramerization domain containing 12
KLF4 Kruppel-like factor 4 (gut)
KRT13 keratin 13, type I
KRT18 keratin 18, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS4 lectin, galactoside-binding, soluble, 4
LIMCH1 LIM and calponin homology domains 1
LOC100505650 uncharacterized LOC100505650
LPL lipoprotein lipase
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAK16 MAK16 homolog (S. cerevisiae)
MALL mal, T-cell differentiation protein-like
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL1 methyltransferase like 1
MFAP5 microfibrillar associated protein 5
MFSD10 major facilitator superfamily domain containing 10
MINA MYC induced nuclear antigen
MLF1 myeloid leukemia factor 1
MRPL12 mitochondrial ribosomal protein L12
MRPL24 mitochondrial ribosomal protein L24
MRPL3 mitochondrial ribosomal protein L3
MRPS7 mitochondrial ribosomal protein S7
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MSMO1 methylsterol monooxygenase 1
MTCH2 mitochondrial carrier 2
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYL9 myosin, light chain 9, regulatory
NDNF neuron-derived neurotrophic factor
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPR3 natriuretic peptide receptor 3
NRG1 neuregulin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NXN nucleoredoxin
OAZ1 ornithine decarboxylase antizyme 1
ODC1 ornithine decarboxylase 1
OLFM4 olfactomedin 4
P3H2 prolyl 3-hydroxylase 2
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PALLD palladin, cytoskeletal associated protein
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PEX3 peroxisomal biogenesis factor 3
PFKP phosphofructokinase, platelet
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PI3 peptidase inhibitor 3, skin-derived
PITRM1 pitrilysin metallopeptidase 1
PKM pyruvate kinase, muscle
PLBD1 phospholipase B domain containing 1
PMP22 peripheral myelin protein 22
PNP purine nucleoside phosphorylase
PON2 paraoxonase 2
PPA1 pyrophosphatase (inorganic) 1
PPARG peroxisome proliferator-activated receptor gamma
PRDX4 peroxiredoxin 4
PRMT1 protein arginine methyltransferase 1
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGES3 prostaglandin E synthase 3 (cytosolic)
PTRF polymerase I and transcript release factor
PXDN peroxidasin
PYCR1 pyrroline-5-carboxylate reductase 1
RAN RAN, member RAS oncogene family
RANBP1 RAN binding protein 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RPL26L1 ribosomal protein L26-like 1
RPP40 ribonuclease P/MRP 40kDa subunit
RRAD Ras-related associated with diabetes
RRM2 ribonucleotide reductase M2
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUVBL1 RuvB-like AAA ATPase 1
S100A10 S100 calcium binding protein A10
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SERBP1 SERPINE1 mRNA binding protein 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLPI secretory leukocyte peptidase inhibitor
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPE small nuclear ribonucleoprotein polypeptide E
SPRR1A small proline-rich protein 1A
SRM spermidine synthase
STRA13 stimulated by retinoic acid 13
TFRC transferrin receptor
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIPIN TIMELESS interacting protein
TKT transketolase
TMEM109 transmembrane protein 109
TNNC1 troponin C type 1 (slow)
TOX3 TOX high mobility group box family member 3
TPI1 triosephosphate isomerase 1
TPK1 thiamin pyrophosphokinase 1
TPM1 tropomyosin 1 (alpha)
TRIP13 thyroid hormone receptor interactor 13
TSPAN8 tetraspanin 8
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBE3C ubiquitin protein ligase E3C
VIM vimentin
WDR3 WD repeat domain 3
WDR77 WD repeat domain 77
WNT5A wingless-type MMTV integration site family, member 5A
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon