BRD-K02708799_GSK-1059615_BT20_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

312 genes differentially expressed following the BRD-K02708799_GSK-1059615_BT20_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADAM28 ADAM metallopeptidase domain 28
AKAP8L A kinase (PRKA) anchor protein 8-like
ANKRD10 ankyrin repeat domain 10
ANKRD36B ankyrin repeat domain 36B
APOE apolipoprotein E
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARMCX1 armadillo repeat containing, X-linked 1
ASPN asporin
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP11B ATPase, class VI, type 11B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BSG basigin (Ok blood group)
C10ORF10 chromosome 10 open reading frame 10
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CALCOCO1 calcium binding and coiled-coil domain 1
CALHM2 calcium homeostasis modulator 2
CCDC28A coiled-coil domain containing 28A
CCL20 chemokine (C-C motif) ligand 20
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDK19 cyclin-dependent kinase 19
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN1 chimerin 1
CLEC2B C-type lectin domain family 2, member B
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CPD carboxypeptidase D
CST7 cystatin F (leukocystatin)
CTSS cathepsin S
CYTH1 cytohesin 1
DCN decorin
DHRS3 dehydrogenase/reductase (SDR family) member 3
E2F2 E2F transcription factor 2
EGFR epidermal growth factor receptor
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
EVI2A ecotropic viral integration site 2A
F13A1 coagulation factor XIII, A1 polypeptide
FAM129A family with sequence similarity 129, member A
FAP fibroblast activation protein, alpha
FAXDC2 fatty acid hydroxylase domain containing 2
FKBP11 FK506 binding protein 11, 19 kDa
FOXO4 forkhead box O4
GAB2 GRB2-associated binding protein 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GAS6 growth arrest-specific 6
GATA3 GATA binding protein 3
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
GSDMB gasdermin B
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HOOK2 hook microtubule-tethering protein 2
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IDO1 indoleamine 2,3-dioxygenase 1
IFI16 interferon, gamma-inducible protein 16
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL1R1 interleukin 1 receptor, type I
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INSR insulin receptor
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
KIAA0430 KIAA0430
KIAA1551 KIAA1551
KLF9 Kruppel-like factor 9
LBH limb bud and heart development
LGALS8 lectin, galactoside-binding, soluble, 8
LINC00341 long intergenic non-protein coding RNA 341
LINC00342 long intergenic non-protein coding RNA 342
LRRC15 leucine rich repeat containing 15
LXN latexin
MACF1 microtubule-actin crosslinking factor 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2A1 mannosidase, alpha, class 2A, member 1
METTL7A methyltransferase like 7A
MOK MOK protein kinase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPTX2 neuronal pentraxin II
OLFM1 olfactomedin 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PILRB paired immunoglobin-like type 2 receptor beta
PLEKHA5 pleckstrin homology domain containing, family A member 5
POSTN periostin, osteoblast specific factor
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RNASE4 ribonuclease, RNase A family, 4
RSRP1 arginine/serine-rich protein 1
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCARB2 scavenger receptor class B, member 2
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC35E2B solute carrier family 35, member E2B
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SST somatostatin
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STK38L serine/threonine kinase 38 like
STX1A syntaxin 1A (brain)
TGIF1 TGFB-induced factor homeobox 1
TIMP3 TIMP metallopeptidase inhibitor 3
TNC tenascin C
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPBG trophoblast glycoprotein
TPP1 tripeptidyl peptidase I
TRA2A transformer 2 alpha homolog (Drosophila)
TRD T cell receptor delta locus
TRIB2 tribbles pseudokinase 2
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
TWIST1 twist family bHLH transcription factor 1
TXNIP thioredoxin interacting protein
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZNF217 zinc finger protein 217
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADGRG6 adhesion G protein-coupled receptor G6
ADSL adenylosuccinate lyase
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AK2 adenylate kinase 2
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA3 annexin A3
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ARHGAP29 Rho GTPase activating protein 29
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF5 activating transcription factor 5
ATG3 autophagy related 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B9D1 B9 protein domain 1
BAG2 BCL2-associated athanogene 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C1QBP complement component 1, q subcomponent binding protein
CACYBP calcyclin binding protein
CAPN6 calpain 6
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CBX1 chromobox homolog 1
CCNB1 cyclin B1
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CD24 CD24 molecule
CDC123 cell division cycle 123
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDK4 cyclin-dependent kinase 4
CETN2 centrin, EF-hand protein, 2
CLIC3 chloride intracellular channel 3
COL9A3 collagen, type IX, alpha 3
COTL1 coactosin-like F-actin binding protein 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP1 cysteine and glycine-rich protein 1
CYB5A cytochrome b5 type A (microsomal)
DCTPP1 dCTP pyrophosphatase 1
DEFA5 defensin, alpha 5, Paneth cell-specific
DES desmin
EIF5A eukaryotic translation initiation factor 5A
ELF5 E74-like factor 5 (ets domain transcription factor)
ENO1 enolase 1, (alpha)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM57A family with sequence similarity 57, member A
FASN fatty acid synthase
FERMT1 fermitin family member 1
FGFR2 fibroblast growth factor receptor 2
FLNA filamin A, alpha
FLRT3 fibronectin leucine rich transmembrane protein 3
GALE UDP-galactose-4-epimerase
GPI glucose-6-phosphate isomerase
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTM3 glutathione S-transferase mu 3 (brain)
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IRAK1 interleukin-1 receptor-associated kinase 1
KARS lysyl-tRNA synthetase
KAZN kazrin, periplakin interacting protein
KCTD12 potassium channel tetramerization domain containing 12
KRT17 keratin 17, type I
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LDHB lactate dehydrogenase B
LIMCH1 LIM and calponin homology domains 1
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LRRC59 leucine rich repeat containing 59
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAGED1 melanoma antigen family D1
MALL mal, T-cell differentiation protein-like
MAPK13 mitogen-activated protein kinase 13
MCAM melanoma cell adhesion molecule
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGLL monoglyceride lipase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MINA MYC induced nuclear antigen
MLF1 myeloid leukemia factor 1
MMP12 matrix metallopeptidase 12
MRPL12 mitochondrial ribosomal protein L12
MRPL3 mitochondrial ribosomal protein L3
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYL9 myosin, light chain 9, regulatory
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NRN1 neuritin 1
ODC1 ornithine decarboxylase 1
OLFM4 olfactomedin 4
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX3 pre-B-cell leukemia homeobox 3
PDLIM2 PDZ and LIM domain 2 (mystique)
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PFKP phosphofructokinase, platelet
PGAM1 phosphoglycerate mutase 1 (brain)
PGM1 phosphoglucomutase 1
PHB prohibitin
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PKM pyruvate kinase, muscle
PLAC8 placenta-specific 8
PLAGL1 pleiomorphic adenoma gene-like 1
PLCB4 phospholipase C, beta 4
PMP22 peripheral myelin protein 22
PNO1 partner of NOB1 homolog (S. cerevisiae)
PNP purine nucleoside phosphorylase
PON2 paraoxonase 2
PPARG peroxisome proliferator-activated receptor gamma
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRMT1 protein arginine methyltransferase 1
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTRF polymerase I and transcript release factor
PYCR1 pyrroline-5-carboxylate reductase 1
RALB v-ral simian leukemia viral oncogene homolog B
RAN RAN, member RAS oncogene family
RANBP1 RAN binding protein 1
RPP40 ribonuclease P/MRP 40kDa subunit
RUVBL1 RuvB-like AAA ATPase 1
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SDF2L1 stromal cell-derived factor 2-like 1
SELL selectin L
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A46 solute carrier family 25, member 46
SLPI secretory leukocyte peptidase inhibitor
SNRPE small nuclear ribonucleoprotein polypeptide E
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPRR1A small proline-rich protein 1A
SRM spermidine synthase
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN2 transgelin 2
TFRC transferrin receptor
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIPIN TIMELESS interacting protein
TMEM255A transmembrane protein 255A
TOX3 TOX high mobility group box family member 3
TPM1 tropomyosin 1 (alpha)
TRIP13 thyroid hormone receptor interactor 13
TSPAN8 tetraspanin 8
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBE2L3 ubiquitin-conjugating enzyme E2L 3
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
WDR61 WD repeat domain 61
WDR77 WD repeat domain 77
WNT5A wingless-type MMTV integration site family, member 5A
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon