BRD-K02708799_GSK-1059615_BT20_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

270 genes differentially expressed following the BRD-K02708799_GSK-1059615_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABHD4 abhydrolase domain containing 4
ACACB acetyl-CoA carboxylase beta
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
ADRB2 adrenoceptor beta 2, surface
AHSG alpha-2-HS-glycoprotein
ANKRD10 ankyrin repeat domain 10
ANPEP alanyl (membrane) aminopeptidase
APOA2 apolipoprotein A-II
APOB apolipoprotein B
APOD apolipoprotein D
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCL6 B-cell CLL/lymphoma 6
BLNK B-cell linker
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C6ORF62 chromosome 6 open reading frame 62
CALCOCO1 calcium binding and coiled-coil domain 1
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEMIP cell migration inducing protein, hyaluronan binding
CFB complement factor B
CFLAR CASP8 and FADD-like apoptosis regulator
CLDN3 claudin 3
CP ceruloplasmin (ferroxidase)
CTGF connective tissue growth factor
CTSB cathepsin B
CXCL3 chemokine (C-X-C motif) ligand 3
CYTH1 cytohesin 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DPP4 dipeptidyl-peptidase 4
DUSP6 dual specificity phosphatase 6
EIF4B eukaryotic translation initiation factor 4B
ELOVL2 ELOVL fatty acid elongase 2
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB3 erb-b2 receptor tyrosine kinase 3
EYA2 EYA transcriptional coactivator and phosphatase 2
F13A1 coagulation factor XIII, A1 polypeptide
FAM129A family with sequence similarity 129, member A
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOLR1 folate receptor 1 (adult)
FOXN3 forkhead box N3
FOXO4 forkhead box O4
FST follistatin
GABARAPL1 GABA(A) receptor-associated protein like 1
GCC2 GRIP and coiled-coil domain containing 2
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GSDMB gasdermin B
GSN gelsolin
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HNMT histamine N-methyltransferase
IFI16 interferon, gamma-inducible protein 16
IFITM1 interferon induced transmembrane protein 1
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INSR insulin receptor
IRS2 insulin receptor substrate 2
ISCU iron-sulfur cluster assembly enzyme
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD1C jumonji domain containing 1C
KIZ kizuna centrosomal protein
KLF9 Kruppel-like factor 9
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
LGALS8 lectin, galactoside-binding, soluble, 8
LRP10 low density lipoprotein receptor-related protein 10
LTF lactotransferrin
LXN latexin
LYZ lysozyme
MAN2B1 mannosidase, alpha, class 2B, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
METTL7A methyltransferase like 7A
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP13 matrix metallopeptidase 13
MSMB microseminoprotein, beta-
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
NMU neuromedin U
NUAK1 NUAK family, SNF1-like kinase, 1
OXTR oxytocin receptor
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PECR peroxisomal trans-2-enoyl-CoA reductase
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLIN2 perilipin 2
PLSCR4 phospholipid scramblase 4
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPARD peroxisome proliferator-activated receptor delta
PROM1 prominin 1
PTPRC protein tyrosine phosphatase, receptor type, C
RAD9A RAD9 homolog A (S. pombe)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RB1CC1 RB1-inducible coiled-coil 1
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RNASE4 ribonuclease, RNase A family, 4
RNASE6 ribonuclease, RNase A family, k6
RNF103 ring finger protein 103
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RPS27L ribosomal protein S27-like
RSRP1 arginine/serine-rich protein 1
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC44A4 solute carrier family 44, member 4
SMAD3 SMAD family member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SWAP70 SWAP switching B-cell complex 70kDa subunit
TCF4 transcription factor 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TF transferrin
TFF1 trefoil factor 1
TGIF1 TGFB-induced factor homeobox 1
THBS1 thrombospondin 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM50A transmembrane protein 50A
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPBG trophoblast glycoprotein
TPP1 tripeptidyl peptidase I
TRIM22 tripartite motif containing 22
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
TWIST1 twist family bHLH transcription factor 1
TXNIP thioredoxin interacting protein
UBE2B ubiquitin-conjugating enzyme E2B
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VAV3 vav 3 guanine nucleotide exchange factor
WDTC1 WD and tetratricopeptide repeats 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
AK1 adenylate kinase 1
AK2 adenylate kinase 2
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDOA aldolase A, fructose-bisphosphate
ANXA3 annexin A3
ASCL1 achaete-scute family bHLH transcription factor 1
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BZW2 basic leucine zipper and W2 domains 2
C1QBP complement component 1, q subcomponent binding protein
CAPN2 calpain 2, (m/II) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD200 CD200 molecule
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK4 cyclin-dependent kinase 4
CENPU centromere protein U
CLIC3 chloride intracellular channel 3
CNN1 calponin 1, basic, smooth muscle
COTL1 coactosin-like F-actin binding protein 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP1 cysteine and glycine-rich protein 1
CTPS1 CTP synthase 1
CYCS cytochrome c, somatic
DCTPP1 dCTP pyrophosphatase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
ENOPH1 enolase-phosphatase 1
EXT1 exostosin glycosyltransferase 1
FAM57A family with sequence similarity 57, member A
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
GAGE3 G antigen 3
GALE UDP-galactose-4-epimerase
GGCT gamma-glutamylcyclotransferase
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLS glutaminase
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPI glucose-6-phosphate isomerase
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KLF4 Kruppel-like factor 4 (gut)
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LIMCH1 LIM and calponin homology domains 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MALL mal, T-cell differentiation protein-like
MATN2 matrilin 2
MBOAT7 membrane bound O-acyltransferase domain containing 7
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MMP12 matrix metallopeptidase 12
MRPL12 mitochondrial ribosomal protein L12
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYL9 myosin, light chain 9, regulatory
MYOF myoferlin
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOP16 NOP16 nucleolar protein
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPR3 natriuretic peptide receptor 3
ODC1 ornithine decarboxylase 1
P3H2 prolyl 3-hydroxylase 2
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PALLD palladin, cytoskeletal associated protein
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PEA15 phosphoprotein enriched in astrocytes 15
PFKP phosphofructokinase, platelet
PGM1 phosphoglucomutase 1
PKM pyruvate kinase, muscle
PLBD1 phospholipase B domain containing 1
PMP22 peripheral myelin protein 22
PNP purine nucleoside phosphorylase
PPARG peroxisome proliferator-activated receptor gamma
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRMT1 protein arginine methyltransferase 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTRF polymerase I and transcript release factor
RAN RAN, member RAS oncogene family
RANBP1 RAN binding protein 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RFC2 replication factor C (activator 1) 2, 40kDa
SFN stratifin
SLPI secretory leukocyte peptidase inhibitor
SQLE squalene epoxidase
SRM spermidine synthase
TAGLN2 transgelin 2
TFRC transferrin receptor
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TPM1 tropomyosin 1 (alpha)
TPM4 tropomyosin 4
TYMS thymidylate synthetase
XIST X inactive specific transcript (non-protein coding)