BRD-K02708799_GSK-1059615_BT20_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

231 genes differentially expressed following the BRD-K02708799_GSK-1059615_BT20_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANO1 anoctamin 1, calcium activated chloride channel
APOD apolipoprotein D
ARMCX1 armadillo repeat containing, X-linked 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BST2 bone marrow stromal cell antigen 2
C10ORF10 chromosome 10 open reading frame 10
CA11 carbonic anhydrase XI
CCDC28A coiled-coil domain containing 28A
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFB complement factor B
CFLAR CASP8 and FADD-like apoptosis regulator
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL3A1 collagen, type III, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CSTA cystatin A (stefin A)
CXCL3 chemokine (C-X-C motif) ligand 3
CYTH1 cytohesin 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
F13A1 coagulation factor XIII, A1 polypeptide
FAM134C family with sequence similarity 134, member C
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOXN3 forkhead box N3
FOXO4 forkhead box O4
GABARAPL1 GABA(A) receptor-associated protein like 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCC2 GRIP and coiled-coil domain containing 2
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
GRB7 growth factor receptor-bound protein 7
GSDMB gasdermin B
HBP1 HMG-box transcription factor 1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HECA headcase homolog (Drosophila)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGFBP7 insulin-like growth factor binding protein 7
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INSR insulin receptor
IRS2 insulin receptor substrate 2
ISYNA1 inositol-3-phosphate synthase 1
KIF14 kinesin family member 14
KLF9 Kruppel-like factor 9
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
LCN2 lipocalin 2
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS8 lectin, galactoside-binding, soluble, 8
LMO2 LIM domain only 2 (rhombotin-like 1)
LRP10 low density lipoprotein receptor-related protein 10
MAGED2 melanoma antigen family D2
METTL7A methyltransferase like 7A
MFAP2 microfibrillar-associated protein 2
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
MVP major vault protein
MYO6 myosin VI
N4BP2L2 NEDD4 binding protein 2-like 2
NBR1 neighbor of BRCA1 gene 1
NCOA2 nuclear receptor coactivator 2
NOTCH2NL notch 2 N-terminal like
PDZK1 PDZ domain containing 1
PDZK1IP1 PDZK1 interacting protein 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POSTN periostin, osteoblast specific factor
PTGES prostaglandin E synthase
QPRT quinolinate phosphoribosyltransferase
RALGDS ral guanine nucleotide dissociation stimulator
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBM47 RNA binding motif protein 47
RBP1 retinol binding protein 1, cellular
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE4 ribonuclease, RNase A family, 4
RSRP1 arginine/serine-rich protein 1
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC38A2 solute carrier family 38, member 2
SMAD3 SMAD family member 3
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SST somatostatin
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STON1 stonin 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TANK TRAF family member-associated NFKB activator
TFF1 trefoil factor 1
TMEM50A transmembrane protein 50A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPBG trophoblast glycoprotein
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VCAN versican
WDR45 WD repeat domain 45
WDTC1 WD and tetratricopeptide repeats 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ADM adrenomedullin
AGR2 anterior gradient 2
AK1 adenylate kinase 1
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA3 annexin A3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK4 cyclin-dependent kinase 4
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP1 cysteine and glycine-rich protein 1
CYCS cytochrome c, somatic
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DKC1 dyskeratosis congenita 1, dyskerin
ELAVL1 ELAV like RNA binding protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FASN fatty acid synthase
FLNA filamin A, alpha
FLRT3 fibronectin leucine rich transmembrane protein 3
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GGCT gamma-glutamylcyclotransferase
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
H2AFX H2A histone family, member X
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOMER1 homer scaffolding protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
JUN jun proto-oncogene
KAZN kazrin, periplakin interacting protein
KLF4 Kruppel-like factor 4 (gut)
KRT13 keratin 13, type I
KRT18 keratin 18, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3 lectin, galactoside-binding, soluble, 3
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MOCOS molybdenum cofactor sulfurase
MRPL12 mitochondrial ribosomal protein L12
MRPL3 mitochondrial ribosomal protein L3
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NEFL neurofilament, light polypeptide
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PFKP phosphofructokinase, platelet
PGM1 phosphoglucomutase 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMP22 peripheral myelin protein 22
PNP purine nucleoside phosphorylase
PPARG peroxisome proliferator-activated receptor gamma
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTRF polymerase I and transcript release factor
RANBP1 RAN binding protein 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RFC2 replication factor C (activator 1) 2, 40kDa
RPP40 ribonuclease P/MRP 40kDa subunit
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SFN stratifin
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SRPRB signal recognition particle receptor, B subunit
TFRC transferrin receptor
TIPIN TIMELESS interacting protein
TPM1 tropomyosin 1 (alpha)
TSC22D1 TSC22 domain family, member 1
TYMS thymidylate synthetase
WARS tryptophanyl-tRNA synthetase
WDR3 WD repeat domain 3
WSB2 WD repeat and SOCS box containing 2
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZYX zyxin