BRD-K02708799_GSK-1059615_A549_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

449 genes differentially expressed following the BRD-K02708799_GSK-1059615_A549_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABLIM1 actin binding LIM protein 1
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADRB2 adrenoceptor beta 2, surface
AGR2 anterior gradient 2
AGTR1 angiotensin II receptor, type 1
AHNAK AHNAK nucleoprotein
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALCAM activated leukocyte cell adhesion molecule
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA4 annexin A4
ANXA5 annexin A5
APLP2 amyloid beta (A4) precursor-like protein 2
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ATP9A ATPase, class II, type 9A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
BHLHE41 basic helix-loop-helix family, member e41
BRD2 bromodomain containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAMLG calcium modulating ligand
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC92 coiled-coil domain containing 92
CCL5 chemokine (C-C motif) ligand 5
CCNG2 cyclin G2
CD302 CD302 molecule
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDK19 cyclin-dependent kinase 19
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLEC7A C-type lectin domain family 7, member A
CLU clusterin
COBL cordon-bleu WH2 repeat protein
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL4A5 collagen, type IV, alpha 5
COL5A2 collagen, type V, alpha 2
COL7A1 collagen, type VII, alpha 1
CPD carboxypeptidase D
CREBL2 cAMP responsive element binding protein-like 2
CST1 cystatin SN
CTSB cathepsin B
CUX1 cut-like homeobox 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYBA cytochrome b-245, alpha polypeptide
CYTH1 cytohesin 1
DAPK1 death-associated protein kinase 1
DCLK1 doublecortin-like kinase 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEPTOR DEP domain containing MTOR-interacting protein
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DOCK9 dedicator of cytokinesis 9
DPP4 dipeptidyl-peptidase 4
DST dystonin
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EGR2 early growth response 2
EIF4B eukaryotic translation initiation factor 4B
EML3 echinoderm microtubule associated protein like 3
ERBB2 erb-b2 receptor tyrosine kinase 2
ESD esterase D
F5 coagulation factor V (proaccelerin, labile factor)
FABP4 fatty acid binding protein 4, adipocyte
FAM63A family with sequence similarity 63, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FBN1 fibrillin 1
FILIP1L filamin A interacting protein 1-like
FLNB filamin B, beta
FN1 fibronectin 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO4 forkhead box O4
GAA glucosidase, alpha; acid
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GALC galactosylceramidase
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLGA8H golgin A8 family, member H
GOLGB1 golgin B1
GPER1 G protein-coupled estrogen receptor 1
GRN granulin
GSE1 Gse1 coiled-coil protein
GSN gelsolin
HBP1 HMG-box transcription factor 1
HDAC6 histone deacetylase 6
HEBP1 heme binding protein 1
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-E major histocompatibility complex, class I, E
HOPX HOP homeobox
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGFBP7 insulin-like growth factor binding protein 7
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGAV integrin, alpha V
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JAG1 jagged 1
KDM5D lysine (K)-specific demethylase 5D
KIZ kizuna centrosomal protein
KLHL21 kelch-like family member 21
KRT17 keratin 17, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LAMB1 laminin, beta 1
LDOC1 leucine zipper, down-regulated in cancer 1
LETMD1 LETM1 domain containing 1
LGALS2 lectin, galactoside-binding, soluble, 2
LGALS8 lectin, galactoside-binding, soluble, 8
LOXL2 lysyl oxidase-like 2
LTA4H leukotriene A4 hydrolase
LTBP3 latent transforming growth factor beta binding protein 3
LTF lactotransferrin
LXN latexin
LYPD3 LY6/PLAUR domain containing 3
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MAN2A1 mannosidase, alpha, class 2A, member 1
MAOA monoamine oxidase A
MET MET proto-oncogene, receptor tyrosine kinase
MTMR11 myotubularin related protein 11
MX2 MX dynamin-like GTPase 2
MYLK myosin light chain kinase
MYO6 myosin VI
MYOF myoferlin
MYRF myelin regulatory factor
MZF1 myeloid zinc finger 1
N4BP2L2 NEDD4 binding protein 2-like 2
NBR1 neighbor of BRCA1 gene 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NINL ninein-like
NKX3-1 NK3 homeobox 1
NMT2 N-myristoyltransferase 2
NNMT nicotinamide N-methyltransferase
NPEPL1 aminopeptidase-like 1
NT5E 5'-nucleotidase, ecto (CD73)
NUAK1 NUAK family, SNF1-like kinase, 1
OBSL1 obscurin-like 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAM peptidylglycine alpha-amidating monooxygenase
PAWR PRKC, apoptosis, WT1, regulator
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PDGFD platelet derived growth factor D
PDZK1IP1 PDZK1 interacting protein 1
PIEZO2 piezo-type mechanosensitive ion channel component 2
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PINK1 PTEN induced putative kinase 1
PLS3 plastin 3
PODXL podocalyxin-like
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLR1D polymerase (RNA) I polypeptide D, 16kDa
POSTN periostin, osteoblast specific factor
PROS1 protein S (alpha)
PSAP prosaposin
PTN pleiotrophin
PXDN peroxidasin
QARS glutaminyl-tRNA synthetase
QPCT glutaminyl-peptide cyclotransferase
R3HDM4 R3H domain containing 4
RAB40B RAB40B, member RAS oncogene family
RALGDS ral guanine nucleotide dissociation stimulator
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBP1 retinol binding protein 1, cellular
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNASE4 ribonuclease, RNase A family, 4
RPL28 ribosomal protein L28
RPL31 ribosomal protein L31
RSRP1 arginine/serine-rich protein 1
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SDPR serum deprivation response
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SH3BGRL SH3 domain binding glutamate-rich protein like
SIDT2 SID1 transmembrane family, member 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMAD3 SMAD family member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STOM stomatin
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
SYT1 synaptotagmin I
TACSTD2 tumor-associated calcium signal transducer 2
TCEA2 transcription elongation factor A (SII), 2
TCF25 transcription factor 25 (basic helix-loop-helix)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGM2 transglutaminase 2
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMC5 transmembrane channel-like 5
TMSB15A thymosin beta 15a
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TP53 tumor protein p53
TPM1 tropomyosin 1 (alpha)
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
TRIM22 tripartite motif containing 22
TRIM8 tripartite motif containing 8
TSPAN8 tetraspanin 8
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
VWF von Willebrand factor
WIPI1 WD repeat domain, phosphoinositide interacting 1
WNK1 WNK lysine deficient protein kinase 1
YPEL5 yippee-like 5 (Drosophila)
ZNF185 zinc finger protein 185 (LIM domain)
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
AK1 adenylate kinase 1
ALDOA aldolase A, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASF1B anti-silencing function 1B histone chaperone
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATAD2 ATPase family, AAA domain containing 2
ATF3 activating transcription factor 3
AURKA aurora kinase A
BAG2 BCL2-associated athanogene 2
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BTG3 BTG family, member 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C3ORF14 chromosome 3 open reading frame 14
C7 complement component 7
CA2 carbonic anhydrase II
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND3 cyclin D3
CCP110 centriolar coiled coil protein 110kDa
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEMIP cell migration inducing protein, hyaluronan binding
CENPN centromere protein N
CENPU centromere protein U
CKAP4 cytoskeleton-associated protein 4
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CTSZ cathepsin Z
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CYCS cytochrome c, somatic
DBF4 DBF4 zinc finger
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DHCR24 24-dehydrocholesterol reductase
DHFR dihydrofolate reductase
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
DSC2 desmocollin 2
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECM1 extracellular matrix protein 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELN elastin
EXO1 exonuclease 1
FABP1 fatty acid binding protein 1, liver
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FEN1 flap structure-specific endonuclease 1
FGFBP1 fibroblast growth factor binding protein 1
FKBP14 FK506 binding protein 14, 22 kDa
GCLM glutamate-cysteine ligase, modifier subunit
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GMNN geminin, DNA replication inhibitor
GPM6B glycoprotein M6B
GREM1 gremlin 1, DAN family BMP antagonist
GRWD1 glutamate-rich WD repeat containing 1
HAT1 histone acetyltransferase 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA14 heat shock 70kDa protein 14
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IL13RA2 interleukin 13 receptor, alpha 2
IL1RN interleukin 1 receptor antagonist
KAZN kazrin, periplakin interacting protein
KIAA0226L KIAA0226-like
KIF14 kinesin family member 14
KRT13 keratin 13, type I
KRT4 keratin 4, type II
KRT5 keratin 5, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LMNB1 lamin B1
LMO4 LIM domain only 4
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LUM lumican
LYZ lysozyme
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAL mal, T-cell differentiation protein
MALL mal, T-cell differentiation protein-like
MAPK13 mitogen-activated protein kinase 13
MARS methionyl-tRNA synthetase
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MEIS2 Meis homeobox 2
MFAP4 microfibrillar-associated protein 4
MMP12 matrix metallopeptidase 12
MRPL13 mitochondrial ribosomal protein L13
MRPL35 mitochondrial ribosomal protein L35
MRPS30 mitochondrial ribosomal protein S30
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NDC1 NDC1 transmembrane nucleoporin
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NET1 neuroepithelial cell transforming 1
ODC1 ornithine decarboxylase 1
OIP5 Opa interacting protein 5
ORC6 origin recognition complex, subunit 6
PBK PDZ binding kinase
PCCA propionyl CoA carboxylase, alpha polypeptide
PCP4 Purkinje cell protein 4
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PDZK1 PDZ domain containing 1
PFN2 profilin 2
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIR pirin (iron-binding nuclear protein)
PITX1 paired-like homeodomain 1
PLK4 polo-like kinase 4
PLP1 proteolipid protein 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNO1 partner of NOB1 homolog (S. cerevisiae)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKCB protein kinase C, beta
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAD51C RAD51 paralog C
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS1 regulator of G-protein signaling 1
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB1D2 secretoglobin, family 1D, member 2
SFN stratifin
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPC25 SPC25, NDC80 kinetochore complex component
SPINK5 serine peptidase inhibitor, Kazal type 5
SRM spermidine synthase
SRSF10 serine/arginine-rich splicing factor 10
SRSF3 serine/arginine-rich splicing factor 3
STEAP1 six transmembrane epithelial antigen of the prostate 1
STRA13 stimulated by retinoic acid 13
TARP TCR gamma alternate reading frame protein
TCL1A T-cell leukemia/lymphoma 1A
TFRC transferrin receptor
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOB1 transducer of ERBB2, 1
TOMM34 translocase of outer mitochondrial membrane 34
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TSPAN4 tetraspanin 4
TUBG1 tubulin, gamma 1
TXNDC9 thioredoxin domain containing 9
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
UGCG UDP-glucose ceramide glucosyltransferase
VRK1 vaccinia related kinase 1
WDR77 WD repeat domain 77
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZBTB18 zinc finger and BTB domain containing 18
ZWINT ZW10 interacting kinetochore protein