BRD-K02708799_GSK-1059615_A549_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

458 genes differentially expressed following the BRD-K02708799_GSK-1059615_A549_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AGR2 anterior gradient 2
AHNAK2 AHNAK nucleoprotein 2
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
ATP9A ATPase, class II, type 9A
AXIN1 axin 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BEX1 brain expressed, X-linked 1
C6ORF48 chromosome 6 open reading frame 48
C8ORF4 chromosome 8 open reading frame 4
CALCOCO1 calcium binding and coiled-coil domain 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAMLG calcium modulating ligand
CCDC92 coiled-coil domain containing 92
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK19 cyclin-dependent kinase 19
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CFB complement factor B
CIRBP cold inducible RNA binding protein
CLDN5 claudin 5
CLU clusterin
CNR1 cannabinoid receptor 1 (brain)
COL4A1 collagen, type IV, alpha 1
COL9A2 collagen, type IX, alpha 2
COLEC12 collectin sub-family member 12
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CUL7 cullin 7
CYBA cytochrome b-245, alpha polypeptide
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEPTOR DEP domain containing MTOR-interacting protein
DHRS3 dehydrogenase/reductase (SDR family) member 3
DHRS7 dehydrogenase/reductase (SDR family) member 7
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DOCK9 dedicator of cytokinesis 9
DPYD dihydropyrimidine dehydrogenase
DST dystonin
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4B eukaryotic translation initiation factor 4B
ELOVL4 ELOVL fatty acid elongase 4
EPAS1 endothelial PAS domain protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
ERGIC3 ERGIC and golgi 3
EXT1 exostosin glycosyltransferase 1
FAM114A1 family with sequence similarity 114, member A1
FAXDC2 fatty acid hydroxylase domain containing 2
FBN1 fibrillin 1
FGFR2 fibroblast growth factor receptor 2
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLNA filamin A, alpha
FN1 fibronectin 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXN3 forkhead box N3
FOXO4 forkhead box O4
GAA glucosidase, alpha; acid
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GALC galactosylceramidase
GJA1 gap junction protein, alpha 1, 43kDa
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GOLGB1 golgin B1
GPX3 glutathione peroxidase 3
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRN granulin
GSE1 Gse1 coiled-coil protein
GSN gelsolin
GSTZ1 glutathione S-transferase zeta 1
HBP1 HMG-box transcription factor 1
HDAC6 histone deacetylase 6
HEBP1 heme binding protein 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IGBP1 immunoglobulin (CD79A) binding protein 1
IGFBP7 insulin-like growth factor binding protein 7
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INPP1 inositol polyphosphate-1-phosphatase
INSR insulin receptor
IRS2 insulin receptor substrate 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGB4 integrin, beta 4
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIZ kizuna centrosomal protein
KLF9 Kruppel-like factor 9
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LDOC1 leucine zipper, down-regulated in cancer 1
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS8 lectin, galactoside-binding, soluble, 8
LOC399491
LTA4H leukotriene A4 hydrolase
LTBP3 latent transforming growth factor beta binding protein 3
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2A1 mannosidase, alpha, class 2A, member 1
MAOA monoamine oxidase A
MCAM melanoma cell adhesion molecule
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MID1 midline 1
MMP7 matrix metallopeptidase 7
MN1 meningioma (disrupted in balanced translocation) 1
MNT MAX network transcriptional repressor
MPPED2 metallophosphoesterase domain containing 2
MT1E metallothionein 1E
MT1M metallothionein 1M
MTMR11 myotubularin related protein 11
MVP major vault protein
MXD4 MAX dimerization protein 4
MYO1D myosin ID
MYOF myoferlin
NAV2 neuron navigator 2
NDRG1 N-myc downstream regulated 1
NPEPL1 aminopeptidase-like 1
NT5E 5'-nucleotidase, ecto (CD73)
OBSL1 obscurin-like 1
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PAM peptidylglycine alpha-amidating monooxygenase
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFC platelet derived growth factor C
PGLS 6-phosphogluconolactonase
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLS3 plastin 3
PLSCR3 phospholipid scramblase 3
PLXND1 plexin D1
PNRC1 proline-rich nuclear receptor coactivator 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLR1D polymerase (RNA) I polypeptide D, 16kDa
POSTN periostin, osteoblast specific factor
PRAF2 PRA1 domain family, member 2
PRUNE2 prune homolog 2 (Drosophila)
PYGL phosphorylase, glycogen, liver
QARS glutaminyl-tRNA synthetase
QPCT glutaminyl-peptide cyclotransferase
R3HDM2 R3H domain containing 2
RALGDS ral guanine nucleotide dissociation stimulator
RAP1GAP RAP1 GTPase activating protein
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RNASE4 ribonuclease, RNase A family, 4
RNF167 ring finger protein 167
RPL22 ribosomal protein L22
RPL28 ribosomal protein L28
RPS27L ribosomal protein S27-like
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RSL1D1 ribosomal L1 domain containing 1
RSRP1 arginine/serine-rich protein 1
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFXN3 sideroflexin 3
SIDT2 SID1 transmembrane family, member 2
SLC35E2B solute carrier family 35, member E2B
SLC38A1 solute carrier family 38, member 1
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
STX1A syntaxin 1A (brain)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYNJ2 synaptojanin 2
SYNM synemin, intermediate filament protein
SYT17 synaptotagmin XVII
TCEA2 transcription elongation factor A (SII), 2
TCF25 transcription factor 25 (basic helix-loop-helix)
TF transferrin
TFF1 trefoil factor 1
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE2 transducin-like enhancer of split 2
TMEM30B transmembrane protein 30B
TP53 tumor protein p53
TP53I3 tumor protein p53 inducible protein 3
TPCN1 two pore segment channel 1
TPM1 tropomyosin 1 (alpha)
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
TRIM8 tripartite motif containing 8
TSC22D1 TSC22 domain family, member 1
TTC3 tetratricopeptide repeat domain 3
TXNIP thioredoxin interacting protein
UBXN1 UBX domain protein 1
UBXN7 UBX domain protein 7
UGDH UDP-glucose 6-dehydrogenase
USP9X ubiquitin specific peptidase 9, X-linked
VAT1 vesicle amine transport 1
VEGFC vascular endothelial growth factor C
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
VWF von Willebrand factor
WDR13 WD repeat domain 13
WDR45 WD repeat domain 45
WNK1 WNK lysine deficient protein kinase 1
WNT5A wingless-type MMTV integration site family, member 5A
XYLT1 xylosyltransferase I
YPEL5 yippee-like 5 (Drosophila)
ZNF185 zinc finger protein 185 (LIM domain)
ZNF277 zinc finger protein 277
ZNF91 zinc finger protein 91
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ADI1 acireductone dioxygenase 1
AEBP1 AE binding protein 1
AK1 adenylate kinase 1
AK4 adenylate kinase 4
ALG8 ALG8, alpha-1,3-glucosyltransferase
ARPC5L actin related protein 2/3 complex, subunit 5-like
ASF1A anti-silencing function 1A histone chaperone
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
AUNIP aurora kinase A and ninein interacting protein
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BAG2 BCL2-associated athanogene 2
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCDC86 coiled-coil domain containing 86
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND3 cyclin D3
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPN centromere protein N
CENPU centromere protein U
CHEK2 checkpoint kinase 2
CLIC4 chloride intracellular channel 4
CNN3 calponin 3, acidic
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL5 chemokine (C-X-C motif) ligand 5
CYB5A cytochrome b5 type A (microsomal)
CYCS cytochrome c, somatic
DACH1 dachshund family transcription factor 1
DBF4 DBF4 zinc finger
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DHFR dihydrofolate reductase
DNA2 DNA replication helicase/nuclease 2
DPT dermatopontin
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EDNRB endothelin receptor type B
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELAVL1 ELAV like RNA binding protein 1
ENO1 enolase 1, (alpha)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ESR1 estrogen receptor 1
EXO1 exonuclease 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FH fumarate hydratase
FKBP14 FK506 binding protein 14, 22 kDa
FOLR1 folate receptor 1 (adult)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GBP1 guanylate binding protein 1, interferon-inducible
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GINS4 GINS complex subunit 4 (Sld5 homolog)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HAT1 histone acetyltransferase 1
HBB hemoglobin, beta
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXB6 homeobox B6
HSPB8 heat shock 22kDa protein 8
IGKC immunoglobulin kappa constant
IGKV4-1 immunoglobulin kappa variable 4-1
IL13RA2 interleukin 13 receptor, alpha 2
IL1RAP interleukin 1 receptor accessory protein
IL1RN interleukin 1 receptor antagonist
IL32 interleukin 32
IL7R interleukin 7 receptor
KRT10 keratin 10, type I
KRT13 keratin 13, type I
KRT4 keratin 4, type II
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LMNB1 lamin B1
LMO4 LIM domain only 4
LOXL1 lysyl oxidase-like 1
LRRC17 leucine rich repeat containing 17
LRRC59 leucine rich repeat containing 59
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAK16 MAK16 homolog (S. cerevisiae)
MAL mal, T-cell differentiation protein
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MFAP4 microfibrillar-associated protein 4
MKI67 marker of proliferation Ki-67
MMP12 matrix metallopeptidase 12
MPZL1 myelin protein zero-like 1
MRPL35 mitochondrial ribosomal protein L35
MRPS28 mitochondrial ribosomal protein S28
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAV3 neuron navigator 3
NDC1 NDC1 transmembrane nucleoporin
NFIL3 nuclear factor, interleukin 3 regulated
NLRP2 NLR family, pyrin domain containing 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP88 nucleoporin 88kDa
ODC1 ornithine decarboxylase 1
OIP5 Opa interacting protein 5
ORC6 origin recognition complex, subunit 6
PAK1IP1 PAK1 interacting protein 1
PBK PDZ binding kinase
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDHX pyruvate dehydrogenase complex, component X
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PEA15 phosphoprotein enriched in astrocytes 15
PEX3 peroxisomal biogenesis factor 3
PGC progastricsin (pepsinogen C)
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
PITX1 paired-like homeodomain 1
PLK1 polo-like kinase 1
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PPIF peptidylprolyl isomerase F
PRAME preferentially expressed antigen in melanoma
PROSC proline synthetase co-transcribed homolog (bacterial)
PRPF4 pre-mRNA processing factor 4
PSAT1 phosphoserine aminotransferase 1
PSMC3IP PSMC3 interacting protein
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAD51 RAD51 recombinase
RAE1 ribonucleic acid export 1
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RHOB ras homolog family member B
RPIA ribose 5-phosphate isomerase A
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCARB1 scavenger receptor class B, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SDHAF3 succinate dehydrogenase complex assembly factor 3
SELL selectin L
SFN stratifin
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPG small nuclear ribonucleoprotein polypeptide G
SNX11 sorting nexin 11
SPINK5 serine peptidase inhibitor, Kazal type 5
SPP1 secreted phosphoprotein 1
SPRR1A small proline-rich protein 1A
SPRR3 small proline-rich protein 3
SRM spermidine synthase
SRSF10 serine/arginine-rich splicing factor 10
SRSF7 serine/arginine-rich splicing factor 7
SSR1 signal sequence receptor, alpha
STRA13 stimulated by retinoic acid 13
TCL1A T-cell leukemia/lymphoma 1A
TDO2 tryptophan 2,3-dioxygenase
TEX30 testis expressed 30
TFAM transcription factor A, mitochondrial
TFRC transferrin receptor
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM38B transmembrane protein 38B
TMEM70 transmembrane protein 70
TMPO thymopoietin
TOX3 TOX high mobility group box family member 3
TPSAB1 tryptase alpha/beta 1
TRIP13 thyroid hormone receptor interactor 13
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
USP1 ubiquitin specific peptidase 1
VAV3 vav 3 guanine nucleotide exchange factor
VRK1 vaccinia related kinase 1
WT1 Wilms tumor 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZBTB18 zinc finger and BTB domain containing 18
ZWINT ZW10 interacting kinetochore protein