BRD-K02708799_GSK-1059615_A375_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

348 genes differentially expressed following the BRD-K02708799_GSK-1059615_A375_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALCAM activated leukocyte cell adhesion molecule
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ALDOA aldolase A, fructose-bisphosphate
ANXA1 annexin A1
ANXA4 annexin A4
APOLD1 apolipoprotein L domain containing 1
ASPN asporin
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
C2CD2 C2 calcium-dependent domain containing 2
C6ORF48 chromosome 6 open reading frame 48
CADPS2 Ca++-dependent secretion activator 2
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CD93 CD93 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEMIP cell migration inducing protein, hyaluronan binding
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKB creatine kinase, brain
CLEC11A C-type lectin domain family 11, member A
COCH cochlin
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
CP ceruloplasmin (ferroxidase)
CPA3 carboxypeptidase A3 (mast cell)
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DCN decorin
DDAH1 dimethylarginine dimethylaminohydrolase 1
DEPTOR DEP domain containing MTOR-interacting protein
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYSL3 dihydropyrimidinase-like 3
DSP desmoplakin
EFNB2 ephrin-B2
EGR2 early growth response 2
EIF4B eukaryotic translation initiation factor 4B
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EMP1 epithelial membrane protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV1 ets variant 1
ETV5 ets variant 5
EXPH5 exophilin 5
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM117A family with sequence similarity 117, member A
FBN1 fibrillin 1
FBXL12 F-box and leucine-rich repeat protein 12
FGFR3 fibroblast growth factor receptor 3
FHOD3 formin homology 2 domain containing 3
FLRT2 fibronectin leucine rich transmembrane protein 2
FOXN3 forkhead box N3
FXYD3 FXYD domain containing ion transport regulator 3
FZD6 frizzled class receptor 6
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GAS1 growth arrest-specific 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GREM1 gremlin 1, DAN family BMP antagonist
GSDMB gasdermin B
GSN gelsolin
GSPT2 G1 to S phase transition 2
GSTA4 glutathione S-transferase alpha 4
GSTP1 glutathione S-transferase pi 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBEGF heparin-binding EGF-like growth factor
HDAC6 histone deacetylase 6
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HIST1H2BD histone cluster 1, H2bd
HLA-B major histocompatibility complex, class I, B
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOOK2 hook microtubule-tethering protein 2
HOXD1 homeobox D1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDO1 indoleamine 2,3-dioxygenase 1
IDS iduronate 2-sulfatase
IFI6 interferon, alpha-inducible protein 6
IGF1R insulin-like growth factor 1 receptor
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS2 insulin receptor substrate 2
JAG1 jagged 1
KLK11 kallikrein-related peptidase 11
KRT19 keratin 19, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIMCH1 LIM and calponin homology domains 1
LMOD1 leiomodin 1 (smooth muscle)
LRRC15 leucine rich repeat containing 15
LUM lumican
LY75 lymphocyte antigen 75
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGED1 melanoma antigen family D1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MDK midkine (neurite growth-promoting factor 2)
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MEIS1 Meis homeobox 1
MFAP5 microfibrillar associated protein 5
MMP1 matrix metallopeptidase 1
MSLN mesothelin
MTMR11 myotubularin related protein 11
MUC16 mucin 16, cell surface associated
MVP major vault protein
MX2 MX dynamin-like GTPase 2
MXRA5 matrix-remodelling associated 5
MYL9 myosin, light chain 9, regulatory
NARFL nuclear prelamin A recognition factor-like
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NPR3 natriuretic peptide receptor 3
NR4A2 nuclear receptor subfamily 4, group A, member 2
NREP neuronal regeneration related protein
NT5E 5'-nucleotidase, ecto (CD73)
ORAI3 ORAI calcium release-activated calcium modulator 3
PDGFC platelet derived growth factor C
PDLIM1 PDZ and LIM domain 1
PDLIM4 PDZ and LIM domain 4
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PDZK1IP1 PDZK1 interacting protein 1
PERP PERP, TP53 apoptosis effector
PFDN5 prefoldin subunit 5
PFKL phosphofructokinase, liver
PLCB4 phospholipase C, beta 4
PLEC plectin
POSTN periostin, osteoblast specific factor
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRAME preferentially expressed antigen in melanoma
PXMP2 peroxisomal membrane protein 2, 22kDa
PYCARD PYD and CARD domain containing
PYGL phosphorylase, glycogen, liver
RALGDS ral guanine nucleotide dissociation stimulator
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS5 regulator of G-protein signaling 5
RHOBTB3 Rho-related BTB domain containing 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPRD1A regulation of nuclear pre-mRNA domain containing 1A
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A14 S100 calcium binding protein A14
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC4 syndecan 4
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SFN stratifin
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SORD sorbitol dehydrogenase
SOX9 SRY (sex determining region Y)-box 9
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STC1 stanniocalcin 1
STK38L serine/threonine kinase 38 like
STON1 stonin 1
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN transgelin
TBC1D31 TBC1 domain family, member 31
TCEAL4 transcription elongation factor A (SII)-like 4
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
THBS2 thrombospondin 2
TM7SF2 transmembrane 7 superfamily member 2
TNNC1 troponin C type 1 (slow)
TOX3 TOX high mobility group box family member 3
TP53 tumor protein p53
TPM2 tropomyosin 2 (beta)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TSPYL5 TSPY-like 5
TST thiosulfate sulfurtransferase (rhodanese)
USP11 ubiquitin specific peptidase 11
VCAN versican
WBP5 WW domain binding protein 5
WDR45 WD repeat domain 45
WDTC1 WD and tetratricopeptide repeats 1
WNT5A wingless-type MMTV integration site family, member 5A
XYLT1 xylosyltransferase I
ZBTB18 zinc finger and BTB domain containing 18
ZDHHC11 zinc finger, DHHC-type containing 11
ZFPM2 zinc finger protein, FOG family member 2
ZNF532 zinc finger protein 532

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADRM1 adhesion regulating molecule 1
AK4 adenylate kinase 4
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AMD1 adenosylmethionine decarboxylase 1
AMIGO2 adhesion molecule with Ig-like domain 2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AQP3 aquaporin 3 (Gill blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BST2 bone marrow stromal cell antigen 2
C7 complement component 7
CA2 carbonic anhydrase II
CAPN6 calpain 6
CCDC86 coiled-coil domain containing 86
CCR2 chemokine (C-C motif) receptor 2
CD320 CD320 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLU clusterin
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
CRELD2 cysteine-rich with EGF-like domains 2
CSTA cystatin A (stefin A)
CTSZ cathepsin Z
CXCL5 chemokine (C-X-C motif) ligand 5
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP3 dual specificity phosphatase 3
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
EPHA3 EPH receptor A3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM46C family with sequence similarity 46, member C
FSCN1 fascin actin-bundling protein 1
GCLM glutamate-cysteine ligase, modifier subunit
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLDC glycine dehydrogenase (decarboxylating)
GPI glucose-6-phosphate isomerase
GPM6B glycoprotein M6B
GPRC5C G protein-coupled receptor, class C, group 5, member C
GTPBP8 GTP-binding protein 8 (putative)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IFITM2 interferon induced transmembrane protein 2
IFRD2 interferon-related developmental regulator 2
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGLJ3 immunoglobulin lambda joining 3
KCTD12 potassium channel tetramerization domain containing 12
KRT17 keratin 17, type I
KRT5 keratin 5, type II
LEF1 lymphoid enhancer-binding factor 1
LOXL2 lysyl oxidase-like 2
LTF lactotransferrin
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMB microseminoprotein, beta-
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1M metallothionein 1M
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NFE2 nuclear factor, erythroid 2
NIT1 nitrilase 1
NKX3-1 NK3 homeobox 1
PDZK1 PDZ domain containing 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLK2 polo-like kinase 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PODXL podocalyxin-like
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PROCR protein C receptor, endothelial
PTBP3 polypyrimidine tract binding protein 3
PXDN peroxidasin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REXO2 RNA exonuclease 2
RGS13 regulator of G-protein signaling 13
RGS2 regulator of G-protein signaling 2
RNF114 ring finger protein 114
RPA1 replication protein A1, 70kDa
RPS11 ribosomal protein S11
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLA Src-like-adaptor
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC35F2 solute carrier family 35, member F2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC43A3 solute carrier family 43, member 3
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SPON1 spondin 1, extracellular matrix protein
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SQSTM1 sequestosome 1
SRM spermidine synthase
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
STMN2 stathmin 2
TACC1 transforming, acidic coiled-coil containing protein 1
TCL1A T-cell leukemia/lymphoma 1A
TCTN1 tectonic family member 1
TFRC transferrin receptor
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UGCG UDP-glucose ceramide glucosyltransferase
VDAC1 voltage-dependent anion channel 1