BRD-K02708799_GSK-1059615_A375_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

178 genes differentially expressed following the BRD-K02708799_GSK-1059615_A375_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AHNAK2 AHNAK nucleoprotein 2
ALDOA aldolase A, fructose-bisphosphate
ASS1 argininosuccinate synthase 1
BDKRB2 bradykinin receptor B2
BEX1 brain expressed, X-linked 1
C9ORF16 chromosome 9 open reading frame 16
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CALCOCO1 calcium binding and coiled-coil domain 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD59 CD59 molecule, complement regulatory protein
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN2 chimerin 2
CLCA2 chloride channel accessory 2
CLIC3 chloride intracellular channel 3
CRABP2 cellular retinoic acid binding protein 2
CRELD2 cysteine-rich with EGF-like domains 2
CXCL14 chemokine (C-X-C motif) ligand 14
DCN decorin
DHCR24 24-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FBLN1 fibulin 1
FGG fibrinogen gamma chain
FXYD3 FXYD domain containing ion transport regulator 3
G0S2 G0/G1 switch 2
GBP2 guanylate binding protein 2, interferon-inducible
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GREM1 gremlin 1, DAN family BMP antagonist
GSTA4 glutathione S-transferase alpha 4
GSTT1 glutathione S-transferase theta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFRD2 interferon-related developmental regulator 2
IGFBP5 insulin-like growth factor binding protein 5
LDLR low density lipoprotein receptor
LDOC1 leucine zipper, down-regulated in cancer 1
LTBP1 latent transforming growth factor beta binding protein 1
LYPD1 LY6/PLAUR domain containing 1
MAPK13 mitogen-activated protein kinase 13
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MCTP1 multiple C2 domains, transmembrane 1
MDK midkine (neurite growth-promoting factor 2)
METTL7A methyltransferase like 7A
MXRA5 matrix-remodelling associated 5
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEB nebulin
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NPEPL1 aminopeptidase-like 1
NREP neuronal regeneration related protein
NT5E 5'-nucleotidase, ecto (CD73)
PBX1 pre-B-cell leukemia homeobox 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PERP PERP, TP53 apoptosis effector
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPL periplakin
PRAF2 PRA1 domain family, member 2
PRKCI protein kinase C, iota
RND3 Rho family GTPase 3
SCGB2A1 secretoglobin, family 2A, member 1
SELENBP1 selenium binding protein 1
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SEPP1 selenoprotein P, plasma, 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SFN stratifin
SLC35E2B solute carrier family 35, member E2B
SMAD3 SMAD family member 3
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SPINK5 serine peptidase inhibitor, Kazal type 5
SSBP2 single-stranded DNA binding protein 2
SSPN sarcospan
STON1 stonin 1
SULF1 sulfatase 1
SYNM synemin, intermediate filament protein
TCEAL4 transcription elongation factor A (SII)-like 4
TCTN1 tectonic family member 1
TMEM45A transmembrane protein 45A
TMOD1 tropomodulin 1
TPBG trophoblast glycoprotein
TPM2 tropomyosin 2 (beta)
TRIM2 tripartite motif containing 2
TST thiosulfate sulfurtransferase (rhodanese)
TTC3 tetratricopeptide repeat domain 3
WNT5A wingless-type MMTV integration site family, member 5A
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACTN1 actinin, alpha 1
AK4 adenylate kinase 4
ANXA3 annexin A3
AQP3 aquaporin 3 (Gill blood group)
BNC2 basonuclin 2
C1QBP complement component 1, q subcomponent binding protein
C7 complement component 7
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CLU clusterin
COG7 component of oligomeric golgi complex 7
CSTA cystatin A (stefin A)
CTSZ cathepsin Z
DDIT4 DNA-damage-inducible transcript 4
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DLK1 delta-like 1 homolog (Drosophila)
DMTF1 cyclin D binding myb-like transcription factor 1
EDNRB endothelin receptor type B
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPHA3 EPH receptor A3
EZR ezrin
FABP6 fatty acid binding protein 6, ileal
FGF9 fibroblast growth factor 9
FOLR1 folate receptor 1 (adult)
FXYD6 FXYD domain containing ion transport regulator 6
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GATAD2A GATA zinc finger domain containing 2A
GDF15 growth differentiation factor 15
GRWD1 glutamate-rich WD repeat containing 1
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB8 heat shock 22kDa protein 8
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
KCTD12 potassium channel tetramerization domain containing 12
KRT81 keratin 81, type II
LRRC59 leucine rich repeat containing 59
LTF lactotransferrin
LYZ lysozyme
MARCKS myristoylated alanine-rich protein kinase C substrate
MATN2 matrilin 2
MCAM melanoma cell adhesion molecule
MMP9 matrix metallopeptidase 9
MOK MOK protein kinase
MSH6 mutS homolog 6
NEFL neurofilament, light polypeptide
NID2 nidogen 2 (osteonidogen)
NR2F1 nuclear receptor subfamily 2, group F, member 1
OGN osteoglycin
OSBPL10 oxysterol binding protein-like 10
P3H2 prolyl 3-hydroxylase 2
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PLK2 polo-like kinase 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
PUF60 poly-U binding splicing factor 60KDa
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS13 regulator of G-protein signaling 13
RGS2 regulator of G-protein signaling 2
RNH1 ribonuclease/angiogenin inhibitor 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A10 S100 calcium binding protein A10
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SERINC5 serine incorporator 5
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
TARS threonyl-tRNA synthetase
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TCL1A T-cell leukemia/lymphoma 1A
TMEM100 transmembrane protein 100
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNPO1 transportin 1
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
VCAM1 vascular cell adhesion molecule 1
VLDLR very low density lipoprotein receptor
WT1 Wilms tumor 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36L1 ZFP36 ring finger protein-like 1