BRD-K02641134_2-(4-(tert-butyl)benzamido)-4-chlorobenzoic acid KUC105998N_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

168 genes differentially expressed following the BRD-K02641134_2-(4-(tert-butyl)benzamido)-4-chlorobenzoic acid KUC105998N_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACP5 acid phosphatase 5, tartrate resistant
ARG2 arginase 2
CALR calreticulin
CCL4 chemokine (C-C motif) ligand 4
CCR2 chemokine (C-C motif) receptor 2
CD14 CD14 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLEC2B C-type lectin domain family 2, member B
CLEC3B C-type lectin domain family 3, member B
COL1A2 collagen, type I, alpha 2
CRISP3 cysteine-rich secretory protein 3
CST6 cystatin E/M
CX3CR1 chemokine (C-X3-C motif) receptor 1
DENND2D DENN/MADD domain containing 2D
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
F13A1 coagulation factor XIII, A1 polypeptide
FCGBP Fc fragment of IgG binding protein
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FGG fibrinogen gamma chain
FGL2 fibrinogen-like 2
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
HCAR3 hydroxycarboxylic acid receptor 3
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HOMER3 homer scaffolding protein 3
HP haptoglobin
HYOU1 hypoxia up-regulated 1
IGFBP5 insulin-like growth factor binding protein 5
KRT19 keratin 19, type I
LAPTM5 lysosomal protein transmembrane 5
LPAR6 lysophosphatidic acid receptor 6
LY6H lymphocyte antigen 6 complex, locus H
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MGP matrix Gla protein
MNDA myeloid cell nuclear differentiation antigen
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NPY1R neuropeptide Y receptor Y1
NRGN neurogranin (protein kinase C substrate, RC3)
OBSL1 obscurin-like 1
PDLIM3 PDZ and LIM domain 3
PEG3 paternally expressed 3
PFDN5 prefoldin subunit 5
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PRUNE2 prune homolog 2 (Drosophila)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PYCARD PYD and CARD domain containing
RGCC regulator of cell cycle
RNASE6 ribonuclease, RNase A family, k6
RPL10 ribosomal protein L10
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae)
TACSTD2 tumor-associated calcium signal transducer 2
TF transferrin
TTN titin
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD2 abhydrolase domain containing 2
AKAP7 A kinase (PRKA) anchor protein 7
ATF5 activating transcription factor 5
BASP1 brain abundant, membrane attached signal protein 1
BICC1 BicC family RNA binding protein 1
BRCA1 breast cancer 1, early onset
BST2 bone marrow stromal cell antigen 2
CA12 carbonic anhydrase XII
CCND3 cyclin D3
CDK4 cyclin-dependent kinase 4
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTGF connective tissue growth factor
CXCL13 chemokine (C-X-C motif) ligand 13
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCK deoxycytidine kinase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DLC1 DLC1 Rho GTPase activating protein
DPYSL2 dihydropyrimidinase-like 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FOLR1 folate receptor 1 (adult)
FSCN1 fascin actin-bundling protein 1
FSD1 fibronectin type III and SPRY domain containing 1
GLS glutaminase
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HOXB7 homeobox B7
HOXC6 homeobox C6
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IRS1 insulin receptor substrate 1
KIAA0368 KIAA0368
KIAA1033 KIAA1033
KIF14 kinesin family member 14
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KPNB1 karyopherin (importin) beta 1
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KYNU kynureninase
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LRRC16A leucine rich repeat containing 16A
LYPLA1 lysophospholipase I
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MET MET proto-oncogene, receptor tyrosine kinase
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MFSD10 major facilitator superfamily domain containing 10
MPZL1 myelin protein zero-like 1
MRPL19 mitochondrial ribosomal protein L19
MSH6 mutS homolog 6
MT1M metallothionein 1M
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEFH neurofilament, heavy polypeptide
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NKTR natural killer cell triggering receptor
NUP62 nucleoporin 62kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PBK PDZ binding kinase
PDGFC platelet derived growth factor C
PEG10 paternally expressed 10
PHF20 PHD finger protein 20
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PLS1 plastin 1
PPARG peroxisome proliferator-activated receptor gamma
PRPF4 pre-mRNA processing factor 4
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RAB14 RAB14, member RAS oncogene family
RAB9A RAB9A, member RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RCAN1 regulator of calcineurin 1
RSAD2 radical S-adenosyl methionine domain containing 2
SF1 splicing factor 1
SFN stratifin
SKP1 S-phase kinase-associated protein 1
SLC25A46 solute carrier family 25, member 46
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC35E3 solute carrier family 35, member E3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD2 SMAD family member 2
SMS spermine synthase
SPEN spen family transcriptional repressor
SPIN1 spindlin 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBB2B tubulin, beta 2B class IIb
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGCG UDP-glucose ceramide glucosyltransferase
USP1 ubiquitin specific peptidase 1
WSB2 WD repeat and SOCS box containing 2
ZBTB38 zinc finger and BTB domain containing 38