BRD-K02216544_3-cyclohexyl-6-[4-(2,3-dichlorophenyl)piperazin-1-yl]pyrimidine-2,4(1H,3H)-dione_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

38 genes differentially expressed following the BRD-K02216544_3-cyclohexyl-6-[4-(2,3-dichlorophenyl)piperazin-1-yl]pyrimidine-2,4(1H,3H)-dione_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CETN2 centrin, EF-hand protein, 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR7 7-dehydrocholesterol reductase
FABP7 fatty acid binding protein 7, brain
FADS1 fatty acid desaturase 1
GRWD1 glutamate-rich WD repeat containing 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
MSMO1 methylsterol monooxygenase 1
NCK1 NCK adaptor protein 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
RGS2 regulator of G-protein signaling 2
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SQLE squalene epoxidase
SSFA2 sperm specific antigen 2

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ANKRD10 ankyrin repeat domain 10
BRCA1 breast cancer 1, early onset
CFB complement factor B
CTSZ cathepsin Z
LAMA3 laminin, alpha 3
MCTP1 multiple C2 domains, transmembrane 1
NRIP1 nuclear receptor interacting protein 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SPINK1 serine peptidase inhibitor, Kazal type 1
TMEM5 transmembrane protein 5
TP53I3 tumor protein p53 inducible protein 3
ZBTB38 zinc finger and BTB domain containing 38