BRD-K02216544_3-cyclohexyl-6-[4-(2,3-dichlorophenyl)piperazin-1-yl]pyrimidine-2,4(1H,3H)-dione_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

54 genes differentially expressed following the BRD-K02216544_3-cyclohexyl-6-[4-(2,3-dichlorophenyl)piperazin-1-yl]pyrimidine-2,4(1H,3H)-dione_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ACSL3 acyl-CoA synthetase long-chain family member 3
CCNB2 cyclin B2
CENPU centromere protein U
CLDN3 claudin 3
COL5A2 collagen, type V, alpha 2
COL9A3 collagen, type IX, alpha 3
COMP cartilage oligomeric matrix protein
CSRP1 cysteine and glycine-rich protein 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DLD dihydrolipoamide dehydrogenase
ENC1 ectodermal-neural cortex 1 (with BTB domain)
HOXC10 homeobox C10
IDI1 isopentenyl-diphosphate delta isomerase 1
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
KIAA0101 KIAA0101
KIAA0355 KIAA0355
LTF lactotransferrin
NFIB nuclear factor I/B
PDE4B phosphodiesterase 4B, cAMP-specific
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SC5D sterol-C5-desaturase
SOX4 SRY (sex determining region Y)-box 4
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TTC3 tetratricopeptide repeat domain 3
VTCN1 V-set domain containing T cell activation inhibitor 1
ZEB1 zinc finger E-box binding homeobox 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AQP3 aquaporin 3 (Gill blood group)
DLK1 delta-like 1 homolog (Drosophila)
EIF5 eukaryotic translation initiation factor 5
FGG fibrinogen gamma chain
GSTA1 glutathione S-transferase alpha 1
IFI27 interferon, alpha-inducible protein 27
KCNK3 potassium channel, two pore domain subfamily K, member 3
KRT13 keratin 13, type I
KRT6A keratin 6A, type II
LAMA3 laminin, alpha 3
LUM lumican
LY6D lymphocyte antigen 6 complex, locus D
NTS neurotensin
PARP1 poly (ADP-ribose) polymerase 1
PDZK1IP1 PDZK1 interacting protein 1
PPL periplakin
RHCG Rh family, C glycoprotein
RRAD Ras-related associated with diabetes
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
STAR steroidogenic acute regulatory protein
TMEM5 transmembrane protein 5
ZDHHC11 zinc finger, DHHC-type containing 11