BRD-K02216544_3-cyclohexyl-6-[4-(2,3-dichlorophenyl)piperazin-1-yl]pyrimidine-2,4(1H,3H)-dione_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

176 genes differentially expressed following the BRD-K02216544_3-cyclohexyl-6-[4-(2,3-dichlorophenyl)piperazin-1-yl]pyrimidine-2,4(1H,3H)-dione_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ALDOC aldolase C, fructose-bisphosphate
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA1 carbonic anhydrase I
CALML5 calmodulin-like 5
CCDC92 coiled-coil domain containing 92
CCL20 chemokine (C-C motif) ligand 20
CCNI cyclin I
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CSRP1 cysteine and glycine-rich protein 1
CST3 cystatin C
CTSB cathepsin B
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDHD2 DDHD domain containing 2
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
EIF1 eukaryotic translation initiation factor 1
EMP1 epithelial membrane protein 1
EMP3 epithelial membrane protein 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FERMT2 fermitin family member 2
FOXJ3 forkhead box J3
GADD45A growth arrest and DNA-damage-inducible, alpha
GLIPR1 GLI pathogenesis-related 1
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
GRB10 growth factor receptor-bound protein 10
H3F3B H3 histone, family 3B (H3.3B)
HIST2H2BE histone cluster 2, H2be
HK1 hexokinase 1
HMOX1 heme oxygenase 1
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IL1RN interleukin 1 receptor antagonist
IL6R interleukin 6 receptor
IL7R interleukin 7 receptor
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KRT23 keratin 23, type I
KRT6B keratin 6B, type II
LAPTM5 lysosomal protein transmembrane 5
LITAF lipopolysaccharide-induced TNF factor
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LYZ lysozyme
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP1B microtubule-associated protein 1B
MCL1 myeloid cell leukemia 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MSX1 msh homeobox 1
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDRG1 N-myc downstream regulated 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDGFA platelet-derived growth factor alpha polypeptide
PDIA3 protein disulfide isomerase family A, member 3
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PI3 peptidase inhibitor 3, skin-derived
PKP1 plakophilin 1
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PMEPA1 prostate transmembrane protein, androgen induced 1
PPARD peroxisome proliferator-activated receptor delta
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RTN4 reticulon 4
S100A4 S100 calcium binding protein A4
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERTAD2 SERTA domain containing 2
SFN stratifin
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPARCL1 SPARC-like 1 (hevin)
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR3 small proline-rich protein 3
STOM stomatin
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
AK1 adenylate kinase 1
AMDHD2 amidohydrolase domain containing 2
ARFIP2 ADP-ribosylation factor interacting protein 2
ARMCX2 armadillo repeat containing, X-linked 2
BHLHE41 basic helix-loop-helix family, member e41
BICC1 BicC family RNA binding protein 1
C1S complement component 1, s subcomponent
CBR1 carbonyl reductase 1
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP4A charged multivesicular body protein 4A
CXCL12 chemokine (C-X-C motif) ligand 12
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPYD dihydropyrimidine dehydrogenase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ETFB electron-transfer-flavoprotein, beta polypeptide
FBN1 fibrillin 1
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FZD6 frizzled class receptor 6
GALE UDP-galactose-4-epimerase
HACD1 3-hydroxyacyl-CoA dehydratase 1
HEG1 heart development protein with EGF-like domains 1
HNMT histamine N-methyltransferase
IFRD2 interferon-related developmental regulator 2
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KIAA1033 KIAA1033
LAMA3 laminin, alpha 3
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUM lumican
LY96 lymphocyte antigen 96
MRPL12 mitochondrial ribosomal protein L12
MRPS16 mitochondrial ribosomal protein S16
MRPS33 mitochondrial ribosomal protein S33
MRPS7 mitochondrial ribosomal protein S7
MSRB1 methionine sulfoxide reductase B1
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
NID2 nidogen 2 (osteonidogen)
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NUP37 nucleoporin 37kDa
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
OXA1L oxidase (cytochrome c) assembly 1-like
PFKM phosphofructokinase, muscle
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PPARG peroxisome proliferator-activated receptor gamma
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRDX2 peroxiredoxin 2
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RWDD2B RWD domain containing 2B
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SPATA20 spermatogenesis associated 20
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SVIL supervillin
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TCTA T-cell leukemia translocation altered
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
THTPA thiamine triphosphatase
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TMEM5 transmembrane protein 5
TRIP6 thyroid hormone receptor interactor 6
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UQCRB ubiquinol-cytochrome c reductase binding protein
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa
ZNF302 zinc finger protein 302
ZWINT ZW10 interacting kinetochore protein