BRD-K02216544_3-cyclohexyl-6-[4-(2,3-dichlorophenyl)piperazin-1-yl]pyrimidine-2,4(1H,3H)-dione_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-K02216544_3-cyclohexyl-6-[4-(2,3-dichlorophenyl)piperazin-1-yl]pyrimidine-2,4(1H,3H)-dione_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCL2A1 BCL2-related protein A1
C1ORF54 chromosome 1 open reading frame 54
CCK cholecystokinin
CD24 CD24 molecule
CD46 CD46 molecule, complement regulatory protein
CD59 CD59 molecule, complement regulatory protein
CENPN centromere protein N
CETN2 centrin, EF-hand protein, 2
CKB creatine kinase, brain
CLDN5 claudin 5
CMC2 C-x(9)-C motif containing 2
CXCL14 chemokine (C-X-C motif) ligand 14
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDA1 DET1 and DDB1 associated 1
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZR ezrin
FAM129A family with sequence similarity 129, member A
FASTKD5 FAST kinase domains 5
FBXO11 F-box protein 11
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GSN gelsolin
GUK1 guanylate kinase 1
HDAC9 histone deacetylase 9
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA13 heat shock protein 70kDa family, member 13
IDI1 isopentenyl-diphosphate delta isomerase 1
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KCTD12 potassium channel tetramerization domain containing 12
KLF10 Kruppel-like factor 10
KLHL7 kelch-like family member 7
KRT6B keratin 6B, type II
LCN2 lipocalin 2
LEPROT leptin receptor overlapping transcript
LPAR6 lysophosphatidic acid receptor 6
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MKRN1 makorin ring finger protein 1
MLF1 myeloid leukemia factor 1
NUP98 nucleoporin 98kDa
OLFM4 olfactomedin 4
PAPOLA poly(A) polymerase alpha
PCIF1 PDX1 C-terminal inhibiting factor 1
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PRR7 proline rich 7 (synaptic)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
S100A8 S100 calcium binding protein A8
SDC2 syndecan 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLIT2 slit homolog 2 (Drosophila)
SPARCL1 SPARC-like 1 (hevin)
TBXA2R thromboxane A2 receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP3 TIMP metallopeptidase inhibitor 3
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase
XIST X inactive specific transcript (non-protein coding)
ZNF589 zinc finger protein 589
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ADM adrenomedullin
AK2 adenylate kinase 2
ANKRD10 ankyrin repeat domain 10
ANKRD17 ankyrin repeat domain 17
ANKRD28 ankyrin repeat domain 28
ANKRD36B ankyrin repeat domain 36B
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
AQP3 aquaporin 3 (Gill blood group)
ATXN1 ataxin 1
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BRCA1 breast cancer 1, early onset
C2CD2 C2 calcium-dependent domain containing 2
CA2 carbonic anhydrase II
CCNF cyclin F
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEMIP cell migration inducing protein, hyaluronan binding
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DHRS2 dehydrogenase/reductase (SDR family) member 2
DPYSL3 dihydropyrimidinase-like 3
DST dystonin
ELANE elastase, neutrophil expressed
FAM208A family with sequence similarity 208, member A
FAM57A family with sequence similarity 57, member A
FNDC3B fibronectin type III domain containing 3B
FOLR1 folate receptor 1 (adult)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLS glutaminase
GSAP gamma-secretase activating protein
HOXC6 homeobox C6
IGHD immunoglobulin heavy constant delta
IGL immunoglobulin lambda locus
IRS2 insulin receptor substrate 2
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KRT7 keratin 7, type II
LARP4 La ribonucleoprotein domain family, member 4
LGALS8 lectin, galactoside-binding, soluble, 8
LOC100505650 uncharacterized LOC100505650
LYST lysosomal trafficking regulator
MACF1 microtubule-actin crosslinking factor 1
MALT1 MALT1 paracaspase
MBNL2 muscleblind-like splicing regulator 2
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MTDH metadherin
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
N4BP2L2 NEDD4 binding protein 2-like 2
NMT1 N-myristoyltransferase 1
NT5E 5'-nucleotidase, ecto (CD73)
NUP62 nucleoporin 62kDa
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE10A phosphodiesterase 10A
PDE4B phosphodiesterase 4B, cAMP-specific
PDS5A PDS5 cohesin associated factor A
PLA2G16 phospholipase A2, group XVI
PLAC8 placenta-specific 8
PLEKHA5 pleckstrin homology domain containing, family A member 5
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRKCA protein kinase C, alpha
PXDN peroxidasin
RAB31 RAB31, member RAS oncogene family
RPL31 ribosomal protein L31
RUNX1 runt-related transcription factor 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SPG11 spastic paraplegia 11 (autosomal recessive)
SRSF6 serine/arginine-rich splicing factor 6
STAR steroidogenic acute regulatory protein
TCERG1 transcription elongation regulator 1
TCF4 transcription factor 4
TFPI2 tissue factor pathway inhibitor 2
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM2 transmembrane protein 2
TMEM5 transmembrane protein 5
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAK2 trafficking protein, kinesin binding 2
UBE3C ubiquitin protein ligase E3C
VCAN versican
ZMYM4 zinc finger, MYM-type 4
ZNF451 zinc finger protein 451