BRD-K02113016_AZD2281 (KU59436)_SW620_6.0_h_44.4_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

111 genes differentially expressed following the BRD-K02113016_AZD2281 (KU59436)_SW620_6.0_h_44.4_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ADORA2B adenosine A2b receptor
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD24 CD24 molecule
CD52 CD52 molecule
CD9 CD9 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLCA4 chloride channel accessory 4
CSTA cystatin A (stefin A)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
DNM1L dynamin 1-like
DSP desmoplakin
DST dystonin
DUOX2 dual oxidase 2
ECM1 extracellular matrix protein 1
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FADS3 fatty acid desaturase 3
FGFBP1 fibroblast growth factor binding protein 1
FOSL1 FOS-like antigen 1
FST follistatin
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GJA1 gap junction protein, alpha 1, 43kDa
GREM1 gremlin 1, DAN family BMP antagonist
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IER3 immediate early response 3
INHBA inhibin, beta A
IPO13 importin 13
IRF6 interferon regulatory factor 6
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMB3 laminin, beta 3
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP10 matrix metallopeptidase 10
MYBPC1 myosin binding protein C, slow type
NARFL nuclear prelamin A recognition factor-like
NDRG1 N-myc downstream regulated 1
OLFM4 olfactomedin 4
PEA15 phosphoprotein enriched in astrocytes 15
PHLDA1 pleckstrin homology-like domain, family A, member 1
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PPARG peroxisome proliferator-activated receptor gamma
S100A13 S100 calcium binding protein A13
S100A14 S100 calcium binding protein A14
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
TBX3 T-box 3
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGIF1 TGFB-induced factor homeobox 1
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TSPAN1 tetraspanin 1
UBE3C ubiquitin protein ligase E3C
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
AGR2 anterior gradient 2
AKAP8 A kinase (PRKA) anchor protein 8
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AURKA aurora kinase A
CDC42 cell division cycle 42
CST3 cystatin C
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
GPM6A glycoprotein M6A
HIST1H2BG histone cluster 1, H2bg
ICAM2 intercellular adhesion molecule 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IRX5 iroquois homeobox 5
KAZN kazrin, periplakin interacting protein
KIF14 kinesin family member 14
LAMP5 lysosomal-associated membrane protein family, member 5
LOC100505650 uncharacterized LOC100505650
NOTCH2 notch 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
PLK1 polo-like kinase 1
SDPR serum deprivation response
SST somatostatin
THAP11 THAP domain containing 11
TPPP3 tubulin polymerization-promoting protein family member 3
VWF von Willebrand factor