BRD-K01976263_Emetine Dihydrochloride Hydrate (74)_SW620_6.0_h_0.63_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

78 genes differentially expressed following the BRD-K01976263_Emetine Dihydrochloride Hydrate (74)_SW620_6.0_h_0.63_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CEP57 centrosomal protein 57kDa
CHEK1 checkpoint kinase 1
CLU clusterin
CPB1 carboxypeptidase B1 (tissue)
CTH cystathionine gamma-lyase
CXCL5 chemokine (C-X-C motif) ligand 5
CYCS cytochrome c, somatic
DEPTOR DEP domain containing MTOR-interacting protein
ENC1 ectodermal-neural cortex 1 (with BTB domain)
G0S2 G0/G1 switch 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GBP1 guanylate binding protein 1, interferon-inducible
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
KLF5 Kruppel-like factor 5 (intestinal)
MAP7 microtubule-associated protein 7
MKNK1 MAP kinase interacting serine/threonine kinase 1
MRPS30 mitochondrial ribosomal protein S30
NKX3-1 NK3 homeobox 1
NLRP2 NLR family, pyrin domain containing 2
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPA1 pyrophosphatase (inorganic) 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SRSF6 serine/arginine-rich splicing factor 6
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TPD52 tumor protein D52
TRIB1 tribbles pseudokinase 1
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
AKR1C2 aldo-keto reductase family 1, member C2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CD36 CD36 molecule (thrombospondin receptor)
CD93 CD93 molecule
CDH5 cadherin 5, type 2 (vascular endothelium)
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CTGF connective tissue growth factor
CXCL14 chemokine (C-X-C motif) ligand 14
DLC1 DLC1 Rho GTPase activating protein
EMP2 epithelial membrane protein 2
FABP4 fatty acid binding protein 4, adipocyte
FKBP1B FK506 binding protein 1B, 12.6 kDa
FZD10 frizzled class receptor 10
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GNAS GNAS complex locus
HSPA1A heat shock 70kDa protein 1A
LAPTM5 lysosomal protein transmembrane 5
LMO2 LIM domain only 2 (rhombotin-like 1)
LPAR6 lysophosphatidic acid receptor 6
LYZ lysozyme
MARCKSL1 MARCKS-like 1
MFAP5 microfibrillar associated protein 5
MGP matrix Gla protein
NEFL neurofilament, light polypeptide
NFIB nuclear factor I/B
PALMD palmdelphin
PDIA3 protein disulfide isomerase family A, member 3
PEG10 paternally expressed 10
PGAP3 post-GPI attachment to proteins 3
PLIN2 perilipin 2
PLXDC1 plexin domain containing 1
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
TRD T cell receptor delta locus
TRIL TLR4 interactor with leucine-rich repeats
TYROBP TYRO protein tyrosine kinase binding protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)