BRD-K01896723_2-morpholino-N-((5-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-K01896723_2-morpholino-N-((5-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
C7 complement component 7
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CHGB chromogranin B
CLIC5 chloride intracellular channel 5
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CSTA cystatin A (stefin A)
CTTN cortactin
CXCL2 chemokine (C-X-C motif) ligand 2
DHCR24 24-dehydrocholesterol reductase
EIF5A eukaryotic translation initiation factor 5A
FGG fibrinogen gamma chain
GPX3 glutathione peroxidase 3
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
LTF lactotransferrin
MMP9 matrix metallopeptidase 9
NTS neurotensin
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
PLCL1 phospholipase C-like 1
POSTN periostin, osteoblast specific factor
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
SCG2 secretogranin II
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC2 syndecan 2
SELENBP1 selenium binding protein 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TIMP3 TIMP metallopeptidase inhibitor 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM2 tropomyosin 2 (beta)
TUSC3 tumor suppressor candidate 3

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
BAG3 BCL2-associated athanogene 3
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CDCA4 cell division cycle associated 4
CHERP calcium homeostasis endoplasmic reticulum protein
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DCLRE1C DNA cross-link repair 1C
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FASTKD5 FAST kinase domains 5
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GAREM GRB2 associated, regulator of MAPK1
GOSR1 golgi SNAP receptor complex member 1
H2AFX H2A histone family, member X
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXA1 homeobox A1
HOXA5 homeobox A5
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
KAT6B K(lysine) acetyltransferase 6B
KEAP1 kelch-like ECH-associated protein 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
NET1 neuroepithelial cell transforming 1
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PLIN2 perilipin 2
PLK1 polo-like kinase 1
RGS2 regulator of G-protein signaling 2
RLF rearranged L-myc fusion
RNMT RNA (guanine-7-) methyltransferase
SASH1 SAM and SH3 domain containing 1
SERTAD2 SERTA domain containing 2
SETD5 SET domain containing 5
SFRP1 secreted frizzled-related protein 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMAD3 SMAD family member 3
SMG8 SMG8 nonsense mediated mRNA decay factor
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBX3 T-box 3
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TICAM1 toll-like receptor adaptor molecule 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNPO1 transportin 1
TSC22D2 TSC22 domain family, member 2
WEE1 WEE1 G2 checkpoint kinase
ZCCHC8 zinc finger, CCHC domain containing 8