BRD-K01896723_2-morpholino-N-((5-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

174 genes differentially expressed following the BRD-K01896723_2-morpholino-N-((5-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIDA axin interactor, dorsalization associated
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AQP9 aquaporin 9
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
CA4 carbonic anhydrase IV
CADM1 cell adhesion molecule 1
CBS cystathionine-beta-synthase
CCL20 chemokine (C-C motif) ligand 20
CKB creatine kinase, brain
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
CORO1A coronin, actin binding protein, 1A
CPE carboxypeptidase E
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
EGFL6 EGF-like-domain, multiple 6
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESR1 estrogen receptor 1
GAGE3 G antigen 3
GPM6B glycoprotein M6B
HIST1H1C histone cluster 1, H1c
HIST1H2BC histone cluster 1, H2bc
HIST1H3H histone cluster 1, H3h
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGN4 high mobility group nucleosomal binding domain 4
HMGN5 high mobility group nucleosome binding domain 5
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGL immunoglobulin lambda locus
ISG15 ISG15 ubiquitin-like modifier
JAG1 jagged 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT17 keratin 17, type I
LAMP3 lysosomal-associated membrane protein 3
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCUR1 mitochondrial calcium uniporter regulator 1
MFAP2 microfibrillar-associated protein 2
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NPEPL1 aminopeptidase-like 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PGK1 phosphoglycerate kinase 1
PLS3 plastin 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRAME preferentially expressed antigen in melanoma
PRSS21 protease, serine, 21 (testisin)
PSPH phosphoserine phosphatase
PTN pleiotrophin
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
S100A1 S100 calcium binding protein A1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFRP4 secreted frizzled-related protein 4
SMYD3 SET and MYND domain containing 3
STON1 stonin 1
SULF1 sulfatase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THY1 Thy-1 cell surface antigen
TUSC3 tumor suppressor candidate 3
WISP2 WNT1 inducible signaling pathway protein 2

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMD1 adenosylmethionine decarboxylase 1
ARPC5L actin related protein 2/3 complex, subunit 5-like
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BLCAP bladder cancer associated protein
C2CD2 C2 calcium-dependent domain containing 2
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CD164 CD164 molecule, sialomucin
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHERP calcium homeostasis endoplasmic reticulum protein
CLTC clathrin, heavy chain (Hc)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
ECD ecdysoneless homolog (Drosophila)
EIF4E eukaryotic translation initiation factor 4E
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCGBP Fc fragment of IgG binding protein
FOSL1 FOS-like antigen 1
GMDS GDP-mannose 4,6-dehydratase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP6 insulin-like growth factor binding protein 6
ITGA6 integrin, alpha 6
LDLR low density lipoprotein receptor
LIPG lipase, endothelial
LPIN1 lipin 1
LTF lactotransferrin
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARCKS myristoylated alanine-rich protein kinase C substrate
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MED6 mediator complex subunit 6
MELK maternal embryonic leucine zipper kinase
MKNK2 MAP kinase interacting serine/threonine kinase 2
MYBPC1 myosin binding protein C, slow type
NKX3-1 NK3 homeobox 1
NOP56 NOP56 ribonucleoprotein
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NSFL1C NSFL1 (p97) cofactor (p47)
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PLAU plasminogen activator, urokinase
PNP purine nucleoside phosphorylase
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PROM1 prominin 1
PSCA prostate stem cell antigen
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAE1 ribonucleic acid export 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNPS1 RNA binding protein S1, serine-rich domain
RPL27A ribosomal protein L27a
RPL36AL ribosomal protein L36a-like
RPS11 ribosomal protein S11
S100P S100 calcium binding protein P
SFRP1 secreted frizzled-related protein 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMC4 structural maintenance of chromosomes 4
SNRPB2 small nuclear ribonucleoprotein polypeptide B
SOX9 SRY (sex determining region Y)-box 9
SPTBN1 spectrin, beta, non-erythrocytic 1
SRPX sushi-repeat containing protein, X-linked
SRSF5 serine/arginine-rich splicing factor 5
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBC1D4 TBC1 domain family, member 4
TBL1X transducin (beta)-like 1X-linked
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNC tenascin C
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP1 topoisomerase (DNA) I
TPBG trophoblast glycoprotein
TSPAN8 tetraspanin 8
TWF2 twinfilin actin binding protein 2
TXLNA taxilin alpha
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
USP22 ubiquitin specific peptidase 22
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
WDR6 WD repeat domain 6
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon