BRD-K01896723_2-morpholino-N-((5-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

196 genes differentially expressed following the BRD-K01896723_2-morpholino-N-((5-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGA aspartylglucosaminidase
AIDA axin interactor, dorsalization associated
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA4 annexin A4
APLP1 amyloid beta (A4) precursor-like protein 1
AREG amphiregulin
CALD1 caldesmon 1
CD52 CD52 molecule
CLC Charcot-Leyden crystal galectin
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A1 collagen, type VI, alpha 1
CSTA cystatin A (stefin A)
CYBRD1 cytochrome b reductase 1
DCN decorin
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOK5 docking protein 5
DPYSL3 dihydropyrimidinase-like 3
ECM1 extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EREG epiregulin
FLRT2 fibronectin leucine rich transmembrane protein 2
FN1 fibronectin 1
FOXF1 forkhead box F1
GJA1 gap junction protein, alpha 1, 43kDa
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IER3 immediate early response 3
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
INA internexin neuronal intermediate filament protein, alpha
ISG15 ISG15 ubiquitin-like modifier
LCN2 lipocalin 2
LTB lymphotoxin beta (TNF superfamily, member 3)
MAOA monoamine oxidase A
MDFIC MyoD family inhibitor domain containing
MEIS2 Meis homeobox 2
MFSD10 major facilitator superfamily domain containing 10
MSN moesin
MX1 MX dynamin-like GTPase 1
NLRP2 NLR family, pyrin domain containing 2
NSG1 neuron specific gene family member 1
PBX3 pre-B-cell leukemia homeobox 3
PSPH phosphoserine phosphatase
QDPR quinoid dihydropteridine reductase
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG2 secretogranin II
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPON1 spondin 1, extracellular matrix protein
SRPX sushi-repeat containing protein, X-linked
TFPI2 tissue factor pathway inhibitor 2
THY1 Thy-1 cell surface antigen
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VIM vimentin
VTCN1 V-set domain containing T cell activation inhibitor 1
XAF1 XIAP associated factor 1
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACBD3 acyl-CoA binding domain containing 3
ADNP activity-dependent neuroprotector homeobox
ADNP2 ADNP homeobox 2
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AFF1 AF4/FMR2 family, member 1
AGO2 argonaute RISC catalytic component 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
ASF1A anti-silencing function 1A histone chaperone
ASXL2 additional sex combs like transcriptional regulator 2
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BLCAP bladder cancer associated protein
BRPF1 bromodomain and PHD finger containing, 1
CCDC86 coiled-coil domain containing 86
CCNA2 cyclin A2
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHD1 chromodomain helicase DNA binding protein 1
CHSY1 chondroitin sulfate synthase 1
COIL coilin
COL15A1 collagen, type XV, alpha 1
CREBBP CREB binding protein
CXCL9 chemokine (C-X-C motif) ligand 9
DBF4 DBF4 zinc finger
DCLRE1C DNA cross-link repair 1C
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EIF5 eukaryotic translation initiation factor 5
EPHA3 EPH receptor A3
ESR1 estrogen receptor 1
EXOSC4 exosome component 4
FAM208B family with sequence similarity 208, member B
FBXO11 F-box protein 11
FGF13 fibroblast growth factor 13
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GEMIN4 gem (nuclear organelle) associated protein 4
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HOXC6 homeobox C6
IER5 immediate early response 5
IGHM immunoglobulin heavy constant mu
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KIF14 kinesin family member 14
LSG1 large 60S subunit nuclear export GTPase 1
MCM10 minichromosome maintenance complex component 10
MED13 mediator complex subunit 13
MSH6 mutS homolog 6
MSL2 male-specific lethal 2 homolog (Drosophila)
MTMR4 myotubularin related protein 4
N4BP2L2 NEDD4 binding protein 2-like 2
NCK1 NCK adaptor protein 1
NCOA3 nuclear receptor coactivator 3
NET1 neuroepithelial cell transforming 1
NOL11 nucleolar protein 11
NOP2 NOP2 nucleolar protein
NOTCH2NL notch 2 N-terminal like
NRIP1 nuclear receptor interacting protein 1
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1
NUP153 nucleoporin 153kDa
NUP62 nucleoporin 62kDa
NXT1 nuclear transport factor 2-like export factor 1
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDGFA platelet-derived growth factor alpha polypeptide
PER2 period circadian clock 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
RAD9A RAD9 homolog A (S. pombe)
RAP2B RAP2B, member of RAS oncogene family
RBM15 RNA binding motif protein 15
RNMT RNA (guanine-7-) methyltransferase
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCAF8 SR-related CTD-associated factor 8
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMG8 SMG8 nonsense mediated mRNA decay factor
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TBP TATA box binding protein
TBX2 T-box 2
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGIF1 TGFB-induced factor homeobox 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLK2 tousled-like kinase 2
TOB2 transducer of ERBB2, 2
TRIM33 tripartite motif containing 33
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WAC WW domain containing adaptor with coiled-coil
WEE1 WEE1 G2 checkpoint kinase
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
ZC3H4 zinc finger CCCH-type containing 4
ZCCHC2 zinc finger, CCHC domain containing 2
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36L2 ZFP36 ring finger protein-like 2
ZMYM2 zinc finger, MYM-type 2
ZNF131 zinc finger protein 131